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Index > Protein center > FLT3(Gene name) > Human
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  • FLT3 (Gene name),
  • Receptor-type tyrosine-protein kinase FLT3 (Protein name ),  FLT3_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    FLT3(CD135;FLK2;STK1);
    Protein name:
    Receptor-type tyrosine-protein kinase FLT3;
    Alternative:
    Fetal liver kinase-2(FLK-2);FL cytokine receptor;Stem cell tyrosine kinase 1(STK-1);Fms-like tyrosine kinase 3(FLT-3);
    CD:
    CD135;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer in the absence of bound FLT3LG. Homodimer in the presence of bound FLT3LG. One homodimer interacts with one FLT3LG molecule. Interacts with FIZ1 following ligand activation (By similarity). Interacts with FES, FER and GRB2. Interacts with PTPRJ/DEP-1 and PTPN11/SHP2.
    Function:
    Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
    Subcellular Location:
    Membrane Single-pass type I membrane protein Endoplasmic reticulum lumen Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation.
    Protein Attributes:
    Sequence length:
    993
    Sequence:
    50:
    MPALARDGGQ | LPLLVVFSAM | IFGTITNQDL | PVIKCVLINH | KNNDSSVGKS | 
    100:
    SSYPMVSESP | EDLGCALRPQ | SSGTVYEAAA | VEVDVSASIT | LQVLVDAPGN | 
    150:
    ISCLWVFKHS | SLNCQPHFDL | QNRGVVSMVI | LKMTETQAGE | YLLFIQSEAT | 
    200:
    NYTILFTVSI | RNTLLYTLRR | PYFRKMENQD | ALVCISESVP | EPIVEWVLCD | 
    250:
    SQGESCKEES | PAVVKKEEKV | LHELFGTDIR | CCARNELGRE | CTRLFTIDLN | 
    300:
    QTPQTTLPQL | FLKVGEPLWI | RCKAVHVNHG | FGLTWELENK | ALEEGNYFEM | 
    350:
    STYSTNRTMI | RILFAFVSSV | ARNDTGYYTC | SSSKHPSQSA | LVTIVEKGFI | 
    400:
    NATNSSEDYE | IDQYEEFCFS | VRFKAYPQIR | CTWTFSRKSF | PCEQKGLDNG | 
    450:
    YSISKFCNHK | HQPGEYIFHA | ENDDAQFTKM | FTLNIRRKPQ | VLAEASASQA | 
    500:
    SCFSDGYPLP | SWTWKKCSDK | SPNCTEEITE | GVWNRKANRK | VFGQWVSSST | 
    550:
    LNMSEAIKGF | LVKCCAYNSL | GTSCETILLN | SPGPFPFIQD | NISFYATIGV | 
    600:
    CLLFIVVLTL | LICHKYKKQF | RYESQLQMVQ | VTGSSDNEYF | YVDFREYEYD | 
    650:
    LKWEFPRENL | EFGKVLGSGA | FGKVMNATAY | GISKTGVSIQ | VAVKMLKEKA | 
    700:
    DSSEREALMS | ELKMMTQLGS | HENIVNLLGA | CTLSGPIYLI | FEYCCYGDLL | 
    750:
    NYLRSKREKF | HRTWTEIFKE | HNFSFYPTFQ | SHPNSSMPGS | REVQIHPDSD | 
    800:
    QISGLHGNSF | HSEDEIEYEN | QKRLEEEEDL | NVLTFEDLLC | FAYQVAKGME | 
    850:
    FLEFKSCVHR | DLAARNVLVT | HGKVVKICDF | GLARDIMSDS | NYVVRGNARL | 
    900:
    PVKWMAPESL | FEGIYTIKSD | VWSYGILLWE | IFSLGVNPYP | GIPVDANFYK | 
    950:
    LIQNGFKMDQ | PFYATEEIYI | IMQSCWAFDS | RKRPSFPNLT | SFLGCQLADA | 
    993:
    EEAMYQNVDG | RVSECPHTYQ | NRRPFSREMD | LGLLSPQAQV | EDS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    String:
    KEGG:
    Pfam:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Receptor-type tyrosine-protein kinase FLT3
    Cat.:
    E0039h
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    96T
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    ELISA Kit for Human Receptor-type tyrosine-protein kinase FLT3
    Cat.:
    E0039m
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    MSDS:
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    Packing:
    96T
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    CLIA Kit for Human Receptor-type tyrosine-protein kinase FLT3
    Cat.:
    U0039m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Receptor-type tyrosine-protein kinase FLT3
    Cat.:
    U0039h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    Polyclonal Antibody for Human Receptor-type tyrosine-protein kinase FLT3
    Cat.:
    P0039Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Receptor-type tyrosine-protein kinase FLT3
    Cat.:
    P0039Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Receptor-type tyrosine-protein kinase FLT3
    Monoclonal Antibody for Human Receptor-type tyrosine-protein kinase FLT3
    Protein for Human Receptor-type tyrosine-protein kinase FLT3
    Protein for Human Receptor-type tyrosine-protein kinase FLT3

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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    References
    1. 1.
      "STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells."
      Small D. , Levenstein M. , Kim E. , Carow C. , Amin S. , Rockwell P. , Witte L. , Burrow C. , Ratajczak M.Z. , Gewirtz A.M. , Civin C.I.
      Proc. Natl. Acad. Sci. U.S.A.91:459-463(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY
      tissue: Bone marrow.
    2. 2.
      "Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells."
      Rosnet O. , Schiff C. , Pebusque M.J. , Marchetto S. , Tonnelle C. , Toiron Y. , Birg F. , Birnbaum D.
      Blood82:1110-1119(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;VARIANT MET-227
      tissue: Lymphocyte.
    3. 3.
      "The DNA sequence and analysis of human chromosome 13."
      Dunham A. , Matthews L.H. , Burton J. , Ashurst J.L. , Howe K.L. , Ashcroft K.J. , Beare D.M. , Burford D.C. , Hunt S.E. , Griffiths-Jones S. , Jones M.C. , Keenan S.J. , Oliver K. , Scott C.E. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews D.T. , more...
      Nature428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT MET-227
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT MET-227
    6. 6.
      "Isolation and chromosomal localization of a novel FMS-like tyrosine kinase gene."
      Rosnet O. , Mattei M.-G. , Marchetto S. , Birnbaum D.
      Genomics9:380-385(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 783-942 (ISOFORM 1)
      tissue: Testis.
    7. 7.
      "Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells."
      Rosnet O. , Buhring H.J. , Marchetto S. , Rappold I. , Lavagna C. , Sainty D. , Arnoulet C. , Chabannon C. , Kanz L. , Hannum C. , Birnbaum D.
      Leukemia10:238-248(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;SUBCELLULAR LOCATION
    8. 8.
      "Internal tandem duplication of the flt3 gene found in acute myeloid leukemia."
      Nakao M. , Yokota S. , Iwai T. , Kaneko H. , Horiike S. , Kashima K. , Sonoda Y. , Fujimoto T. , Misawa S.
      Leukemia10:1911-1918(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN AML
    9. 9.
      "Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product."
      Kiyoi H. , Towatari M. , Yokota S. , Hamaguchi M. , Ohno R. , Saito H. , Naoe T.
      Leukemia12:1333-1337(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN AML;SUBUNIT;PHOSPHORYLATION;MUTAGENESIS OF TYR-589 AND TYR-591
    10. 10.
      "Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells."
      Zhang S. , Mantel C. , Broxmeyer H.E.
      J. Leukoc. Biol.65:372-380(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PROMOTING PHOSPHORYLATION OF SHC1; PTPN6/SHP; PTPN11/SHP-2; MAPK1/ERK2; MAPK3/ERK1;AUTOPHOSPHORYLATION;INTERACTION WITH GRB2
    11. 11.
      "Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways."
      Mizuki M. , Fenski R. , Halfter H. , Matsumura I. , Schmidt R. , Muller C. , Gruning W. , Kratz-Albers K. , Serve S. , Steur C. , Buchner T. , Kienast J. , Kanakura Y. , Berdel W.E. , Serve H.
      Blood96:3907-3914(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACTIVATION OF AKT1; MAPK1/ERK2; MAPK3/ERK1; STAT5A AND STAT5B;PHOSPHORYLATION;FUNCTION IN ACTIVATION OF THE RAS PATHWAY;INVOLVEMENT IN AML
    12. 12.
      "Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation."
      Brandts C.H. , Sargin B. , Rode M. , Biermann C. , Lindtner B. , Schwable J. , Buerger H. , Muller-Tidow C. , Choudhary C. , McMahon M. , Berdel W.E. , Serve H.
      Cancer Res.65:9643-9650(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACTIVATION OF AKT1;INVOLVEMENT IN AML
    13. 13.
      "Tyrosine phosphorylation regulates maturation of receptor tyrosine kinases."
      Schmidt-Arras D.E. , Bohmer A. , Markova B. , Choudhary C. , Serve H. , Bohmer F.D.
      Mol. Cell. Biol.25:3690-3703(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;CATALYTIC ACTIVITY;PHOSPHORYLATION AT TYR-591;DEPHOSPHORYLATION BY PTPN1; PTPN6/SHP-1 AND PTPN12;PROTEASOMAL DEGRADATION;GLYCOSYLATION;MUTAGENESIS OF LYS-644
    14. 14.
      "Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD."
      Rocnik J.L. , Okabe R. , Yu J.C. , Lee B.H. , Giese N. , Schenkein D.P. , Gilliland D.G.
      Blood108:1339-1345(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACTIVATION OF STAT5A AND/OR STAT5B;PHOSPHORYLATION AT TYR-591; TYR-726; TYR-842; TYR-955 AND TYR-969;IDENTIFICATION BY MASS SPECTROMETRY;MUTAGENESIS OF TYR-589 AND TYR-591
    15. 15.
      "Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2."
      Heiss E. , Masson K. , Sundberg C. , Pedersen M. , Sun J. , Bengtsson S. , Ronnstrand L.
      Blood108:1542-1550(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTPN11/SHP2; LYN; FGR; HCK AND SRC;AUTOPHOSPHORYLATION;MUTAGENESIS OF TYR-589 AND TYR-599;PHOSPHORYLATION AT TYR-572; SER-574; TYR-589; TYR-591 AND TYR-599
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REGION INVOLVED IN REGULATION OF KINASE ACTIVITY;AUTOREGULATORY DOMAIN;INVOLVEMENT IN AML
    17. 17.
      "Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival."
      Kikushige Y. , Yoshimoto G. , Miyamoto T. , Iino T. , Mori Y. , Iwasaki H. , Niiro H. , Takenaka K. , Nagafuji K. , Harada M. , Ishikawa F. , Akashi K.
      J. Immunol.180:7358-7367(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    18. 18.
      "Oncogenic Flt3 receptors display different specificity and kinetics of autophosphorylation."
      Razumovskaya E. , Masson K. , Khan R. , Bengtsson S. , Ronnstrand L.
      Exp. Hematol.37:979-989(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-589; TYR-591; TYR-599; TYR-726; TYR-768; TYR-793; TYR-842 AND TYR-955
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-759 AND SER-993;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    20. 20.
      "FES kinases are required for oncogenic FLT3 signaling."
      Voisset E. , Lopez S. , Chaix A. , Georges C. , Hanssens K. , Prebet T. , Dubreuil P. , De Sepulveda P.
      Leukemia24:721-728(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACTIVATION OF FES AND FER;INTERACTION WITH FES AND FER
    21. 21.
      "Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation."
      Buchwald M. , Pietschmann K. , Muller J.P. , Bohmer F.D. , Heinzel T. , Kramer O.H.
      Leukemia24:1412-1421(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION
    22. 22.
      "mTOR signaling is activated by FLT3 kinase and promotes survival of FLT3-mutated acute myeloid leukemia cells."
      Chen W. , Drakos E. , Grammatikakis I. , Schlette E.J. , Li J. , Leventaki V. , Staikou-Drakopoulou E. , Patsouris E. , Panayiotidis P. , Medeiros L.J. , Rassidakis G.Z.
