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Index > Protein center > Fgf1(Gene name) > Mouse
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  • Fgf1 (Gene name),
  • Heparin-binding growth factor 1 (Protein name ),  FGF1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Fgf1(Fgf-1;Fgfa);
    Protein name:
    Heparin-binding growth factor 1(HBGF-1);
    Alternative:
    Heparin-binding growth factor 1(HBGF-1);Acidic fibroblast growth factor(aFGF);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13.
    Function:
    Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.
    Subcellular Location:
    Secreted Cytoplasm Cytoplasm cell cortex Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1.
    Protein Attributes:
    Sequence length:
    155
    Sequence:
    50:
    MAEGEITTFA | ALTERFNLPL | GNYKKPKLLY | CSNGGHFLRI | LPDGTVDGTR | 
    100:
    DRSDQHIQLQ | LSAESAGEVY | IKGTETGQYL | AMDTEGLLYG | SQTPNEECLF | 
    150:
    LERLEENHYN | TYTSKKHAEK | NWFVGLKKNG | SCKRGPRTHY | GQKAILFLPL | 
    155:
    PVSSD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    Pfam:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse HBGF-1
    Cat.:
    E0032h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse HBGF-1
    Cat.:
    E0032m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse HBGF-1
    Cat.:
    E0032r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse HBGF-1
    Cat.:
    E0032p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse HBGF-1
    Cat.:
    E0032b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse HBGF-1
    Cat.:
    E0032d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse HBGF-1
    Cat.:
    E0032c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse HBGF-1
    Cat.:
    U0032r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse HBGF-1
    Cat.:
    U0032p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse HBGF-1
    Cat.:
    U0032m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse HBGF-1
    Cat.:
    U0032h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse HBGF-1
    Cat.:
    U0032d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse HBGF-1
    Cat.:
    U0032b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse HBGF-1
    Cat.:
    U0032c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse HBGF-1
    Polyclonal Antibody for Mouse HBGF-1
    Polyclonal Antibody for Mouse HBGF-1
    Cat.:
    P0032Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse HBGF-1
    Polyclonal Antibody for Mouse HBGF-1
    Cat.:
    P0032Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse HBGF-1
    Cat.:
    P0032Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse HBGF-1
    Monoclonal Antibody for Mouse HBGF-1
    Monoclonal Antibody for Mouse HBGF-1
    Monoclonal Antibody for Mouse HBGF-1
    Monoclonal Antibody for Mouse HBGF-1
    Monoclonal Antibody for Mouse HBGF-1
    Monoclonal Antibody for Mouse HBGF-1
    Monoclonal Antibody for Mouse HBGF-1
    Protein for Mouse HBGF-1
    Protein for Mouse HBGF-1
    Protein for Mouse HBGF-1
    Protein for Mouse HBGF-1
    Protein for Mouse HBGF-1
    Protein for Mouse HBGF-1
    Protein for Mouse HBGF-1

    R&D Technical Data

    s

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    Precision

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤4.7%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤6.8%

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    Recovery

    Recovery was determined by spiking various levels of FGF1 into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    95

    93-97

    Plasma

    97

    96-102

     

     

     

     

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    Linearity

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of FGF1 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    92-100%

    97-104%

    95-98%

    91-96%

    EDTA plasma(n=5)

    89-93%

    102-105%

    94-97%

    93-98%

    heparin plasma(n=5)

    91-95%

     

    96-99%

    106-108%

    87-93%

     

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    References
    1. 1.
      "Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis."
      Hebert J.M. , Basilico C. , Goldfarb M. , Haub O. , Martin G.R.
      Dev. Biol.138:454-463(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Cloning and characterization of the mouse Fgf-1 gene."
      Madiai F. , Hackshaw K.V. , Chiu I.M.
      Gene179:231-236(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Characterization of the 1B promoter of fibroblast growth factor 1 and its expression in the adult and developing mouse brain."
      Alam K.Y. , Frostholm A. , Hackshaw K.V. , Evans J.E. , Rotter A. , Chiu I.M.
      J. Biol. Chem.271:30263-30271(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: BALB/c.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Liver.
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