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Index > Protein center > Eif2c2(Gene name) > Mouse
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  • Eif2c2 (Gene name),
  • Protein argonaute-2 (Protein name ),  AGO2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Eif2c2(Ago2;Kiaa4215);
    Protein name:
    Protein argonaute-2(Argonaute2;mAgo2);
    Alternative:
    Piwi/argonaute family protein meIF2C2(eIF-2C 2);Eukaryotic translation initiation factor 2C 2(eIF-2C 2;eIF2C 2);Protein slicer;Protein slicer;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with EIF2C1/AGO1. Also interacts with DDB1, DDX5, DDX6, DDX20, DHX30, DHX36, DDX47, DHX9, EIF6, ELAVL, FXR1, GEMIN4, HNRNPF, IGF2BP1, ILF3, IMP8, MATR3, MOV10, PABPC1, PRMT5, P4HA1, P4HB, RBM4, SART3, TNRC6A, TNRC6B, UPF1 and YBX1. Interacts with the P-body components DCP1A and XRN1. Associates with polysomes and messenger ribonucleoproteins (mNRPs). Interacts with RBM4; the interaction is modulated under stress-induced conditions, occurs under both cell proliferation and differentiation conditions and in a RNA- and phosphorylation-independent manner (By similarity). Interacts with DICER1 through its Piwi domain and with TARBP2 during assembly of the RNA-induced silencing complex (RISC). Together, DICER1, EIF2C2/AGO2 and TARBP2 constitute the trimeric RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC). Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Note however that the term RISC has also been used to describe the trimeric RLC/miRLC. The formation of RISC complexes containing siRNAs rather than miRNAs appears to occur independently of DICER1.
    Function:
    Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include EIF2C2/AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by EIF2C2/AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). May also upregulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and upregulates translation under conditions of serum starvation. May also be required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions. Regulates lymphoid and erythroid development and function, and this is independent of endonuclease activity.
    Subcellular Location:
    Cytoplasm P-body Nucleus Translational repression of mRNAs results in their recruitment to P-bodies. Translocation to the nucleus requires IMP8.
    Protein Attributes:
    Sequence length:
    860
    Sequence:
    50:
    MYSGAGPVLA | SPAPTTSPIP | GYAFKPPPRP | DFGTTGRTIK | LQANFFEMDI | 
    100:
    PKIDIYHYEL | DIKPEKCPRR | VNREIVEHMV | QHFKTQIFGD | RKPVFDGRKN | 
    150:
    LYTAMPLPIG | RDKVELEVTL | PGEGKDRIFK | VSIKWVSCVS | LQALHDALSG | 
    200:
    RLPSVPFETI | QALDVVMRHL | PSMRYTPVGR | SFFTASEGCS | NPLGGGREVW | 
    250:
    FGFHQSVRPS | LWKMMLNIDV | SATAFYKAQP | VIEFVCEVLD | FKSIEEQQKP | 
    300:
    LTDSQRVKFT | KEIKGLKVEI | THCGQMKRKY | RVCNVTRRPA | SHQTFPLQQE | 
    350:
    SGQTVECTVA | QYFKDRHKLV | LRYPHLPCLQ | VGQEQKHTYL | PLEVCNIVAG | 
    400:
    QRCIKKLTDN | QTSTMIRATA | RSAPDRQEEI | SKLMRSASFN | TDPYVREFGI | 
    450:
    MVKDEMTDVT | GRVLQPPSIL | YGGRNKAIAT | PVQGVWDMRN | KQFHTGIEIK | 
    500:
    VWAIACFAPQ | RQCTEVHLKS | FTEQLRKISR | DAGMPIQGQP | CFCKYAQGAD | 
    550:
    SVEPMFRHLK | NTYAGLQLVV | VILPGKTPVY | AEVKRVGDTV | LGMATQCVQM | 
    600:
    KNVQRTTPQT | LSNLCLKINV | KLGGVNNILL | PQGRPPVFQQ | PVIFLGADVT | 
    650:
    HPPAGDGKKP | SIAAVVGSMD | AHPNRYCATV | RVQQHRQEII | QDLAAMVREL | 
    700:
    LIQFYKSTRF | KPTRIIFYRD | GVSEGQFQQV | LHHELLAIRE | ACIKLEKDYQ | 
    750:
    PGITFIVVQK | RHHTRLFCTD | KNERVGKSGN | IPAGTTVDTK | ITHPTEFDFY | 
    800:
    LCSHAGIQGT | SRPSHYHVLW | DDNRFSSDEL | QILTYQLCHT | YVRCTRSVSI | 
    850:
    PAPAYYAHLV | AFRARYHLVD | KEHDSAEGSH | TSGQSNGRDH | QALAKAVQVH | 
    860:
    QDTLRTMYFA | 
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    UniGene:
    String:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Argonaute2
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    ELISA Kit for Mouse Argonaute2
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    ELISA Kit for Mouse Argonaute2
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    ELISA Kit for Mouse Argonaute2
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    CLIA Kit for Mouse Argonaute2
