Gene name:
AKT1 (PKB;RAC) ;
Protein name:
RAC-alpha serine/threonine-protein kinase ;
Alternative:
Protein kinase B alpha (PKB alpha) ;Protein kinase B (PKB) ;RAC-PK-alpha ;Proto-oncogene c-Akt ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with AGAP2 (isoform 2, PIKE-A), the interaction requires guanine nucleotides and stimulates the kinase activity. Interacts (via the C-terminus) with CCDC88A (via its C-terminus) and THEM4 (via its C-terminus). Interacts with AKTIP. Interacts (via PH domain) with MTCP1, TCL1A AND TCL1B. Interacts with MAP3K5 and TRAF6. Interacts with GRB10; the interaction leads to GRB10 phosphorylation thus promoting YWHAE binding. Interacts with RARA; the interaction phosphorylates RARA and represses its transactivation activity. Interacts with TNK2. Interacts with CLK2 and PPP2R5B. Interacts with STK3/MST2 and STK4/MST1.
Function:
AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation.
Subcellular Location:
Cytoplasm
Nucleus
Cell membrane
Nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form translocates to the nucleus.
Protein Attributes:
50:
MSDVAIVKEG | WLHKRGEYIK | TWRPRYFLLK | NDGTFIGYKE | RPQDVDQREA |
100:
PLNNFSVAQC | QLMKTERPRP | NTFIIRCLQW | TTVIERTFHV | ETPEEREEWT |
150:
TAIQTVADGL | KKQEEEEMDF | RSGSPSDNSG | AEEMEVSLAK | PKHRVTMNEF |
200:
EYLKLLGKGT | FGKVILVKEK | ATGRYYAMKI | LKKEVIVAKD | EVAHTLTENR |
250:
VLQNSRHPFL | TALKYSFQTH | DRLCFVMEYA | NGGELFFHLS | RERVFSEDRA |
300:
RFYGAEIVSA | LDYLHSEKNV | VYRDLKLENL | MLDKDGHIKI | TDFGLCKEGI |
350:
KDGATMKTFC | GTPEYLAPEV | LEDNDYGRAV | DWWGLGVVMY | EMMCGRLPFY |
400:
NQDHEKLFEL | ILMEEIRFPR | TLGPEAKSLL | SGLLKKDPKQ | RLGGGSEDAK |
450:
EIMQHRFFAG | IVWQHVYEKK | LSPPFKPQVT | SETDTRYFDE | EFTAQMITIT |
480:
PPDQDDSMEC | VDSERRPHFP | QFSYSASGTA |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
Bovine
ELISA Kit for Human RAC-alpha serine/threonine-protein kinase
ELISA Kit for Human RAC-alpha serine/threonine-protein kinase
ELISA Kit for Human RAC-alpha serine/threonine-protein kinase
ELISA Kit for Human RAC-alpha serine/threonine-protein kinase
CLIA Kit for Human RAC-alpha serine/threonine-protein kinase
CLIA Kit for Human RAC-alpha serine/threonine-protein kinase
CLIA Kit for Human RAC-alpha serine/threonine-protein kinase
CLIA Kit for Human RAC-alpha serine/threonine-protein kinase
Polyclonal Antibody for Human RAC-alpha serine/threonine-protein kinase
Polyclonal Antibody for Human RAC-alpha serine/threonine-protein kinase
Polyclonal Antibody for Human RAC-alpha serine/threonine-protein kinase
Polyclonal Antibody for Human RAC-alpha serine/threonine-protein kinase
Monoclonal Antibody for Human RAC-alpha serine/threonine-protein kinase
Monoclonal Antibody for Human RAC-alpha serine/threonine-protein kinase
Monoclonal Antibody for Human RAC-alpha serine/threonine-protein kinase
Monoclonal Antibody for Human RAC-alpha serine/threonine-protein kinase
Protein for Human RAC-alpha serine/threonine-protein kinase
Protein for Human RAC-alpha serine/threonine-protein kinase
Protein for Human RAC-alpha serine/threonine-protein kinase
Protein for Human RAC-alpha serine/threonine-protein kinase
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);CATALYTIC ACTIVITY
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
,
Suzuki Y.