      Mol. Cancer9:292-292(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    23. 23.
      "Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling."
      Arora D. , Stopp S. , Bohmer S.A. , Schons J. , Godfrey R. , Masson K. , Razumovskaya E. , Ronnstrand L. , Tanzer S. , Bauer R. , Bohmer F.D. , Muller J.P.
      J. Biol. Chem.286:10918-10929(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTPRJ/DEP1;FUNCTION IN ACTIVATION OF MAPK1/ERK2; MAPK3/ERK1; PLCG1; STAT5A AND/OR STAT5B;GLYCOSYLATION;UBIQUITINATION;PHOSPHORYLATION AT TYR-572; TYR-589; TYR-591; TYR-599; TYR-768; TYR-793; TYR-842 AND TYR-955
    24. 24.
      "Further activation of FLT3 mutants by FLT3 ligand."
      Zheng R. , Bailey E. , Nguyen B. , Yang X. , Piloto O. , Levis M. , Small D.
      Oncogene30:4004-4014(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION
    25. 25.
      "The role of FLT3 in haematopoietic malignancies."
      Stirewalt D.L. , Radich J.P.
      Nat. Rev. Cancer3:650-665(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    26. 26.
      "Structural and functional alterations of FLT3 in acute myeloid leukemia."
      Meshinchi S. , Appelbaum F.R.
      Clin. Cancer Res.15:4263-4269(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    27. 27.
      "The structural basis for autoinhibition of FLT3 by the juxtamembrane domain."
      Griffith J. , Black J. , Faerman C. , Swenson L. , Wynn M. , Lu F. , Lippke J. , Saxena K.
      Mol. Cell13:169-178(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 564-958;ENZYME REGULATION
    28. 28.
      "Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex."
      Verstraete K. , Vandriessche G. , Januar M. , Elegheert J. , Shkumatov A.V. , Desfosses A. , Van Craenenbroeck K. , Svergun D.I. , Gutsche I. , Vergauwen B. , Savvides S.N.
      Blood118:60-68(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (4.3 ANGSTROMS) OF 27-436 IN COMPLEX WITH FLT3LG;SUBUNIT;INTERACTION WITH FLT3LG;GLYCOSYLATION AT ASN-43; ASN-100; ASN-151; ASN-306; ASN-323; ASN-351 AND ASN-354;IDENTIFICATION BY MASS SPECTROMETRY;DISULFIDE BONDS
    29. 29.
      "Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia."
      Abu-Duhier F.M. , Goodeve A.C. , Wilson G.A. , Care R.S. , Peake I.R. , Reilly J.T.
      Br. J. Haematol.113:983-988(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS TYR-835 DEL; HIS-835 AND TYR-835;INVOLVEMENT IN AML
    30. 30.
      "Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies."
      Yamamoto Y. , Kiyoi H. , Nakano Y. , Suzuki R. , Kodera Y. , Miyawaki S. , Asou N. , Kuriyama K. , Yagasaki F. , Shimazaki C. , Akiyama H. , Saito K. , Nishimura M. , Motoji T. , Shinagawa K. , Takeshita A. , Saito H. , Ueda R. , more...
      Blood97:2434-2439(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASN-835; GLU-835; HIS-835; VAL-835 AND TYR-835;CHARACTERIZATION OF VARIANTS ASN-835; GLU-835; HIS-835; VAL-835 AND TYR-835;PHOSPHORYLATION;INVOLVEMENT IN AML
    31. 31.
      "FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy."
      Taketani T. , Taki T. , Sugita K. , Furuichi Y. , Ishii E. , Hanada R. , Tsuchida M. , Sugita K. , Ida K. , Hayashi Y.
      Blood103:1085-1088(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GLU-835; HIS-835; TYR-835; ILE-836 DEL AND MET-836;FUNCTION IN ACTIVATION OF STAT5A AND/OR STAT5B;PHOSPHORYLATION;INVOLVEMENT IN AML
    32. 33.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-194
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