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Index > Protein center > GDNF(Gene name) > Human
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  • GDNF (Gene name),
  • Glial cell line-derived neurotrophic factor (Protein name ),  GDNF_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    GDNF;
    Protein name:
    Glial cell line-derived neurotrophic factor(hGDNF);
    Alternative:
    Astrocyte-derived trophic factor(ATF);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer; disulfide-linked.
    Function:
    Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    211
    Sequence:
    50:
    MKLWDVVAVC | LVLLHTASAF | PLPAGKRPPE | APAEDRSLGR | RRAPFALSSD | 
    100:
    SNMPEDYPDQ | FDDVMDFIQA | TIKRLKRSPD | KQMAVLPRRE | RNRQAAAANP | 
    150:
    ENSRGKGRRG | QRGKNRGCVL | TAIHLNVTDL | GLGYETKEEL | IFRYCSGSCD | 
    200:
    AAETTYDKIL | KNLSRNRRLV | SDKVGQACCR | PIAFDDDLSF | LDDNLVYHIL | 
    211:
    RKHSAKRCGC | I
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    MIM:
    Pfam:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human hGDNF
    Cat.:
    E0043r
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human hGDNF
    Cat.:
    E0043h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human hGDNF
    Cat.:
    E0043m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human hGDNF
    Cat.:
    U0043m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human hGDNF
    Cat.:
    U0043h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human hGDNF
    Cat.:
    U0043r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human hGDNF
    Cat.:
    P0043Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human hGDNF
    Cat.:
    P0043Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human hGDNF
    Cat.:
    P0043Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human hGDNF
    Monoclonal Antibody for Human hGDNF
    Monoclonal Antibody for Human hGDNF
    Protein for Human hGDNF
    Protein for Human hGDNF
    Protein for Human hGDNF

    R&D Technical Data
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    s

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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤4.3%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.5%

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

    Recovery was determined by spiking various levels of GDNF into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    105

    102-108

    Plasma

    106

    99-107

     

     

     

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of GDNF and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    102-106%

    101-107%

    96-103%

    93-98%

    EDTA plasma(n=5)

    97-105%

    104-108%

    99-103%

    89-96%

    heparin plasma(n=5)

    104-106%

     

    107-110%

    95-99%

    100-105%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons."
      Lin L.-F.H. , Doherty D.H. , Lile J.D. , Bektesh S. , Collins F.
      Science260:1130-1132(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];FUNCTION;HOMODIMERIZATION;DISULFIDE BONDS
    2. 2.
      "Multiple astrocyte transcripts encode nigral trophic factors in rat and human."
      Schaar D.G. , Sieber B.-A. , Sherwood A.C. , Dean D. , Mendoza G. , Ramakrishnan L. , Dreyfus C.F. , Black I.B.
      Exp. Neurol.130:387-393(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);TISSUE SPECIFICITY
    3. 3.
      Zhang B. , Feng Z. , Zhou Y. , Peng X. , Yuan J. , Qiang B.
      Submitted (2001-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    4. 4.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    5. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    7. 8.
      "Characterization of a promoter for the human glial cell line-derived neurotrophic factor gene."
      Baecker P.A. , Lee W.H. , Verity A.N. , Eglen R.M. , Johnson R.M.
      Brain Res. Mol. Brain Res.69:209-222(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-187 (ISOFORM 1)
      tissue: Fetal kidney.
    8. 9.
      "The human GDNF gene promoter."
      Suter-Crazzolara C. , Baecker P.A. , Lee W.H. , Johnson R.M. , Unsicker K.
      Submitted (1997-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-88 (ISOFORM 2);NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-77;NUCLEOTIDE SEQUENCE [MRNA] OF 1-59 (ISOFORMS 3 AND 4)
      tissue: Brain.
      tissue: Kidney.
    9. 10.
      "Analysis of the human GDNF gene reveals an inducible promoter, three exons, a triplet repeat within the 3'-UTR and alternative splice products."
      Grimm L. , Holinski-Feder E. , Teodoridis J. , Scheffer B. , Schindelhauer D. , Meitinger T. , Ueffing M.
      Hum. Mol. Genet.7:1873-1886(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-50;SUBCELLULAR LOCATION;INDUCTION
    10. 11.
      "Glial cell line-derived neurotrophic factor: selective reduction of the intermolecular disulfide linkage and characterization of its disulfide structure."
      Haniu M. , Hui J. , Young Y. , Le J. , Katta V. , Lee R. , Shimamoto G. , Rohde M.F.
      Biochemistry35:16799-16805(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 87-122; 141-153; 173-184 AND 196-211;HOMODIMERIZATION;DISULFIDE BONDS
    11. 12.
      "Identification of novel GDNF isoforms and cis-antisense GDNFOS gene and their regulation in human middle temporal gyrus of Alzheimer disease."
      Airavaara M. , Pletnikova O. , Doyle M.E. , Zhang Y.E. , Troncoso J.C. , Liu Q.R.
      J. Biol. Chem.286:45093-45102(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORMS 1; 2; 3 AND 5);TISSUE SPECIFICITY
    12. 13.
      "Mutations in Hirschsprung disease: when does a mutation contribute to the phenotype."
      Hofstra R.M.W. , Osinga J. , Buys C.H.C.M.
      Eur. J. Hum. Genet.5:180-185(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON VARIANTS
    13. 14.
      "Comparison of GFL-GFRalpha complexes: further evidence relating GFL bend angle to RET signalling."
      Parkash V. , Goldman A.
      Acta Crystallogr. F65:551-558(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 78-211;GLYCOSYLATION AT ASN-126;DISULFIDE BONDS
    14. 15.
      "De novo mutation of GDNF, ligand for the RET/GDNFR-alpha receptor complex, in Hirschsprung disease."
      Ivanchuk S.M. , Myers S.M. , Eng C. , Mulligan L.M.
      Hum. Mol. Genet.5:2023-2026(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HSCR3 SER-154
    15. 16.
      "Germline mutations in glial cell line-derived neurotrophic factor (GDNF) and RET in a Hirschsprung disease patient."
      Angrist M. , Bolk S. , Halushka M. , Lapchak P.A. , Chakravarti A.
      Nat. Genet.14:341-344(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HSCR3 TRP-93
    16. 17.
      "Germline mutations of the RET ligand GDNF are not sufficient to cause Hirschsprung disease."
      Salomon R. , Attie T. , Pelet A. , Bidaud C. , Eng C. , Amiel J. , Sarnacki S. , Goulet O. , Ricour C. , Nihoul-Fekete C. , Munnich A. , Lyonnet S.
      Nat. Genet.14:345-347(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HSCR3 SER-21 AND ASN-150
    17. 18.
      "Mutations of the RET-GDNF signaling pathway in Ondine's curse."
      Amiel J. , Salomon R. , Attie T. , Pelet A. , Trang H. , Mokhtari M. , Gaultier C. , Munnich A. , Lyonnet S.
      Am. J. Hum. Genet.62:715-717(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CCHS TRP-93
    18. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HSCR3 MET-211
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