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Index > Protein center > EFNA2(Gene name) > Human
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  • EFNA2 (Gene name),
  • Ephrin-A2 (Protein name ),  EFNA2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    EFNA2(EPLG6;LERK6);
    Protein name:
    Ephrin-A2;
    Alternative:
    HEK7 ligand(HEK7-L);EPH-related receptor tyrosine kinase ligand 6(LERK-6);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds to the receptor tyrosine kinases EPHA3, EPHA4 and EPHA5. Interacts with EPHA8; activates EPHA8.
    Function:
    Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.
    Subcellular Location:
    Cell membrane Lipid-anchor GPI-anchor
    Protein Attributes:
    Sequence length:
    213
    Sequence:
    50:
    MAPAQRPLLP | LLLLLLPLPP | PPFARAEDAA | RANSDRYAVY | WNRSNPRFHA | 
    100:
    GAGDDGGGYT | VEVSINDYLD | IYCPHYGAPL | PPAERMEHYV | LYMVNGEGHA | 
    150:
    SCDHRQRGFK | RWECNRPAAP | GGPLKFSEKF | QLFTPFSLGF | EFRPGHEYYY | 
    200:
    ISATPPNAVD | RPCLRLKVYV | RPTNETLYEA | PEPIFTSNNS | CSSPGGCRLF | 
    213:
    LSTIPVLWTL | LGS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    Pfam:
    SMR:
    MIM:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Ephrin-A2
    Cat.:
    E0301m
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Ephrin-A2
    Cat.:
    E0301h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Ephrin-A2
    Cat.:
    E0301c
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Ephrin-A2
    Cat.:
    U0301h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Ephrin-A2
    Cat.:
    U0301m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Ephrin-A2
    Cat.:
    U0301c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Ephrin-A2
    Cat.:
    P0301Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Ephrin-A2
    Cat.:
    P0301Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Ephrin-A2
    Monoclonal Antibody for Human Ephrin-A2
    Monoclonal Antibody for Human Ephrin-A2
    Monoclonal Antibody for Human Ephrin-A2
    Protein for Human Ephrin-A2
    Protein for Human Ephrin-A2
    Protein for Human Ephrin-A2

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    References
    1. 1.
      "Characterization of the genes for mouse LERK-3/Ephrin-A3 (Epl3), mouse LERK-4/Ephrin-A4 (Epl4), and human LERK-6/Ephrin-A2 (EPLG6): conservation of intron/exon structure."
      Cerretti D.P. , Nelson N.
      Genomics47:131-135(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "Cloning, chromosomal mapping, and tissue expression of the gene encoding the human Eph-family kinase ligand ephrin-A2."
      Aasheim H.-C. , Pedeutour F. , Grosgeorge J. , Logtenberg T.
      Biochem. Biophys. Res. Commun.252:378-382(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Brain.
    3. 3.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "Structural plasticity of EPH receptor A4 facilitates cross-class ephrin signaling."
      Bowden T.A. , Aricescu A.R. , Nettleship J.E. , Siebold C. , Rahman-Huq N. , Owens R.J. , Stuart D.I. , Jones E.Y.
      Structure17:1386-1397(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 33-177 IN COMPLEX WITH EPHA4;DISULFIDE BONDS;SUBUNIT
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