Protein name:
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) ;
Alternative:
Mammalian disintegrin-metalloprotease ;Kuzbanian protein homolog ;
CD:
CD156c ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function. Interacts with EPHA2.
Function:
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch. May regulate the EFNA5-EPHA3 signaling.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
GPELLRKKRT | TLPERNTCQL | YIQTDHLFFK | SYGTREAVIA | QISSHVKAID |
100:
AIYQTTDFSG | IRNISFMVKR | IRINTTSDEK | DPTNPFRFPN | IGVEKFLELN |
150:
SEQNHDDYCL | AYVFTDRDFD | DGVLGLAWVG | APSGSSGGIC | EKSKLYSDGK |
200:
KKSLNTGIIT | VQNYGSHVPP | KVSHITFAHE | VGHNFGSPHD | SGTECTPGES |
250:
KNLGQKENGN | YIMYARATSG | DKLNNNKFSL | CSIRNISQVL | EKKRNNCFVE |
300:
SGQPICGNGM | VEQGEECDCG | YSDQCKDECC | FDANQPEGKK | CKLKPGKQCS |
350:
PSQGPCCTAQ | CAFKSKSEKC | RDDSDCAKEG | ICNGFTALCP | ASDPKPNFTD |
400:
CNRHTQVCIN | GQCAGSICEK | YDLEECTCAS | SDGKDDKELC | HVCCMKKMAP |
450:
STCASTGSLQ | WNKQFTGRTI | TLQPGSPCND | FRGYCDVFMR | CRLVDADGPL |
500:
ARLKKAIFSP | QLYENIAEWI | VAHWWAVLLM | GIALIMLMAG | FIKICSVHTP |
544:
SSNPKLPPPK | PLPGTLKRRR | PPQPIQQPQR | QRPRESYQMG | HMRR
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Pig
Mouse
Bovine
Rat
ELISA Kit for Rat ADAM 10
ELISA Kit for Rat ADAM 10
ELISA Kit for Rat ADAM 10
ELISA Kit for Rat ADAM 10
ELISA Kit for Rat ADAM 10
Polyclonal Antibody for Rat ADAM 10
Polyclonal Antibody for Rat ADAM 10
Polyclonal Antibody for Rat ADAM 10
Polyclonal Antibody for Rat ADAM 10
Polyclonal Antibody for Rat ADAM 10
Monoclonal Antibody for Rat ADAM 10
Monoclonal Antibody for Rat ADAM 10
Monoclonal Antibody for Rat ADAM 10
Monoclonal Antibody for Rat ADAM 10
Monoclonal Antibody for Rat ADAM 10
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Sprague-Dawley .
tissue :
Brain .