AKT1 ELISA Kit for Bovine(Bos taurus) | EIAab.comAKT1 ELISA Kit for Bovine(Bos taurus)

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AKT1 (Gene name),

RAC-alpha serine/threonine-protein kinase (Protein name ), AKT1_BOVIN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

AKT1(PKB);

Protein name:

RAC-alpha serine/threonine-protein kinase;

Alternative:

Protein kinase B alpha(PKB alpha);Protein kinase B(PKB);RAC-PK-alpha;

Organism:

Bovine (Bos taurus).

General Annotation

Sub Unit:

Interacts (via the C-terminus) with CCDC88A (via its C-terminus) and THEM4 (via its C-terminus). Interacts with AKTIP. Interacts (via PH domain) with MTCP1, TCL1A AND TCL1B. Interacts with TRAF6. Interacts with GRB10; the interaction leads to GRB10 phosphorylation thus promoting YWHAE binding. Interacts with RARA; the interaction phosphorylates RARA and represses its transactivation activity (By similarity). Interacts with MAP3K5 and TNK2 (By similarity). Interacts with CLK2 and PPP2R5B (By similarity). Interacts with STK3/MST2 and STK4/MST1.

Function:

AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation.

Subcellular Location:

Cytoplasm Nucleus Cell membrane Nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A (By similarity). Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form translocates to the nucleus.

Protein Attributes:

Sequence length:

480

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

480:

PPDQDDSMEG | VDSERRPHFP | QFSYSASATA |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9913.ENSBTAP00000051717

SMR:

Q01314

Pfam:

PF00169

String:

Q01314

KEGG:

bta:280991

UniGene:

Bt.4843

Uniprot:

Q01314

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ELISA Kit for Bovine RAC-alpha serine/threonine-protein kinase

Cat.:

E0382r

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96T

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ELISA Kit for Bovine RAC-alpha serine/threonine-protein kinase

Cat.:

E0382h

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96T

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ELISA Kit for Bovine RAC-alpha serine/threonine-protein kinase

Cat.:

E0382m

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ELISA Kit for Bovine RAC-alpha serine/threonine-protein kinase

Cat.:

E0382b

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96T

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CLIA Kit for Bovine RAC-alpha serine/threonine-protein kinase

Cat.:

U0382b

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Packing:

96T

CLIA Kit for Bovine RAC-alpha serine/threonine-protein kinase

Cat.:

U0382m

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Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Bovine RAC-alpha serine/threonine-protein kinase

Cat.:

U0382h

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Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

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CLIA Kit for Bovine RAC-alpha serine/threonine-protein kinase

Cat.:

U0382r

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MSDS:

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Packing:

96T

Polyclonal Antibody for Bovine RAC-alpha serine/threonine-protein kinase

Cat.:

P0382Rb-h

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40ug/0.2ml

Polyclonal Antibody for Bovine RAC-alpha serine/threonine-protein kinase

Cat.:

P0382Rb-m

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40ug/0.2ml

Polyclonal Antibody for Bovine RAC-alpha serine/threonine-protein kinase

Cat.:

P0382Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Bovine RAC-alpha serine/threonine-protein kinase

Monoclonal Antibody for Bovine RAC-alpha serine/threonine-protein kinase

Protein for Bovine RAC-alpha serine/threonine-protein kinase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families."
Coffer P.J. , Woodgett J.R.
Eur. J. Biochem.201:475-481(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
2.

Coffer P.J. , Woodgett J.R.
Eur. J. Biochem.205:1217-1218(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM;SEQUENCE REVISION
3.

"Complete sequence of the bovine AKT1 gene."
Khatib H.
Submitted (2004-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
4.

"PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth."
Gao T. , Furnari F. , Newton A.C.
Mol. Cell18:13-24(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEPHOSPHORYLATION AT SER-473 BY PHLPP

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