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Index > Protein center > SLC1A5(Gene name) > Human
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  • SLC1A5 (Gene name),
  • Neutral amino acid transporter B(0) (Protein name ),  AAAT_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    SLC1A5(ASCT2;M7V1;RDR;RDRC);
    Protein name:
    Neutral amino acid transporter B(0)(ATB(0));
    Alternative:
    RD114/simian type D retrovirus receptor;Baboon M7 virus receptor;Solute carrier family 1 member 5;Sodium-dependent neutral amino acid transporter type 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Has a broad substrate specificity, a preference for zwitterionic amino acids, and a sodium-dependence. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated amino acids, anionic amino acids, and cationic amino acids. Act as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses.
    Subcellular Location:
    Membrane Multi-pass membrane protein Melanosome Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
    Protein Attributes:
    Sequence length:
    541
    Sequence:
    50:
    MVADPPRDSK | GLAAAEPTAN | GGLALASIED | QGAAAGGYCG | SRDQVRRCLR | 
    100:
    ANLLVLLTVV | AVVAGVALGL | GVSGAGGALA | LGPERLSAFV | FPGELLLRLL | 
    150:
    RMIILPLVVC | SLIGGAASLD | PGALGRLGAW | ALLFFLVTTL | LASALGVGLA | 
    200:
    LALQPGAASA | AINASVGAAG | SAENAPSKEV | LDSFLDLARN | IFPSNLVSAA | 
    250:
    FRSYSTTYEE | RNITGTRVKV | PVGQEVEGMN | ILGLVVFAIV | FGVALRKLGP | 
    300:
    EGELLIRFFN | SFNEATMVLV | SWIMWYAPVG | IMFLVAGKIV | EMEDVGLLFA | 
    350:
    RLGKYILCCL | LGHAIHGLLV | LPLIYFLFTR | KNPYRFLWGI | VTPLATAFGT | 
    400:
    SSSSATLPLM | MKCVEENNGV | AKHISRFILP | IGATVNMDGA | ALFQCVAAVF | 
    450:
    IAQLSQQSLD | FVKIITILVT | ATASSVGAAG | IPAGGVLTLA | IILEAVNLPV | 
    500:
    DHISLILAVD | WLVDRSCTVL | NVEGDALGAG | LLQNYVDRTE | SRSTEPELIQ | 
    541:
    VKSELPLDPL | PVPTEEGNPL | LKHYRGPAGD | ATVASEKESV | M
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    SMR:
    Pfam:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human ATB(0)
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    ELISA Kit for Human ATB(0)
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    ELISA Kit for Human ATB(0)
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    CLIA Kit for Human ATB(0)
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    CLIA Kit for Human ATB(0)
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    CLIA Kit for Human ATB(0)
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    Packing:
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    Polyclonal Antibody for Human ATB(0)
    Polyclonal Antibody for Human ATB(0)
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    P10939Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human ATB(0)
    Polyclonal Antibody for Human ATB(0)
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    Packing:
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    Monoclonal Antibody for Human ATB(0)
    Monoclonal Antibody for Human ATB(0)
    Monoclonal Antibody for Human ATB(0)
    Monoclonal Antibody for Human ATB(0)
    Protein for Human ATB(0)
    Protein for Human ATB(0)
    Protein for Human ATB(0)
    Protein for Human ATB(0)

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    References
    1. 1.
      "Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line."
      Kekuda R. , Prasad P.D. , Fei Y.-J. , Torres-Zamorano V. , Sinha S. , Yang-Feng T.L. , Leibach F.H. , Ganapathy V.
      J. Biol. Chem.271:18657-18661(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Choriocarcinoma.
    2. 2.
      "The RD114/simian type D retrovirus receptor is a neutral amino acid transporter."
      Rasko J.E.J. , Battini J.L. , Gottschalk R.J. , Mazo I. , Miller A.D.
      Proc. Natl. Acad. Sci. U.S.A.96:2129-2134(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION AS A VIRAL RECEPTOR
    3. 3.
      "A sodium-dependent neutral-amino-acid transporter mediates infections of feline and baboon endogenous retroviruses and simian type D retroviruses."
      Tailor C.S. , Nouri A. , Zhao Y. , Takeuchi Y. , Kabat D.
      J. Virol.73:4470-4474(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION AS A VIRAL RECEPTOR
    4. 4.
      "Cloning of ASCT2 cDNA from MCF-7 cells and its expression in B16 cells."
      Ouyang D.-Y. , Xu L.-H. , He X.-H. , Zha Q.-B. , Guo H. , Gao Q. , Zhang Y.-T.
      Submitted (2009-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3);VARIANT LEU-512
      tissue: Esophagus.
      tissue: Thymus.
    6. 6.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Kidney.
    9. 9.
      "Truncated forms of the dual function human ASCT2 neutral amino acid transporter/retroviral receptor are translationally initiated at multiple alternative CUG and GUG codons."
      Tailor C.S. , Marin M. , Nouri A. , Kavanaugh M.P. , Kabat D.
      J. Biol. Chem.276:27221-27230(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-541 (ISOFORM 1);ALTERNATIVE INITIATION
    10. 10.
      "An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor."
      Blond J.-L. , Lavillette D. , Cheynet V. , Bouton O. , Oriol G. , Chapel-Fernandes S. , Mandrand B. , Mallet F. , Cosset F.-L.
      J. Virol.74:3321-3329(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    11. 11.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-535;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    12. 12.
      "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."
      Chi A. , Valencia J.C. , Hu Z.-Z. , Watabe H. , Yamaguchi H. , Mangini N.J. , Huang H. , Canfield V.A. , Cheng K.C. , Yang F. , Abe R. , Yamagishi S. , Shabanowitz J. , Hearing V.J. , Wu C. , Appella E. , Hunt D.F.
      J. Proteome Res.5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
      tissue: Melanoma.
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-535;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 14.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
      Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-212
      tissue: Leukemic T-cell.
    16. 16.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-503 AND SER-535;VARIANT [LARGE SCALE ANALYSIS] LEU-512;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    17. 17.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-535;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    19. 19.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-493;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    20. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    21. 21.
      "A novel human endogenous retroviral protein inhibits cell-cell fusion."
      Sugimoto J. , Sugimoto M. , Bernstein H. , Jinno Y. , Schust D.
      Sci. Rep.3:1462-1462(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ERVH48-1;SUBCELLULAR LOCATION
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