,
Nishikawa T.
,
Otsuki T.
,
Sugiyama T.
,
Irie R.
,
Wakamatsu A.
,
Hayashi K.
,
Sato H.
,
Nagai K.
,
Kimura K.
,
Makita H.
,
Sekine M.
,
Obayashi M.
,
Nishi T.
,
Shibahara T.
,
Tanaka T.
,
Ishii S.
,
Yamamoto J.
,
Saito K.
,
Kawai Y.
,
Isono Y.
,
Nakamura Y.
,
Nagahari K.
,
Murakami K.
,
Yasuda T.
,
Iwayanagi T.
,
Wagatsuma M.
,
Shiratori A.
,
Sudo H.
,
Hosoiri T.
,
Kaku Y.
,
Kodaira H.
,
Kondo H.
,
Sugawara M.
,
Takahashi M.
,
Kanda K.
,
Yokoi T.
,
Furuya T.
,
Kikkawa E.
,
Omura Y.
,
Abe K.
,
Kamihara K.
,
Katsuta N.
,
Sato K.
,
Tanikawa M.
,
Yamazaki M.
,
Ninomiya K.
,
Ishibashi T.
,
Yamashita H.
,
Murakawa K.
,
Fujimori K.
,
Tanai H.
,
Kimata M.
,
Watanabe M.
,
Hiraoka S.
,
Chiba Y.
,
Ishida S.
,
Ono Y.
,
Takiguchi S.
,
Watanabe S.
,
Yosida M.
,
Hotuta T.
,
Kusano J.
,
Kanehori K.
,
Takahashi-Fujii A.
,
Hara H.
,
Tanase T.-O.
,
Nomura Y.
,
Togiya S.
,
Komai F.
,
Hara R.
,
Takeuchi K.
,
Arita M.
,
Imose N.
,
Musashino K.
,
Yuuki H.
,
Oshima A.
,
Sasaki N.
,
Aotsuka S.
,
Yoshikawa Y.
,
Matsunawa H.
,
Ichihara T.
,
Shiohata N.
,
Sano S.
,
Moriya S.
,
Momiyama H.
,
Satoh N.
,
Takami S.
,
Terashima Y.
,
Suzuki O.
,
Nakagawa S.
,
Senoh A.
,
Mizoguchi H.
,
Goto Y.
,
Shimizu F.
,
Wakebe H.
,
Hishigaki H.
,
Watanabe T.
,
Sugiyama A.
,
Takemoto M.
,
Kawakami B.
,
Yamazaki M.
,
Watanabe K.
,
Kumagai A.
,
Itakura S.
,
Fukuzumi Y.
,
Fujimori Y.
,
Komiyama M.
,
Tashiro H.
,
Tanigami A.
,
Fujiwara T.
,
Ono T.
,
Yamada K.
,
Fujii Y.
,
Ozaki K.
,
Hirao M.
,
Ohmori Y.
,
Kawabata A.
,
Hikiji T.
,
Kobatake N.
,
Inagaki H.
,
Ikema Y.
,
Okamoto S.
,
Okitani R.
,
Kawakami T.
,
Noguchi S.
,
Itoh T.
,
Shigeta K.
,
Senba T.
,
Matsumura K.
,
Nakajima Y.
,
Mizuno T.
,
Morinaga M.
,
Sasaki M.
,
Togashi T.
,
Oyama M.
,
Hata H.
,
Watanabe M.
,
Komatsu T.
,
Mizushima-Sugano J.
,
Satoh T.
,
Shirai Y.
,
Takahashi Y.
,
Nakagawa K.
,
Okumura K.
,
Nagase T.
,
Nomura N.
,
Kikuchi H.
,
Masuho Y.
,
Yamashita R.
,
Nakai K.
,
Yada T.
,
Nakamura Y.
,
Ohara O.
,
Isogai T.
,
Sugano S.
more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue :
Adrenal gland .
4.
"Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
Goshima N.
,
Kawamura Y.
,
Fukumoto A.
,
Miura A.
,
Honma R.
,
Satoh R.
,
Wakamatsu A.
