Disintegrin and metalloproteinase domain-containing protein 17 (Protein name
), ADA17_RAT from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Gene name:
Adam17(Tace);
Protein name:
Disintegrin and metalloproteinase domain-containing protein 17(ADAM 17);
Alternative:
TNF-alpha-converting enzyme;TNF-alpha convertase;
CD:
CD156b;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with MAD2L1 and MUC1.
Function:
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway.
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Precision
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Recovery
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Linearity
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References
1.
"Sequence analysis of rat TNF-alpha converting enzyme (TACE) cDNA." Hall L.
,
Beaumont A.J.
,
Jury J.A.
,
Frayne J.
Submitted (1998-11) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA]