Gene name:
Cdkn2a (P16ink4a) ;
Protein name:
Cyclin-dependent kinase inhibitor 2A, isoform 1 ;
Alternative:
p16-INK4a (p16;p16-INK4) ;Cyclin-dependent kinase 4 inhibitor A (CDK4I) ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Heterodimer with CDK4 or CDK6. Predominamt P16 complexes contained CDK6. Interacts with CDK4 (both 'T-172'-phosphorylated and non-phosphorylated forms); the interaction inhibits cyclin D-CDK4 kinase activity. Interacts with ISCO2.
Function:
Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
Subcellular Location:
Cytoplasm
Nucleus
Protein Attributes:
50:
MESSADRLAR | AAALGREHEV | RALLEAGASP | NAPNTFGRTP | IQVMMMGNVK |
100:
VAALLLSYGA | DSNCEDPTTL | SRPVHDAARE | GFLDTLVVLH | QAGARLDVRD |
150:
AWGRLPLDLA | LERGHHDVVR | YLRYLLSSAG | NVSRVTDRHN | FCSSTPRCLG |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Rat Cyclin-dependent kinase inhibitor 2A, isoform 1
ELISA Kit for Rat Cyclin-dependent kinase inhibitor 2A, isoform 1
ELISA Kit for Rat Cyclin-dependent kinase inhibitor 2A, isoform 1
CLIA Kit for Rat Cyclin-dependent kinase inhibitor 2A, isoform 1
CLIA Kit for Rat Cyclin-dependent kinase inhibitor 2A, isoform 1
CLIA Kit for Rat Cyclin-dependent kinase inhibitor 2A, isoform 1
Polyclonal Antibody for Rat Cyclin-dependent kinase inhibitor 2A, isoform 1
Polyclonal Antibody for Rat Cyclin-dependent kinase inhibitor 2A, isoform 1
Polyclonal Antibody for Rat Cyclin-dependent kinase inhibitor 2A, isoform 1
Monoclonal Antibody for Rat Cyclin-dependent kinase inhibitor 2A, isoform 1
Monoclonal Antibody for Rat Cyclin-dependent kinase inhibitor 2A, isoform 1
Monoclonal Antibody for Rat Cyclin-dependent kinase inhibitor 2A, isoform 1
Protein for Rat Cyclin-dependent kinase inhibitor 2A, isoform 1
Protein for Rat Cyclin-dependent kinase inhibitor 2A, isoform 1
Protein for Rat Cyclin-dependent kinase inhibitor 2A, isoform 1
R&D Technical Data
12% SDS-PAGE Analysis
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
strain :
Fischer 344/N .
tissue :
Lung .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
ACI/SegHsd .
strain :
Brown Norway/SsNHsd .
strain :
COP .
tissue :
Spleen .