,
Yamamoto J.
,
Kimura K.
,
Nishikawa T.
,
Andoh T.
,
Iida Y.
,
Ishikawa K.
,
Ito E.
,
Kagawa N.
,
Kaminaga C.
,
Kanehori K.
,
Kawakami B.
,
Kenmochi K.
,
Kimura R.
,
Kobayashi M.
,
Kuroita T.
,
Kuwayama H.
,
Maruyama Y.
,
Matsuo K.
,
Minami K.
,
Mitsubori M.
,
Mori M.
,
Morishita R.
,
Murase A.
,
Nishikawa A.
,
Nishikawa S.
,
Okamoto T.
,
Sakagami N.
,
Sakamoto Y.
,
Sasaki Y.
,
Seki T.
,
Sono S.
,
Sugiyama A.
,
Sumiya T.
,
Takayama T.
,
Takayama Y.
,
Takeda H.
,
Togashi T.
,
Yahata K.
,
Yamada H.
,
Yanagisawa Y.
,
Endo Y.
,
Imamoto F.
,
Kisu Y.
,
Tanaka S.
,
Isogai T.
,
Imai J.
,
Watanabe S.
,
Nomura N.
more...
Nat. Methods5:1011-1017(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
5.
"The DNA sequence and analysis of human chromosome 14."
Heilig R.
,
Eckenberg R.
,
Petit J.-L.
,
Fonknechten N.
,
Da Silva C.
,
Cattolico L.
,
Levy M.
,
Barbe V.
,
De Berardinis V.
,
Ureta-Vidal A.
,
Pelletier E.
,
Vico V.
,
Anthouard V.
,
Rowen L.
,
Madan A.
,
Qin S.
,
Sun H.
,
Du H.
,
Pepin K.
,
Artiguenave F.
,
Robert C.
,
Cruaud C.
,
Bruels T.
,
Jaillon O.
,
Friedlander L.
,
Samson G.
,
Brottier P.
,
Cure S.
,
Segurens B.
,
Aniere F.
,
Samain S.
,
Crespeau H.
,
Abbasi N.
,
Aiach N.
,
Boscus D.
,
Dickhoff R.
,
Dors M.
,
Dubois I.
,
Friedman C.
,
Gouyvenoux M.
,
James R.
,
Madan A.
,
Mairey-Estrada B.
,
Mangenot S.
,
Martins N.
,
Menard M.
,
Oztas S.
,
Ratcliffe A.
,
Shaffer T.
,
Trask B.
,
Vacherie B.
,
Bellemere C.
,
Belser C.
,
Besnard-Gonnet M.
,
Bartol-Mavel D.
,
Boutard M.
,
Briez-Silla S.
,
Combette S.
,
Dufosse-Laurent V.
,
Ferron C.
,
Lechaplais C.
,
Louesse C.
,
Muselet D.
,
Magdelenat G.
,
Pateau E.
,
Petit E.
,
Sirvain-Trukniewicz P.
,
Trybou A.
,
Vega-Czarny N.
,
Bataille E.
,
Bluet E.
,
Bordelais I.
,
Dubois M.
,
Dumont C.
,
Guerin T.
,
Haffray S.
,
Hammadi R.
,
Muanga J.
,
Pellouin V.
,
Robert D.
,
Wunderle E.
,
Gauguet G.
,
Roy A.
,
Sainte-Marthe L.
,
Verdier J.
,
Verdier-Discala C.
,
Hillier L.W.
,
Fulton L.
,
McPherson J.
,
Matsuda F.
,
Wilson R.
,
Scarpelli C.
,
Gyapay G.
,
Wincker P.
,
Saurin W.
,
Quetier F.
,
Waterston R.
,
Hood L.
,
Weissenbach J.
more...
