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Index > Protein center > ANGPT2(Gene name) > Human
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  • ANGPT2 (Gene name),
  • Angiopoietin-2 (Protein name ),  ANGP2_HUMAN from NCBI database.
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  • General Annotation
  • |
  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
  • |
  • Vaild Sequence
  • |
  • Related Databases
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  • Citations  (1)
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  • Gene name:
    ANGPT2;
    Protein name:
    Angiopoietin-2(ANG-2);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Can induce tyrosine phosphorylation of TIE2. Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. Its function may be context-dependent. In the absence of angiogenic inducers, such as VEGF, ANG2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    496
    Sequence:
    50:
    MWQIVFFTLS | CDLVLAAAYN | NFRKSMDSIG | KKQYQVQHGS | CSYTFLLPEM | 
    100:
    DNCRSSSSPY | VSNAVQRDAP | LEYDDSVQRL | QVLENIMENN | TQWLMKLENY | 
    150:
    IQDNMKKEMV | EIQQNAVQNQ | TAVMIEIGTN | LLNQTAEQTR | KLTDVEAQVL | 
    200:
    NQTTRLELQL | LEHSLSTNKL | EKQILDQTSE | INKLQDKNSF | LEKKVLAMED | 
    250:
    KHIIQLQSIK | EEKDQLQVLV | SKQNSIIEEL | EKKIVTATVN | NSVLQKQQHD | 
    300:
    LMETVNNLLT | MMSTSNSAKD | PTVAKEEQIS | FRDCAEVFKS | GHTTNGIYTL | 
    350:
    TFPNSTEEIK | AYCDMEAGGG | GWTIIQRRED | GSVDFQRTWK | EYKVGFGNPS | 
    400:
    GEYWLGNEFV | SQLTNQQRYV | LKIHLKDWEG | NEAYSLYEHF | YLSSEELNYR | 
    450:
    IHLKGLTGTA | GKISSISQPG | NDFSTKDGDN | DKCICKCSQM | LTGGWWFDAC | 
    496:
    GPSNLNGMYY | PQRQNTNKFN | GIKWYYWKGS | GYSLKATTMM | IRPADF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    MIM:
    Pfam:
    SMR:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human ANG-2
    Cat.:
    E0009h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human ANG-2
    Cat.:
    E0009m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human ANG-2
    Cat.:
    E0009r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human ANG-2
    Cat.:
    E0009p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human ANG-2
    Cat.:
    E0009b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human ANG-2
    Cat.:
    E0009d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human ANG-2
    Cat.:
    U0009r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human ANG-2
    Cat.:
    U0009p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human ANG-2
    Cat.:
    U0009m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human ANG-2
    Cat.:
    U0009h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human ANG-2
    Cat.:
    U0009b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human ANG-2
    Cat.:
    U0009d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human ANG-2
    Polyclonal Antibody for Human ANG-2
    Cat.:
    P0009Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human ANG-2
    Cat.:
    P0009Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human ANG-2
    Polyclonal Antibody for Human ANG-2
    Polyclonal Antibody for Human ANG-2
    Cat.:
    P0009Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human ANG-2
    Monoclonal Antibody for Human ANG-2
    Monoclonal Antibody for Human ANG-2
    Monoclonal Antibody for Human ANG-2
    Monoclonal Antibody for Human ANG-2
    Monoclonal Antibody for Human ANG-2
    Protein for Human ANG-2
    Protein for Human ANG-2
    Protein for Human ANG-2
    Protein for Human ANG-2
    Protein for Human ANG-2
    Protein for Human ANG-2

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    Citations
    [1].
    Yesildal F, Koc E, Tas A, et al.
    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH TEK/TIE2;FUNCTION
      tissue: Lung.
    2. 2.
      "Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma."
      Tanaka S. , Mori M. , Sakamoto Y. , Makuuchi M. , Sugimachi K. , Wands J.R.
      J. Clin. Invest.103:341-345(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    3. 3.
      "Characterization and expression of a novel alternatively spliced human angiopoietin-2."
      Kim I. , Kim J.-H. , Ryu Y.S. , Jung S.H. , Nah J.J. , Koh G.Y.
      J. Biol. Chem.275:18550-18556(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
      tissue: Umbilical vein endothelial cell.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Substantia nigra.
    5. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Colon.
    7. 8.
      "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats."
      Fiedler U. , Krissl T. , Koidl S. , Weiss C. , Koblizek T. , Deutsch U. , Martiny-Baron G. , Marme D. , Augustin H.G.
      J. Biol. Chem.278:1721-1727(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TEK/TIE2
    8. 9.
      "Biological characterization of angiopoietin-3 and angiopoietin-4."
      Lee H.J. , Cho C.H. , Hwang S.J. , Choi H.H. , Kim K.T. , Ahn S.Y. , Kim J.H. , Oh J.L. , Lee G.M. , Koh G.Y.
      FASEB J.18:1200-1208(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN REGULATION OF ANGIOGENESIS; CELL SURVIVAL; CELL MIGRATION AND ACTIVATION OF AKT1;INTERACTION WITH TEK/TIE2
    9. 10.
      "Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells."
      Yacyshyn O.K. , Lai P.F.H. , Forse K. , Teichert-Kuliszewska K. , Jurasz P. , Stewart D.J.
      Angiogenesis12:25-33(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 11.
      "Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium."
      Yuan H.T. , Khankin E.V. , Karumanchi S.A. , Parikh S.M.
      Mol. Cell. Biol.29:2011-2022(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TEK/TIE2
    11. 12.
      "Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system."
      Augustin H.G. , Koh G.Y. , Thurston G. , Alitalo K.
      Nat. Rev. Mol. Cell Biol.10:165-177(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    12. 13.
      "Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition."
      Barton W.A. , Tzvetkova D. , Nikolov D.B.
      Structure13:825-832(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 281-496;DISULFIDE BONDS;CALCIUM-BINDING SITES
    13. 14.
      "Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex."
      Barton W.A. , Tzvetkova-Robev D. , Miranda E.P. , Kolev M.V. , Rajashankar K.R. , Himanen J.P. , Nikolov D.B.
      Nat. Struct. Mol. Biol.13:524-532(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.7 ANGSTROMS) OF 281-495 IN COMPLEX WITH TEK;DISULFIDE BONDS;CALCIUM-BINDING SITES
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