Protein name:
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAM-TS 4;ADAM-TS4;ADAMTS-4) ;
Alternative:
Aggrecanase-1 ;ADMP-1 ;
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Interacts with SRPX2.
Function:
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
Subcellular Location:
Secreted
extracellular space
extracellular matrix
Protein Attributes:
50:
MSHMDSHPGR | GLADGWLWGI | QPRLLLPTVP | VSGSRLVWLL | LLASLLPSAW |
100:
PASPLPREEE | IVFPEKLNGS | VLPGLGAPAR | LLYRLPAFGE | TLLLELEKDP |
150:
GVQVEGLTVQ | YLGRAPELLG | GAEPGTYLTG | TINGDPESVA | SLHWDGGALL |
200:
GVLQYRGTEL | HIQPLEGGAP | NSAGGPGAHI | LRRKSPVSGQ | GPMCNVKAPP |
250:
GKPSPSPRRA | KRFASLSRFV | ETLVVADDKM | AAFHGAGLKR | YLLTVMAAAA |
300:
KAFKHPSIRN | PVSLVVTRLV | VLGPGEEGPQ | VGPSAAQTLR | SFCAWQRGLN |
350:
TPDDADPGHF | DTAILFTRQD | LCGVSTCDTL | GMADVGTVCD | PARSCAIVED |
400:
DGLQSAFTAA | HELGHVFSML | HDNSKQCTGL | NGPESTSRHV | MAPVMAHVDP |
450:
EEPWSPCSAR | FITDFLDNGF | GHCLLDKPEA | PLHLPVTFPG | KDYDADRQCQ |
500:
LTFGPDSRHC | PQLPPPCAAL | WCSGHLNGHA | MCQTKHSPWA | DGTPCGPAQA |
550:
CMGGRCLHVD | QLQAFNVPQA | GGWGPWGSWG | DCSRSCGGGV | QFSSRDCTRP |
600:
VPRNGGKYCE | GRRTRFRSCN | TQDCPTGSAL | TFREEQCAAY | NHRTDLFKNF |
650:
PGPMDWVPRY | TGVAPRDQCK | LTCQTRALGY | YYVLDPRVAD | GTPCSPDSSS |
700:
VCVQGRCIHA | GCDRVIGSKK | KFDKCMVCGG | DGSSCSKQSG | SFKKFRYGYN |
750:
NVVTIPAGAT | HILVRQQGSP | SVRSLYLALK | LPDGSYALNG | EYTLIPSPTD |
800:
VVLPGAVSLR | YSGATAASET | LSGHGPLAEP | LTLQVLVAGN | PQNARLRYSF |
839:
FVPRPRPVPS | TPRPTPQDWL | RRKSQILEIL | RRRSWAGRK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Bovine
Mouse
ELISA Kit for Bovine ADAM-TS 4
ELISA Kit for Bovine ADAM-TS 4
ELISA Kit for Bovine ADAM-TS 4
ELISA Kit for Bovine ADAM-TS 4
CLIA Kit for Bovine ADAM-TS 4
CLIA Kit for Bovine ADAM-TS 4
CLIA Kit for Bovine ADAM-TS 4
CLIA Kit for Bovine ADAM-TS 4
Polyclonal Antibody for Bovine ADAM-TS 4
Polyclonal Antibody for Bovine ADAM-TS 4
Polyclonal Antibody for Bovine ADAM-TS 4
Polyclonal Antibody for Bovine ADAM-TS 4
Monoclonal Antibody for Bovine ADAM-TS 4
Monoclonal Antibody for Bovine ADAM-TS 4
Monoclonal Antibody for Bovine ADAM-TS 4
Monoclonal Antibody for Bovine ADAM-TS 4
Protein for Bovine ADAM-TS 4
Protein for Bovine ADAM-TS 4
Protein for Bovine ADAM-TS 4
Protein for Bovine ADAM-TS 4
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Hereford .
tissue :
Thalamus .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 332-531
tissue :
Cartilage .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 332-531
tissue :
Cartilage chondrocyte .
5.
"Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins."
Tortorella M.D.
,
Burn T.C.
,
Pratta M.A.
,
Abbaszade I.
,
Hollis J.M.
,
Liu R.-Q.
,
Rosenfeld S.A.
,
Copeland R.A.
,
Decicco C.P.
,
Wynn R.
,
Rockwell A.
,
Yang F.
,
Duke J.L.
,
Solomon K.
,
George H.
,
Bruckner R.
,
Nagase H.
,
Itoh Y.
,
Ellis D.M.
,
Ross H.
,
Wiswall B.H.
,
Murphy K.
,
Hillman M.C. Jr.
,
Hollis G.F.
,
Newton R.C.
,
Magolda R.L.
,
Trzaskos J.M.
,
Arner E.C.
more...
Science284:1664-1666(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 213-239; 610-615 AND 626-637
tissue :
Cartilage .