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    CLIA Kit for Mouse Argonaute2
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    CLIA Kit for Mouse Argonaute2
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    U11449h
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    CLIA Kit for Mouse Argonaute2
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    U11449r
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    CLIA Kit for Mouse Argonaute2
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    U11449b
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    96T
    Polyclonal Antibody for Mouse Argonaute2
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    P11449Rb-r
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    Packing:
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    Polyclonal Antibody for Mouse Argonaute2
    Polyclonal Antibody for Mouse Argonaute2
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    Polyclonal Antibody for Mouse Argonaute2
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    Packing:
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    Polyclonal Antibody for Mouse Argonaute2
    Monoclonal Antibody for Mouse Argonaute2
    Monoclonal Antibody for Mouse Argonaute2
    Monoclonal Antibody for Mouse Argonaute2
    Monoclonal Antibody for Mouse Argonaute2
    Monoclonal Antibody for Mouse Argonaute2
    Protein for Mouse Argonaute2
    Protein for Mouse Argonaute2
    Protein for Mouse Argonaute2
    Protein for Mouse Argonaute2
    Protein for Mouse Argonaute2

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    References
    1. 1.
      "Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors."
      Doi N. , Zenno S. , Ueda R. , Ohki-Hamazaki H. , Ui-Tei K. , Saigo K.
      Curr. Biol.13:41-46(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: B5/EGFP.
      tissue: Trophoblast stem cell.
    3. 3.
      "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N. , Kikuno R.F. , Ohara R. , Inamoto S. , Nagase T. , Ohara O. , Koga H.
      Submitted (2005-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 158-860
      tissue: Embryonic tail.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DISRUPTION PHENOTYPE
    5. 5.
      "A human, ATP-independent, RISC assembly machine fueled by pre-miRNA."
      Maniataki E. , Mourelatos Z.
      Genes Dev.19:2979-2990(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DICER1 AND TARBP2
    6. 6.
      "Endogenously nitrated proteins in mouse brain: links to neurodegenerative disease."
      Sacksteder C.A. , Qian W.-J. , Knyushko T.V. , Wang H. , Chin M.H. , Lacan G. , Melega W.P. , Camp D.G. II , Smith R.D. , Smith D.J. , Squier T.C. , Bigelow D.J.
      Biochemistry45:8009-8022(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NITRATION [LARGE SCALE ANALYSIS] AT TYR-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Brain.
    7. 7.
      "A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway."
      O'Carroll D. , Mecklenbrauker I. , Das P.P. , Santana A. , Koenig U. , Enright A.J. , Miska E.A. , Tarakhovsky A.
      Genes Dev.21:1999-2004(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    8. 8.
      "Essential and overlapping functions for mammalian Argonautes in microRNA silencing."
      Su H. , Trombly M.I. , Chen J. , Wang X.
      Genes Dev.23:304-317(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      "The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2."
      Rybak A. , Fuchs H. , Hadian K. , Smirnova L. , Wulczyn E.A. , Michel G. , Nitsch R. , Krappmann D. , Wulczyn F.G.
      Nat. Cell Biol.11:1411-1420(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRIM71
    10. 10.
      "The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling."
      Chen J. , Lai F. , Niswander L.
      Genes Dev.26:803-815(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRIM71
    11. 11.
      "Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation."
      Chang H.M. , Martinez N.J. , Thornton J.E. , Hagan J.P. , Nguyen K.D. , Gregory R.I.
      Nat. Commun.3:923-923(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRIM71
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