Protein name:
Cathepsin D ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Consists of a light chain and a heavy chain.
Function:
Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
Subcellular Location:
Lysosome
Melanosome
Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Protein Attributes:
50:
MQPSSLLPLA | LCLLAAPASA | LVRIPLHKFT | SIRRTMSEVG | GSVEDLIAKG |
100:
PVSKYSQAVP | AVTEGPIPEV | LKNYMDAQYY | GEIGIGTPPQ | CFTVVFDTGS |
150:
SNLWVPSIHC | KLLDIACWIH | HKYNSDKSST | YVKNGTSFDI | HYGSGSLSGY |
200:
LSQDTVSVPC | QSASSASALG | GVKVERQVFG | EATKQPGITF | IAAKFDGILG |
250:
MAYPRISVNN | VLPVFDNLMQ | QKLVDQNIFS | FYLSRDPDAQ | PGGELMLGGT |
300:
DSKYYKGSLS | YLNVTRKAYW | QVHLDQVEVA | SGLTLCKEGC | EAIVDTGTSL |
350:
MVGPVDEVRE | LQKAIGAVPL | IQGEYMIPCE | KVSTLPAITL | KLGGKGYKLS |
400:
PEDYTLKVSQ | AGKTLCLSGF | MGMDIPPPSG | PLWILGDVFI | GRYYTVFDRD |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Chicken
Pig
Bovine
Dog
Rat
ELISA Kit for Human Cathepsin D
ELISA Kit for Human Cathepsin D
ELISA Kit for Human Cathepsin D
ELISA Kit for Human Cathepsin D
ELISA Kit for Human Cathepsin D
ELISA Kit for Human Cathepsin D
ELISA Kit for Human Cathepsin D
CLIA Kit for Human Cathepsin D
CLIA Kit for Human Cathepsin D
CLIA Kit for Human Cathepsin D
CLIA Kit for Human Cathepsin D
CLIA Kit for Human Cathepsin D
CLIA Kit for Human Cathepsin D
CLIA Kit for Human Cathepsin D
Polyclonal Antibody for Human Cathepsin D
Polyclonal Antibody for Human Cathepsin D
Polyclonal Antibody for Human Cathepsin D
Polyclonal Antibody for Human Cathepsin D
Polyclonal Antibody for Human Cathepsin D
Polyclonal Antibody for Human Cathepsin D
Polyclonal Antibody for Human Cathepsin D
Monoclonal Antibody for Human Cathepsin D
Monoclonal Antibody for Human Cathepsin D
Monoclonal Antibody for Human Cathepsin D
Monoclonal Antibody for Human Cathepsin D
Monoclonal Antibody for Human Cathepsin D
Monoclonal Antibody for Human Cathepsin D
Monoclonal Antibody for Human Cathepsin D
Protein for Human Cathepsin D
Protein for Human Cathepsin D
Protein for Human Cathepsin D
Protein for Human Cathepsin D
Protein for Human Cathepsin D
Protein for Human Cathepsin D
Protein for Human Cathepsin D
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
Zhu J, Li C, Dai Y, et al.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N.
,
Chen X.
,
Rolfs A.
,
Halleck A.
,
Hines L.
,
Eisenstein S.
,
Koundinya M.
,
Raphael J.
,
Moreira D.
,
Kelley T.
,
LaBaer J.
,
Lin Y.
,
Phelan M.
,
Farmer A.
Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Kidney .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22
9.
Hochstrasser D.F.
,
Frutiger S.
,
Paquet N.
,
Bairoch A.
,
Ravier F.
,
Pasquali C.
,
Sanchez J.-C.
,
Tissot J.-D.
,
Bjellqvist B.
,
Vargas R.
,
Appel R.D.
,
Hughes G.J.
Submitted (1992-06) to the UniProtKB
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 170-180
tissue :
Liver .
10.
"Proteomic analysis of early melanosomes: identification of novel melanosomal proteins."
Basrur V.
,
Yang F.
,
Kushimoto T.
,
Higashimoto Y.
,
Yasumoto K.
,
Valencia J.
,
Muller J.
,
Vieira W.D.
,
Watabe H.
,
Shabanowitz J.
,
Hearing V.J.
,
Hunt D.F.
,
Appella E.
J. Proteome Res.2:69-79(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
tissue :
Melanoma .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION AT ASN-263
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-263
tissue :
Plasma .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN CLN10;VARIANT ARG-282
14.
"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."
Chi A.
,
Valencia J.C.
,
Hu Z.-Z.
,
Watabe H.
,
Yamaguchi H.
,
Mangini N.J.
,
Huang H.
,
Canfield V.A.
,
Cheng K.C.
,
Yang F.
,
Abe R.
,
Yamagishi S.
,
Shabanowitz J.
,
Hearing V.J.
,
Wu C.
,
Appella E.
,
Hunt D.F.
J. Proteome Res.5:3135-3144(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
tissue :
Melanoma .
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-263
tissue :
Platelet .
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-134 AND ASN-263
tissue :
Liver .
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;SUBCELLULAR LOCATION
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION AT THR-63;IDENTIFICATION BY MASS SPECTROMETRY
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (3 ANGSTROMS)
tissue :
Spleen .
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS)
tissue :
Liver .
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT VAL-58
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS CLN10 ILE-229 AND CYS-383
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT CLN10 ILE-229