Nature421:601-607(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Muscle .
tissue :
Ovary .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 63-480 (ISOFORM 1);FUNCTION;CATALYTIC ACTIVITY;TISSUE SPECIFICITY
tissue :
Foreskin .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ERRATUM;SEQUENCE REVISION
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PHOSPHORYLATION OF CREB1
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ENZYME REGULATION;PHOSPHORYLATION AT SER-473
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : MUTAGENESIS OF THR-308 AND SER-473;PHOSPHORYLATION AT THR-308 AND SER-473
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;ENZYME REGULATION;PHOSPHORYLATION AT THR-308 BY PDPK1
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PHOSPHORYLATION OF FOXO1
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PHOSPHORYLATION OF RAF1;INTERACTION WITH RAF1
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PHOSPHORYLATION OF BAD;INTERACTION WITH BAD AND PKN2
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MTCP1; TCL1A AND TCL1B
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TCL1A
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PHOSPHORYLATION OF MAP3K5;INTERACTION WITH MAP3K5
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH THEM4;SUBCELLULAR LOCATION
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PHOSPHORYLATION OF TBC1D4
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CDKN1B;FUNCTION
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT TYR-474;MUTAGENESIS OF TYR-474
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PHOSPHORYLATION OF TSC2
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TCL1A
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CDKN1B;FUNCTION;MUTAGENESIS OF THR-308 AND SER-473
26.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PARTICIPATION IN KIT SIGNALING
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH AGAP2;PHOSPHORYLATION AT SER-473
28.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-473
29.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ERRATUM
30.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH AKTIP
31.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH AGAP2
32.
"Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation."
Brandts C.H.
,
Sargin B.
,
Rode M.
,
Biermann C.
,
Lindtner B.
,
Schwable J.
,
Buerger H.
,
Muller-Tidow C.
,
Choudhary C.
,
McMahon M.
,
Berdel W.E.
,
Serve H.
Cancer Res.65:9643-9650(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-473 IN RESPONSE TO FLT3 SIGNALING
33.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;CATALYTIC ACTIVITY;INTERACTION WITH CCDC88A
34.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT THR-308;PHOSPHORYLATION AT SER-473 BY MTOR
35.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-473
36.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH RARA
37.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
38.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : BIOPHYSICOCHEMICAL PROPERTIES
39.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PHOSPHORYLATION OF CDKN1A
40.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH STK4/MST1;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
41.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH STK4/MST1
42.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PHOSPHORYLATION OF PROHIBITIN
43.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-124; SER-126 AND SER-129;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
44.
"The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt."
Suizu F.
,
Hiramuki Y.
,
Okumura F.
,
Matsuda M.
,
Okumura A.J.
,
Hirata N.
,
Narita M.
,
Kohno T.
,
Yokota J.
,
Bohgaki M.
,
Obuse C.
,
Hatakeyama S.
,
Obata T.
,
Noguchi M.
Dev. Cell17:800-810(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : UBIQUITINATION BY TTC3
45.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PHOSPHORYLATION OF SRPK2;INTERACTION WITH SRPK2
46.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
47.
"The E3 ligase TRAF6 regulates Akt ubiquitination and activation."
Yang W.-L.
,
Wang J.
,
Chan C.-H.
,
Lee S.-W.
,
Campos A.D.
,
Lamothe B.
,
Hur L.
,
Grabiner B.C.
,
Lin X.
,
Darnay B.G.
,
Lin H.-K.
Science325:1134-1138(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : UBIQUITINATION;INTERACTION WITH TRAF6;MUTAGENESIS OF LYS-8 AND LYS-14;CHARACTERIZATION OF VARIANT BREAST CANCER LYS-17
48.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH STK3/MST2
49.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
50.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH CLK2
51.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PHOSPHORYLATION OF PALLD
52.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH STK3/MST2
53.
"Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation."
Mahajan K.
,
Coppola D.
,
Challa S.
,
Fang B.
,
Chen Y.A.
,
Zhu W.
,
Lopez A.S.
,
Koomen J.
,
Engelman R.W.
,
Rivera C.
,
Muraoka-Cook R.S.
,
Cheng J.Q.
,
Schoenbrunn E.
,
Sebti S.M.
,
Earp H.S.
,
Mahajan N.P.
PLoS ONE5:E9646-E9646(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION AT TYR-176; THR-308 AND SER-473;MUTAGENESIS OF TYR-176;INTERACTION WITH TNK2;TISSUE SPECIFICITY
54.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
55.
"Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2."
Joo H.M.
,
Kim J.Y.
,
Jeong J.B.
,
Seong K.M.
,
Nam S.Y.
,
Yang K.H.
,
Kim C.S.
,
Kim H.S.
,
Jeong M.
,
An S.
,
Jin Y.W.
Eur. J. Cell Biol.90:420-431(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TRIM13;UBIQUITINATION
56.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PPP2R5B;DEPHOSPHORYLATION
57.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON ROLE IN KIT SIGNALING
58.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON FUNCTION
59.
"A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells."
Kunoh T.
,
Noda T.
,
Koseki K.
,
Sekigawa M.
,
Takagi M.
,
Shin-ya K.
,
Goshima N.
,
Iemura S.
,
Natsume T.
,
Wada S.
,
Mukai Y.
,
Ohta S.
,
Sasaki R.
,
Mizukami T.
Mol. Cancer Ther.9:2934-2942(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-473
60.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON FUNCTION
61.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON FUNCTION
62.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT THR-308 AND SER-473
63.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SIRT1;ACETYLATION AT LYS-14 AND LYS-20;DEACETYLATION AT LYS-14 AND LYS-20;MUTAGENESIS OF LYS-14; GLU-17 AND LYS-20
64.
"Akt is negatively regulated by the MULAN E3 ligase."
Bae S.
,
Kim S.Y.
,
Jung J.H.
,
Yoon Y.
,
Cha H.J.
,
Lee H.
,
Kim K.
,
Kim J.
,
An I.S.
,
Kim J.
,
Um H.D.
,
Park I.C.
,
Lee S.J.
,
Nam S.Y.
,
Jin Y.W.
,
Lee J.H.
,
An S.
Cell Res.22:873-885(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : UBIQUITINATION AT LYS-284
65.
"Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates Akt signaling."
Wang S.
,
Huang X.
,
Sun D.
,
Xin X.
,
Pan Q.
,
Peng S.
,
Liang Z.
,
Luo C.
,
Yang Y.
,
Jiang H.
,
Huang M.
,
Chai W.
,
Ding J.
,
Geng M.
PLoS ONE7:E37427-E37427(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION AT SER-126; SER-129; THR-305 AND THR-312;SUBCELLULAR LOCATION;INTERACTION WITH PDPK1;MUTAGENESIS OF THR-305 AND THR-312
66.
"CSTP1, a novel protein phosphatase, blocks cell cycle, promotes cell apoptosis, and suppresses tumor growth of bladder cancer by directly dephosphorylating Akt at Ser473 site."
Zhuo D.X.
,
Zhang X.W.
,
Jin B.
,
Zhang Z.
,
Xie B.S.
,
Wu C.L.
,
Gong K.
,
Mao Z.B.
PLoS ONE8:E65679-E65679(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-473;DEPHOSPHORYLATION BY CPPED1
67.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
68.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 1-123;INTERACTION WITH PTDINS(3,4,5)P3 AND PTDINS(3,4)P2;MUTAGENESIS OF LYS-14; ARG-25 AND ARG-86
69.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (0.98 ANGSTROMS) OF 1-121;INTERACTION WITH PTDINS(1,3,4,5)P4
70.
"Synthesis and structure based optimization of novel Akt inhibitors."
Lippa B.
,
Pan G.
,
Corbett M.
,
Li C.
,
Kauffman G.S.
,
Pandit J.
,
Robinson S.
,
Wei L.
,
Kozina E.
,
Marr E.S.
,
Borzillo G.
,
Knauth E.
,
Barbacci-Tobin E.G.
,
Vincent P.
,
Troutman M.
,
Baker D.
,
Rajamohan F.
,
Kakar S.
,
Clark T.
,
Morris J.
more...
Bioorg. Med. Chem. Lett.18:3359-3363(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 144-480;PHOSPHORYLATION AT THR-308;ENZYME REGULATION
71.
"Discovery of pyrrolopyrimidine inhibitors of Akt."
Blake J.F.
,
Kallan N.C.
,
Xiao D.
,
Xu R.
,
Bencsik J.R.
