Gene name:
AKR1A1 (ALDR1;ALR) ;
Protein name:
Alcohol dehydrogenase [NADP+] ;
Alternative:
Aldo-keto reductase family 1 member A1 ;Aldehyde reductase ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).
Subcellular Location:
N/A
Protein Attributes:
50:
MAASCVLLHT | GQKMPLIGLG | TWKSEPGQVK | AAVKYALSVG | YRHIDCAAIY |
100:
GNEPEIGEAL | KEDVGPGKAV | PREELFVTSK | LWNTKHHPED | VEPALRKTLA |
150:
DLQLEYLDLY | LMHWPYAFER | GDNPFPKNAD | GTICYDSTHY | KETWKALEAL |
200:
VAKGLVQALG | LSNFNSRQID | DILSVASVRP | AVLQVECHPY | LAQNELIAHC |
250:
QARGLEVTAY | SPLGSSDRAW | RDPDEPVLLE | EPVVLALAEK | YGRSPAQILL |
300:
RWQVQRKVIC | IPKSITPSRI | LQNIKVFDFT | FSPEEMKQLN | ALNKNWRYIV |
325:
PMLTVDGKRV | PRDAGHPLYP | FNDPY
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Chicken
Pig
Human
Mouse
Rat
ELISA Kit for Human Alcohol dehydrogenase [NADP+]
ELISA Kit for Human Alcohol dehydrogenase [NADP+]
ELISA Kit for Human Alcohol dehydrogenase [NADP+]
ELISA Kit for Human Alcohol dehydrogenase [NADP+]
ELISA Kit for Human Alcohol dehydrogenase [NADP+]
ELISA Kit for Human Alcohol dehydrogenase [NADP+]
CLIA Kit for Human Alcohol dehydrogenase [NADP+]
CLIA Kit for Human Alcohol dehydrogenase [NADP+]
CLIA Kit for Human Alcohol dehydrogenase [NADP+]
CLIA Kit for Human Alcohol dehydrogenase [NADP+]
CLIA Kit for Human Alcohol dehydrogenase [NADP+]
CLIA Kit for Human Alcohol dehydrogenase [NADP+]
Polyclonal Antibody for Human Alcohol dehydrogenase [NADP+]
Polyclonal Antibody for Human Alcohol dehydrogenase [NADP+]
Polyclonal Antibody for Human Alcohol dehydrogenase [NADP+]
Polyclonal Antibody for Human Alcohol dehydrogenase [NADP+]
Polyclonal Antibody for Human Alcohol dehydrogenase [NADP+]
Polyclonal Antibody for Human Alcohol dehydrogenase [NADP+]
Monoclonal Antibody for Human Alcohol dehydrogenase [NADP+]
Monoclonal Antibody for Human Alcohol dehydrogenase [NADP+]
Monoclonal Antibody for Human Alcohol dehydrogenase [NADP+]
Monoclonal Antibody for Human Alcohol dehydrogenase [NADP+]
Monoclonal Antibody for Human Alcohol dehydrogenase [NADP+]
Monoclonal Antibody for Human Alcohol dehydrogenase [NADP+]
Protein for Human Alcohol dehydrogenase [NADP+]
Protein for Human Alcohol dehydrogenase [NADP+]
Protein for Human Alcohol dehydrogenase [NADP+]
Protein for Human Alcohol dehydrogenase [NADP+]
Protein for Human Alcohol dehydrogenase [NADP+]
Protein for Human Alcohol dehydrogenase [NADP+]
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
tissue :
Liver .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
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[
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Uterus .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
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Rogers J.
,
Bentley D.R.
more...
Nature441:315-321(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Colon .
tissue :
Kidney .
10.
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Cited for : PROTEIN SEQUENCE OF 2-325
tissue :
Liver .
11.
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Cited for : MUTAGENESIS OF TYR-50; LYS-80; HIS-113; ILE-299 AND VAL-300
12.
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Cited for : FUNCTION;TISSUE SPECIFICITY
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;TISSUE SPECIFICITY
14.
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Cited for : FUNCTION;CHARACTERIZATION OF VARIANTS SER-52 AND ASP-55
15.
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Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
16.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.48 ANGSTROMS)