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Index > Protein center > Gm6484(Gene name) > Mouse
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  • Gm6484 (Gene name),
  • Betatrophin (Protein name ),  BETAT_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Gm6484(Angptl8;Rifl);
    Protein name:
    Betatrophin;
    Alternative:
    Refeeding-induced fat and liver protein;Angiopoietin-like protein 8;Lipasin;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with ANGPTL3.
    Function:
    Hormone that specifically promotes pancreatic beta cell proliferation and beta cell mass expansion, thereby improving glucose tolerance. Promotes pancreatic beta cell proliferation without insulin resistance. Also acts as a blood lipid regulator by regulating serum triglyceride levels; possibly by promoting ANGPTL3 cleavage.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    198
    Sequence:
    50:
    MAVLALCLLW | TLASAVRPAP | VAPLGGPEPA | QYEELTLLFH | GALQLGQALN | 
    100:
    GVYRATEARL | TEAGHSLGLY | DRALEFLGTE | VRQGQDATQE | LRTSLSEIQV | 
    150:
    EEDALHLRAE | ATARSLGEVA | RAQQALRDTV | RRLQVQLRGA | WLGQAHQEFE | 
    198:
    TLKARADKQS | HLLWALTGHV | QRQQREMAEQ | QQWLRQIQQR | LHTAALPA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Betatrophin
    Cat.:
    E11644m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Betatrophin
    Cat.:
    U11644m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Mouse Betatrophin
    Cat.:
    P11644Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Betatrophin
    Protein for Mouse Betatrophin

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-181
      strain: FVB/N.
      tissue: Liver.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
    4. 4.
      "Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism."
      Ren G. , Kim J.Y. , Smas C.M.
      Am. J. Physiol.303:E334-E351(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
    5. 5.
      "Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels."
      Zhang R.
      Biochem. Biophys. Res. Commun.424:786-792(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;INDUCTION
    6. 6.
      "Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family."
      Fu Z. , Yao F. , Abou-Samra A.B. , Zhang R.
      Biochem. Biophys. Res. Commun.430:1126-1131(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
    8. 8.
      "Betatrophin: a hormone that controls pancreatic beta cell proliferation."
      Yi P. , Park J.S. , Melton D.A.
      Cell153:747-758(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    9. 9.
      "Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis."
      Wang Y. , Quagliarini F. , Gusarova V. , Gromada J. , Valenzuela D.M. , Cohen J.C. , Hobbs H.H.
      Proc. Natl. Acad. Sci. U.S.A.110:16109-16114(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    10. 10.
      "Elevated mouse hepatic betatrophin expression does not increase human beta-cell replication in the transplant setting."
      Jiao Y. , Le Lay J. , Yu M. , Naji A. , Kaestner K.H.
      Diabetes63:1283-1288(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: EXPRESSION IN HUMAN PANCREATIC BETA-CELLS
    11. 11.
      "Perspectives on the activities of ANGPTL8/betatrophin."
      Yi P. , Park J.S. , Melton D.A.
      Cell159:467-468(2014)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ROLE IN PANCREATIC BETA-CELLS PROLIFERATION
    12. 12.
      "ANGPTL8/betatrophin does not control pancreatic beta cell expansion."
      Gusarova V. , Alexa C.A. , Na A. , Stevis P.E. , Xin Y. , Bonner-Weir S. , Cohen J.C. , Hobbs H.H. , Murphy A.J. , Yancopoulos G.D. , Gromada J.
      Cell159:691-696(2014)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
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