,
Skelton N.J.
,
Spencer K.L.
,
Mitchell I.S.
,
Woessner R.D.
,
Gloor S.L.
,
Risom T.
,
Gross S.D.
,
Martinson M.
,
Morales T.H.
,
Vigers G.P.
,
Brandhuber B.J.
Bioorg. Med. Chem. Lett.20:5607-5612(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 144-480;ENZYME REGULATION
72.
"Design of selective, ATP-competitive inhibitors of Akt."
Freeman-Cook K.D.
,
Autry C.
,
Borzillo G.
,
Gordon D.
,
Barbacci-Tobin E.
,
Bernardo V.
,
Briere D.
,
Clark T.
,
Corbett M.
,
Jakubczak J.
,
Kakar S.
,
Knauth E.
,
Lippa B.
,
Luzzio M.J.
,
Mansour M.
,
Martinelli G.
,
Marx M.
,
Nelson K.
,
Pandit J.
,
Rajamohan F.
,
Robinson S.
,
Subramanyam C.
,
Wei L.
,
Wythes M.
,
Morris J.
more...
J. Med. Chem.53:4615-4622(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.01 ANGSTROMS) OF 144-480;PHOSPHORYLATION AT THR-308;ENZYME REGULATION
73.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 2-443;DISULFIDE BOND
74.
"Discovery and SAR of spirochromane Akt inhibitors."
Kallan N.C.
,
Spencer K.L.
,
Blake J.F.
,
Xu R.
,
Heizer J.
,
Bencsik J.R.
,
Mitchell I.S.
,
Gloor S.L.
,
Martinson M.
,
Risom T.
,
Gross S.D.
,
Morales T.H.
,
Wu W.I.
,
Vigers G.P.
,
Brandhuber B.J.
,
Skelton N.J.
Bioorg. Med. Chem. Lett.21:2410-2414(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 144-480;ENZYME REGULATION
75.
"A transforming mutation in the pleckstrin homology domain of AKT1 in cancer."
Carpten J.D.
,
Faber A.L.
,
Horn C.
,
Donoho G.P.
,
Briggs S.L.
,
Robbins C.M.
,
Hostetter G.
,
Boguslawski S.
,
Moses T.Y.
,
Savage S.
,
Uhlik M.
,
Lin A.
,
Du J.
,
Qian Y.-W.
,
Zeckner D.J.
,
Tucker-Kellogg G.
,
Touchman J.
,
Patel K.
,
Mousses S.
,
Bittner M.
,
Schevitz R.
,
Lai M.-H.T.
,
Blanchard K.L.
,
Thomas J.E.
more...
Nature448:439-444(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT BREAST CANCER LYS-17;CHARACTERIZATION OF VARIANT BREAST CANCER LYS-17
76.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHARACTERIZATION OF VARIANT PROTEUSS LYS-17
77.
"A mosaic activating mutation in AKT1 associated with the Proteus syndrome."
Lindhurst M.J.
,
Sapp J.C.
,
Teer J.K.
,
Johnston J.J.
,
Finn E.M.
,
Peters K.
,
Turner J.
,
Cannons J.L.
,
Bick D.
,
Blakemore L.
,
Blumhorst C.
,
Brockmann K.
,
Calder P.
,
Cherman N.
,
Deardorff M.A.
,
Everman D.B.
,
Golas G.
,
Greenstein R.M.
,
Kato B.M.
,
Keppler-Noreuil K.M.
,
Kuznetsov S.A.
,
Miyamoto R.T.
,
Newman K.
,
Ng D.
,
O'Brien K.
,
Rothenberg S.
,
Schwartzentruber D.J.
,
Singhal V.
,
Tirabosco R.
,
Upton J.
,
Wientroub S.
,
Zackai E.H.
,
Hoag K.
,
Whitewood-Neal T.
,
Robey P.G.
,
Schwartzberg P.L.
,
Darling T.N.
,
Tosi L.L.
,
Mullikin J.C.
,
Biesecker L.G.
more...
N. Engl. J. Med.365:611-619(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PROTEUSS LYS-17
78.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS CWD6 CYS-25 AND PRO-435