ADAM17 ELISA Kit for Human(Homo sapiens) | EIAab.comADAM17 ELISA Kit for Human(Homo sapiens)

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ADAM17 (Gene name),

Disintegrin and metalloproteinase domain-containing protein 17 (Protein name ), ADA17_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

ADAM17(CSVP;TACE);

Protein name:

Disintegrin and metalloproteinase domain-containing protein 17(ADAM 17);

Alternative:

TNF-alpha convertase;Snake venom-like protease;TNF-alpha-converting enzyme;

CD:

CD156b;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with MAD2L1 and MUC1.

Function:

Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

824

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

824:

TRSEKAASFK | LQRQNRVDSK | ETEC

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000309968

String:

P78536

MIM:

603639

SMR:

P78536

Pfam:

PF00200

UniGene:

Hs.404914

KEGG:

hsa:6868

Uniprot:

P78536

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ELISA Kit for Human ADAM 17

Cat.:

E1319h

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Packing:

96T

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ELISA Kit for Human ADAM 17

Cat.:

E1319p

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96T

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ELISA Kit for Human ADAM 17

Cat.:

E1319m

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96T

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ELISA Kit for Human ADAM 17

Cat.:

E1319r

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96T

CLIA Kit for Human ADAM 17

Cat.:

U1319r

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Packing:

96T

CLIA Kit for Human ADAM 17

MSDS:

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CLIA Kit for Human ADAM 17

Cat.:

U1319h

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Manual:

Looking for manual.

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96T

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CLIA Kit for Human ADAM 17

Cat.:

U1319m

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Packing:

96T

Polyclonal Antibody for Human ADAM 17

Cat.:

P1319Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human ADAM 17

Cat.:

P1319Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human ADAM 17

Cat.:

P1319Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human ADAM 17

Protein for Human ADAM 17

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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Citations

[1].

"Demethylation of tumor necrosis factor-α converting enzyme predicts poor prognosis in acute-on-chronic hepatitis B liver failure"

Wang Z L, Gao S, Li L, et al

From:Clinics and research in hepatology and gastroenterology

References

1.

"Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha."
Moss M.L. , Jin S.-L.C. , Milla M.E. , Burkhart W. , Carter H.L. , Chen W.-J. , Clay W.C. , Didsbury J.R. , Hassler D. , Hoffman C.R. , Kost T.A. , Lambert M.H. , Leesnitzer M.A. , McCauley P. , McGeehan G. , Mitchell J. , Moyer M. , Pahel G. , more...
Nature385:733-736(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A);PARTIAL PROTEIN SEQUENCE
tissue: Leukocyte.
tissue: Monocyte.
2.

"A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells."
Black R.A. , Rauch C.T. , Kozlosky C.J. , Peschon J.J. , Slack J.L. , Wolfson M.F. , Castner B.J. , Stocking K.L. , Reddy P. , Srinivasan S. , Nelson N. , Bioani N. , Schooley K.A. , Gerhart M. , Davis R. , Fitzner J.N. , Johnson R.S. , Paxton R.J. , more...
Nature385:729-733(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)
3.

"TNF-alpha convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-alpha."
Patel I.R. , Attur M.G. , Patel R.N. , Stuchin S.A. , Abagyan R.A. , Abramson S.B. , Amin A.R.
J. Immunol.160:4570-4579(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)
tissue: Cartilage.
4.

"Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding."
Diaz-Rodriguez E. , Montero J.C. , Esparis-Ogando A. , Yuste L. , Pandiella A.
Mol. Biol. Cell13:2031-2044(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-735
5.

"Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding."
Thathiah A. , Blobel C.P. , Carson D.D.
J. Biol. Chem.278:3386-3394(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MUC1;FUNCTION
6.

"Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide."
Fan H. , Turck C.W. , Derynck R.
J. Biol. Chem.278:18617-18627(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-819
7.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-791;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
8.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-791;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
9.

"Junctional adhesion molecule-C is a soluble mediator of angiogenesis."
Rabquer B.J. , Amin M.A. , Teegala N. , Shaheen M.K. , Tsou P.S. , Ruth J.H. , Lesch C.A. , Imhof B.A. , Koch A.E.
J. Immunol.185:1777-1785(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ROLE IN PROTEOLYTICAL RELEASE OF JAM3
10.

"Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation."
Xu P. , Derynck R.
Mol. Cell37:551-566(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-735;INTERACTION WITH MAPK14
11.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-791;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
12.

"Inflammatory skin and bowel disease linked to ADAM17 deletion."
Blaydon D.C. , Biancheri P. , Di W.L. , Plagnol V. , Cabral R.M. , Brooke M.A. , van Heel D.A. , Ruschendorf F. , Toynbee M. , Walne A. , O'Toole E.A. , Martin J.E. , Lindley K. , Vulliamy T. , Abrams D.J. , MacDonald T.T. , Harper J.I. , Kelsell D.P.
N. Engl. J. Med.365:1502-1508(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN NISBD
13.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-791;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.

"The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality."
Boskovski M.T. , Yuan S. , Pedersen N.B. , Goth C.K. , Makova S. , Clausen H. , Brueckner M. , Khokha M.K.
Nature504:456-459(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
15.

"TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein."
Heurich A. , Hofmann-Winkler H. , Gierer S. , Liepold T. , Jahn O. , Poehlmann S.
J. Virol.88:1293-1307(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
16.

"Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme."
Maskos K. , Fernandez-Catalan C. , Huber R. , Bourenkov G.P. , Bartunik H. , Ellestad G.A. , Reddy P. , Wolfson M.F. , Rauch C.T. , Castner B.J. , Davis R. , Clarke H.R.G. , Petersen M. , Fitzner J.N. , Cerretti D.P. , March C.J. , Paxton R.J. , Black R.A. , more...
Proc. Natl. Acad. Sci. U.S.A.95:3408-3412(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 219-473;ACTIVE SITE

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