Adam15 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comAdam15 ELISA Kit for Rat(Rattus norvegicus)

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Adam15 (Gene name),

Disintegrin and metalloproteinase domain-containing protein 15 (Protein name ), ADA15_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Adam15(Mdc15);

Protein name:

Disintegrin and metalloproteinase domain-containing protein 15(ADAM 15);

Alternative:

Metalloprotease RGD disintegrin protein;CRII-7;Metargidin;Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15(MDC-15);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with ITAGV-ITGB3 (vitronectin receptor), PACSIN3 and SNX9. PACSIN3 and SNX9 preferentially bind the precursor but not the processed form of ADAM15, suggesting that the interaction occurs in a secretory pathway compartment prior to the medial Golgi. Interacts with ITAG9-ITGB1. Interacts specifically with Src family protein-tyrosine kinases (PTKs). Interacts with SH3PXD2A. Interacts with ITAGV-ITGB1. Interacts with GRB2, HCK, ITSN1, ITSN2, LYN, MAPK1, MAPK3, NCF1, NCK1, nephrocystin, PTK6, SNX33, and SRC.

Function:

Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.

Subcellular Location:

Endomembrane system Single-pass type I membrane protein Cell junction adherens junction Cell projection cilium flagellum Cytoplasmic vesicle secretory vesicle acrosome The majority of the protein is localized in a perinuclear compartment which may correspond to the trans-Golgi network or the late endosome. The pro-protein is the major detectable form on the cell surface, whereas the majority of the protein in the cell is processed.

Protein Attributes:

Sequence length:

864

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864:

RPAPPPPAAS | SLYL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

rno:57025

Pfam:

PF08516

UniGene:

Rn.162607

String:

Q9QYV0

STRING:

10116.ENSRNOP00000039351

Uniprot:

Q9QYV0

FOR

ELISA Kit for Rat ADAM 15

CLIA Kit for Rat ADAM 15

Polyclonal Antibody for Rat ADAM 15

Monoclonal Antibody for Rat ADAM 15

Protein for Rat ADAM 15

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cellular localization of the disintegrin CRII-7/rMDC15 mRNA in rat PNS and CNS and regulated expression in postnatal development and after nerve injury."
Bosse F. , Petzold G. , Greiner-Petter R. , Pippirs U. , Gillen C. , Mueller H.-W.
Glia32:313-327(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Sciatic nerve.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Prostate.

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