Gene name:
CD40LG (CD40L;TNFSF5;TRAP) ;
Protein name:
CD40 ligand (CD40-L) ;
Alternative:
TNF-related activation protein (TRAP) ;T-cell antigen Gp39 ;Tumor necrosis factor ligand superfamily member 5 ;
CD:
CD154 ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.
Subcellular Location:
CD40 ligand, soluble form
Secreted
Protein Attributes:
50:
MIETYNQTSP | RSAATGLPIS | MKIFMYLLTV | FLITQMIGSA | LFAVYLHRRL |
100:
DKIEDERNLH | EDFVFMKTIQ | RCNTGERSLS | LLNCEEIKSQ | FEGFVKDIML |
150:
NKEETKKENS | FEMQKGDQNP | QIAAHVISEA | SSKTTSVLQW | AEKGYYTMSN |
200:
NLVTLENGKQ | LTVKRQGLYY | IYAQVTFCSN | REASSQAPFI | ASLCLKSPGR |
250:
FERILLRAAN | THSSAKPCGQ | QSIHLGGVFE | LQPGASVFVN | VTDPSQVSHG |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Bovine
Chicken
Pig
Human
Dog
ELISA Kit for Human CD40-L
ELISA Kit for Human CD40-L
ELISA Kit for Human CD40-L
ELISA Kit for Human CD40-L
ELISA Kit for Human CD40-L
ELISA Kit for Human CD40-L
ELISA Kit for Human CD40-L
CLIA Kit for Human CD40-L
CLIA Kit for Human CD40-L
CLIA Kit for Human CD40-L
CLIA Kit for Human CD40-L
CLIA Kit for Human CD40-L
CLIA Kit for Human CD40-L
CLIA Kit for Human CD40-L
Polyclonal Antibody for Human CD40-L
Polyclonal Antibody for Human CD40-L
Polyclonal Antibody for Human CD40-L
Polyclonal Antibody for Human CD40-L
Polyclonal Antibody for Human CD40-L
Polyclonal Antibody for Human CD40-L
Polyclonal Antibody for Human CD40-L
Monoclonal Antibody for Human CD40-L
Monoclonal Antibody for Human CD40-L
Monoclonal Antibody for Human CD40-L
Monoclonal Antibody for Human CD40-L
Monoclonal Antibody for Human CD40-L
Monoclonal Antibody for Human CD40-L
Monoclonal Antibody for Human CD40-L
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
"The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity."
Hollenbaugh D.
,
Grosmaire L.S.
,
Kullas C.D.
,
Chalupny J.N.
,
Braesch-Andersen S.
,
Noelle R.J.
,
Stamenkovic I.
,
Ledbetter J.A.
,
Aruffo A.
EMBO J.11:4313-4321(1992)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
"The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome."
Aruffo A.
,
Farrington M.
,
Hollenbaugh D.
,
Li X.
,
Milatovich A.
,
Nonoyama S.
,
Bajorath J.
,
Grosmaire L.S.
,
Stenkamp R.
,
Neubauer M.
,
Roberts R.L.
,
Noelle R.J.
,
Ledbetter J.A.
,
Francke U.
,
Ochs H.D.
Cell72:291-300(1993)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];VARIANTS HIGM1 128-ARG-GLY-129 AND PRO-235
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Blood .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 113-117;PROTEOLYTIC PROCESSING
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE OF CARBOHYDRATE ON ASN-240;IDENTIFICATION BY MASS SPECTROMETRY
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 116-261
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : 3D-STRUCTURE MODELING OF COMPLEX WITH CD40
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS HIGM1 ARG-36 AND GLY-140
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT HIGM1 GLU-123
15.
"CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome."
Allen R.C.
,
Armitage R.J.
,
Conley M.E.
,
Rosenblatt H.
,
Jenkins N.A.
,
Copeland N.G.
,
Bedell M.A.
,
Edelhoff S.
,
Disteche C.M.
,
Simoneaux D.K.
,
Fanslow W.C.
,
Belmont J.W.
,
Spriggs M.K.
Science259:990-993(1993)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS HIGM1 PRO-155; ASN-211 AND VAL-227
16.
"Characterization of nine novel mutations in the CD40 ligand gene in patients with X-linked hyper IgM syndrome of various ancestry."
Macchi P.
,
Villa A.
,
Strina D.
,
Sacco M.G.
,
Morali F.
,
Brugnoni D.
,
Giliani S.
,
Mantuano E.
,
Fasth A.
,
Andersson B.
,
Zegers B.J.M.
,
Cavagni G.
,
Reznick I.
,
Levy J.
,
Zan-Bar I.
,
Porat Y.
,
Airo P.
,
Plebani A.
,
Vezzoni P.
,
Notarangelo L.D.
more...
Am. J. Hum. Genet.56:898-906(1995)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS HIGM1 ALA-126; ARG-140 AND GLU-144
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT HIGM1 GLU-237
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS HIGM1 ARG-38; ARG-125; ARG-174 AND SER-257
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS HIGM1 PRO-155 AND VAL-227;VARIANT ARG-219
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS HIGM1 ARG-36; CYS-140; GLY-227 DEL; SER-231 AND MET-254
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS HIGM1 SER-116; ASN-147; CYS-170; VAL-227; SER-231; PRO-235; MET-254 AND SER-258