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Index > Protein center > CTGF(Gene name) > Human
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  • CTGF (Gene name),
  • Connective tissue growth factor (Protein name ),  CTGF_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (1)
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  • Gene name:
    CTGF(CCN2;HCS24;IGFBP8);
    Protein name:
    Connective tissue growth factor;
    Alternative:
    Hypertrophic chondrocyte-specific protein 24;CCN family member 2;Insulin-like growth factor-binding protein 8(IBP-8;IGF-binding protein 8;IGFBP-8);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer.
    Function:
    Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.
    Subcellular Location:
    Secreted extracellular space extracellular matrix Secreted
    Protein Attributes:
    Sequence length:
    349
    Sequence:
    50:
    MTAASMGPVR | VAFVVLLALC | SRPAVGQNCS | GPCRCPDEPA | PRCPAGVSLV | 
    100:
    LDGCGCCRVC | AKQLGELCTE | RDPCDPHKGL | FCHFGSPANR | KIGVCTAKDG | 
    150:
    APCIFGGTVY | RSGESFQSSC | KYQCTCLDGA | VGCMPLCSMD | VRLPSPDCPF | 
    200:
    PRRVKLPGKC | CEEWVCDEPK | DQTVVGPALA | AYRLEDTFGP | DPTMIRANCL | 
    250:
    VQTTEWSACS | KTCGMGISTR | VTNDNASCRL | EKQSRLCMVR | PCEADLEENI | 
    300:
    KKGKKCIRTP | KISKPIKFEL | SGCTSMKTYR | AKFCGVCTDG | RCCTPHRTTT | 
    349:
    LPVEFKCPDG | EVMKKNMMFI | KTCACHYNCP | GDNDIFESLY | YRKMYGDMA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    String:
    UniGene:
    KEGG:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Connective tissue growth factor
    Cat.:
    E0010h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Connective tissue growth factor
    Cat.:
    E0010m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Connective tissue growth factor
    Cat.:
    E0010r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Connective tissue growth factor
    Cat.:
    E0010b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Connective tissue growth factor
    Cat.:
    E0010p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Connective tissue growth factor
    Cat.:
    U0010h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Connective tissue growth factor
    Cat.:
    U0010r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Connective tissue growth factor
    Cat.:
    U0010m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Connective tissue growth factor
    Cat.:
    U0010p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Connective tissue growth factor
    Cat.:
    U0010b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Connective tissue growth factor
    Polyclonal Antibody for Human Connective tissue growth factor
    Polyclonal Antibody for Human Connective tissue growth factor
    Cat.:
    P0010Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Connective tissue growth factor
    Cat.:
    P0010Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Connective tissue growth factor
    Cat.:
    P0010Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Connective tissue growth factor
    Monoclonal Antibody for Human Connective tissue growth factor
    Monoclonal Antibody for Human Connective tissue growth factor
    Monoclonal Antibody for Human Connective tissue growth factor
    Monoclonal Antibody for Human Connective tissue growth factor
    Protein for Human Connective tissue growth factor
    Protein for Human Connective tissue growth factor
    Protein for Human Connective tissue growth factor
    Cat.:
    R0010h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human Connective tissue growth factor
    Protein for Human Connective tissue growth factor

    R&D Technical Data

    s

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    Precision

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤4.0%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.8%

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    Recovery

    Recovery was determined by spiking various levels of CTGF into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    99

    95-103

    Plasma

    98

    96-101

     

     

     

     

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    Linearity

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of CTGF and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    98-105%

    100-106%

    92-98%

    92-103%

    EDTA plasma(n=5)

    89-98%

    93-100%

    95-102%

    96-103%

    heparin plasma(n=5)

    99-104%

     

    96-105%

    101-108%

    92-99%

     

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    References
    1. 1.
      "Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10."
      Bradham D.M. , Igarashi A. , Potter R.L. , Grotendorst G.R.
      J. Cell Biol.114:1285-1294(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ASP-83
      tissue: Umbilical vein endothelial cell.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ASP-83
      tissue: Umbilical vein endothelial cell.
    3. 3.
      "Human connective tissue growth factor is expressed in advanced atherosclerotic lesions."
      Oemar B.S. , Werner A. , Garnier J.-M. , Do D.D. , Godoy N. , Nauck M. , Marz W. , Rupp J. , Pech M. , Luescher T.F.
      Circulation95:831-839(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ASP-83
      tissue: Aorta.
    4. 4.
      "Expression, purification and bio-activity of human connective tissue growth factor."
      Li Q.-H. , Wang L.-C. , Liu L.-D. , Dong S.-Z. , Wang J.-J. , Hu F. , Wang J. , He S.-Q. , Dong C.-H. , Zhao S.-D. , Zhao H.-L.
      Submitted (2003-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ASP-83
    5. 5.
      "Complete mRNA sequence of human connective tissue growth factor."
      Dai W.-J. , Jiang H.-C. , Fu S.-B.
      Submitted (2004-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ASP-83
      tissue: Liver.
    6. 6.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ASP-83
    7. 7.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ASP-83
    8. 8.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "Differential expression of novH and CTGF in human glioma cell lines."
      Xin L.W. , Martinerie C. , Zumkeller W. , Westphal M. , Perbal B.
      Clin. Mol. Pathol.49:91-97(1996)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20
      tissue: Placenta.
    11. 11.
      "Identification of human CCN2 (connective tissue growth factor) promoter polymorphisms."
      Blom I.E. , van Dijk A.J. , de Weger R.A. , Tilanus M.G.J. , Goldschmeding R.
      J. Clin. Pathol.54:192-196(2001)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20
    12. 12.
      "Connective tissue growth factor mRNA is expressed in human keratinocytes as an immediate early gene that responds to serum, EGF, or wounding."
      Cody C.W. , Walker N.J. , Greenlee W.F. , Sutter T.R.
      Submitted (1994-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 75-349;VARIANT ASP-83
    13. 13.
      "Expression of a gene encoding a novel potential IGF binding protein in human tissues."
      Martinerie C. , Perbal B.
      C. R. Acad. Sci. III, Sci. Vie313:345-351(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 99-176 AND 204-225 (ISOFORM 1);TISSUE SPECIFICITY
    14. 14.
      "Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture."
      Nakanishi T. , Nishida T. , Shimo T. , Kobayashi K. , Kubo T. , Tamatani T. , Tezuka K. , Takigawa M.
      Endocrinology141:264-273(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
      tissue: Chondrocyte.
    15. 15.
      "The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion."
      Ball D.K. , Rachfal A.W. , Kemper S.A. , Brigstock D.R.
      J. Endocrinol.176:R1-R7(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HEPARIN-BINDING;FUNCTION IN CELL ADHESION
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