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Index > Protein center > AQP4(Gene name) > Human
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  • AQP4 (Gene name),
  • Aquaporin-4 (Protein name ),  AQP4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    AQP4;
    Protein name:
    Aquaporin-4(AQP-4);
    Alternative:
    WCH4;Mercurial-insensitive water channel(MIWC);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotetramer.
    Function:
    Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    323
    Sequence:
    50:
    MSDRPTARRW | GKCGPLCTRE | NIMVAFKGVW | TQAFWKAVTA | EFLAMLIFVL | 
    100:
    LSLGSTINWG | GTEKPLPVDM | VLISLCFGLS | IATMVQCFGH | ISGGHINPAV | 
    150:
    TVAMVCTRKI | SIAKSVFYIA | AQCLGAIIGA | GILYLVTPPS | VVGGLGVTMV | 
    200:
    HGNLTAGHGL | LVELIITFQL | VFTIFASCDS | KRTDVTGSIA | LAIGFSVAIG | 
    250:
    HLFAINYTGA | SMNPARSFGP | AVIMGNWENH | WIYWVGPIIG | AVLAGGLYEY | 
    300:
    VFCPDVEFKR | RFKEAFSKAA | QQTKGSYMEV | EDNRSQVETD | DLILKPGVVH | 
    323:
    VIDVDRGEEK | KGKDQSGEVL | SSV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    String:
    SMR:
    UniGene:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human AQP-4
    Cat.:
    E0582h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human AQP-4
    Cat.:
    E0582m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human AQP-4
    Cat.:
    E0582b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human AQP-4
    Cat.:
    E0582r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human AQP-4
    Cat.:
    U0582r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human AQP-4
    Cat.:
    U0582b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human AQP-4
    Cat.:
    U0582m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human AQP-4
    Cat.:
    U0582h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human AQP-4
    Cat.:
    P0582Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human AQP-4
    Cat.:
    P0582Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human AQP-4
    Polyclonal Antibody for Human AQP-4
    Cat.:
    P0582Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human AQP-4
    Monoclonal Antibody for Human AQP-4
    Monoclonal Antibody for Human AQP-4
    Monoclonal Antibody for Human AQP-4
    Protein for Human AQP-4
    Protein for Human AQP-4
    Protein for Human AQP-4
    Protein for Human AQP-4

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "cDNA cloning, gene organization, and chromosomal localization of a human mercurial insensitive water channel. Evidence for distinct transcriptional units."
      Yang B. , Ma T. , Verkman A.S.
      J. Biol. Chem.270:22907-22913(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Fetal brain.
    2. 2.
      "A water channel closely related to rat brain aquaporin 4 is expressed in acid- and pepsinogen-secretory cells of human stomach."
      Misaka T. , Abe K. , Iwabuchi K. , Kusakabe Y. , Ichinose M. , Miki K. , Emori Y. , Arai S.
      FEBS Lett.381:208-212(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brain."
      Lu M. , Lee M.D. , Smith B.L. , Jung J.S. , Agre P. , Verdijk M.A.J. , Merkx G. , Rijss J.P.L. , Deen P.M.T.
      Proc. Natl. Acad. Sci. U.S.A.93:10908-10912(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Lung.
    5. 6.
      "Megalencephalic leukoencephalopathy with subcortical cysts protein 1 functionally cooperates with the TRPV4 cation channel to activate the response of astrocytes to osmotic stress: dysregulation by pathological mutations."
      Lanciotti A. , Brignone M.S. , Molinari P. , Visentin S. , De Nuccio C. , Macchia G. , Aiello C. , Bertini E. , Aloisi F. , Petrucci T.C. , Ambrosini E.
      Hum. Mol. Genet.21:2166-2180(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
    6. 7.
      "Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance."
      Ho J.D. , Yeh R. , Sandstrom A. , Chorny I. , Harries W.E. , Robbins R.A. , Miercke L.J. , Stroud R.M.
      Proc. Natl. Acad. Sci. U.S.A.106:7437-7442(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 32-254;SUBUNIT
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