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Index > Protein center > Aph1a(Gene name) > Mouse
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  • Aph1a (Gene name),
  • Gamma-secretase subunit APH-1A (Protein name ),  APH1A_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Aph1a;
    Protein name:
    Gamma-secretase subunit APH-1A(APH-1a);
    Alternative:
    Aph-1alpha;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist.
    Function:
    Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
    Subcellular Location:
    Endoplasmic reticulum membrane Multi-pass membrane protein Golgi apparatus cis-Golgi network membrane Multi-pass membrane protein Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
    Protein Attributes:
    Sequence length:
    265
    Sequence:
    50:
    MGAAVFFGCT | FVAFGPAFSL | FLITVAGDPL | RVIILVAGAF | FWLVSLLLAS | 
    100:
    VVWFILVHVT | DRSDARLQYG | LLIFGAAVSV | LLQEVFRFAY | YKLLKKADEG | 
    150:
    LASLSEDGRS | PISIRQMAYV | SGLSFGIISG | VFSVINILAD | ALGPGVVGIH | 
    200:
    GDSPYYFLTS | AFLTAAIILL | HTFWGVVFFD | ACERRRYWAL | GLVVGSHLLT | 
    250:
    SGLTFLNPWY | EASLLPIYAV | TVSMGLWAFI | TAGGSLRSIQ | RSLSCRRQED | 
    265:
    SRVMVYSALR | IPPED
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse APH-1a
    Cat.:
    E0406m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse APH-1a
    Cat.:
    E0406h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse APH-1a
    Cat.:
    U0406h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse APH-1a
    Cat.:
    U0406m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Mouse APH-1a
    Cat.:
    P0406Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse APH-1a
    Cat.:
    P0406Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse APH-1a
    Monoclonal Antibody for Mouse APH-1a
    Protein for Mouse APH-1a
    Protein for Mouse APH-1a

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Liver.
      tissue: Mammary tumor.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 97-265 (ISOFORM 2)
      strain: C57BL/6J.
      tissue: Cerebellum.
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