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Index > Protein center > JAK3(Gene name) > Human
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  • JAK3 (Gene name),
  • Tyrosine-protein kinase JAK3 (Protein name ),  JAK3_HUMAN from NCBI database.
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  • Gene name:
    JAK3;
    Protein name:
    Tyrosine-protein kinase JAK3;
    Alternative:
    Leukocyte janus kinase(L-JAK);Janus kinase 3(JAK-3);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with STAM2 and MYO18A (By similarity). Interacts with SHB.
    Function:
    Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.
    Subcellular Location:
    Endomembrane system Peripheral membrane protein Cytoplasm
    Protein Attributes:
    Sequence length:
    1124
    Sequence:
    50:
    MAPPSEETPL | IPQRSCSLLS | TEAGALHVLL | PARGPGPPQR | LSFSFGDHLA | 
    100:
    EDLCVQAAKA | SGILPVYHSL | FALATEDLSC | WFPPSHIFSV | EDASTQVLLY | 
    150:
    RIRFYFPNWF | GLEKCHRFGL | RKDLASAILD | LPVLEHLFAQ | HRSDLVSGRL | 
    200:
    PVGLSLKEQG | ECLSLAVLDL | ARMAREQAQR | PGELLKTVSY | KACLPPSLRD | 
    250:
    LIQGLSFVTR | RRIRRTVRRA | LRRVAACQAD | RHSLMAKYIM | DLERLDPAGA | 
    300:
    AETFHVGLPG | ALGGHDGLGL | LRVAGDGGIA | WTQGEQEVLQ | PFCDFPEIVD | 
    350:
    ISIKQAPRVG | PAGEHRLVTV | TRTDNQILEA | EFPGLPEALS | FVALVDGYFR | 
    400:
    LTTDSQHFFC | KEVAPPRLLE | EVAEQCHGPI | TLDFAINKLK | TGGSRPGSYV | 
    450:
    LRRSPQDFDS | FLLTVCVQNP | LGPDYKGCLI | RRSPTGTFLL | VGLSRPHSSL | 
    500:
    RELLATCWDG | GLHVDGVAVT | LTSCCIPRPK | EKSNLIVVQR | GHSPPTSSLV | 
    550:
    QPQSQYQLSQ | MTFHKIPADS | LEWHENLGHG | SFTKIYRGCR | HEVVDGEARK | 
    600:
    TEVLLKVMDA | KHKNCMESFL | EAASLMSQVS | YRHLVLLHGV | CMAGDSTMVQ | 
    650:
    EFVHLGAIDM | YLRKRGHLVP | ASWKLQVVKQ | LAYALNYLED | KGLPHGNVSA | 
    700:
    RKVLLAREGA | DGSPPFIKLS | DPGVSPAVLS | LEMLTDRIPW | VAPECLREAQ | 
    750:
    TLSLEADKWG | FGATVWEVFS | GVTMPISALD | PAKKLQFYED | RQQLPAPKWT | 
    800:
    ELALLIQQCM | AYEPVQRPSF | RAVIRDLNSL | ISSDYELLSD | PTPGALAPRD | 
    850:
    GLWNGAQLYA | CQDPTIFEER | HLKYISQLGK | GNFGSVELCR | YDPLGDNTGA | 
    900:
    LVAVKQLQHS | GPDQQRDFQR | EIQILKALHS | DFIVKYRGVS | YGPGRQSLRL | 
    950:
    VMEYLPSGCL | RDFLQRHRAR | LDASRLLLYS | SQICKGMEYL | GSRRCVHRDL | 
    1000:
    AARNILVESE | AHVKIADFGL | AKLLPLDKDY | YVVREPGQSP | IFWYAPESLS | 
    1050:
    DNIFSRQSDV | WSFGVVLYEL | FTYCDKSCSP | SAEFLRMMGC | ERDVPALCRL | 
    1100:
    LELLEEGQRL | PAPPACPAEV | HELMKLCWAP | SPQDRPSFSA | LGPQLDMLWS | 
    1124:
    GSRGCETHAF | TAHPEGKHHS | LSFS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    MIM:
    String:
    SMR:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Tyrosine-protein kinase JAK3
    Cat.:
    E0425r
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Tyrosine-protein kinase JAK3
    Cat.:
    E0425h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Tyrosine-protein kinase JAK3
    Cat.:
    E0425m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Tyrosine-protein kinase JAK3
    Cat.:
    U0425r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Tyrosine-protein kinase JAK3
    Cat.:
    U0425m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Tyrosine-protein kinase JAK3
    Cat.:
    U0425h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Tyrosine-protein kinase JAK3
    Cat.:
    P0425Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Tyrosine-protein kinase JAK3
    Cat.:
    P0425Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Tyrosine-protein kinase JAK3
    Cat.:
    P0425Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Tyrosine-protein kinase JAK3
    Monoclonal Antibody for Human Tyrosine-protein kinase JAK3
    Monoclonal Antibody for Human Tyrosine-protein kinase JAK3
    Protein for Human Tyrosine-protein kinase JAK3
    Protein for Human Tyrosine-protein kinase JAK3
    Protein for Human Tyrosine-protein kinase JAK3

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    s
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
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    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤3.9%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.7%

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

    Recovery was determined by spiking various levels of JAK3 into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    99

    91-103

    Plasma

    98

    93-106

     

     

     

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of JAK3 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    92-105%

    90-101%

    95-105%

    92-109%

    EDTA plasma(n=5)

    89-95%

    93105%

    89-94%

    90-106%

    heparin plasma(n=5)

    93-104%

     

    94-110%

    101-111%

    91-110%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes."
      Kawamura M. , McVicar D.W. , Johnston J.A. , Blake T.B. , Chen Y.-Q. , Lal B.K. , Lloyd A.R. , Kelvin D.J. , Staples J.E. , Ortaldo J.R. , O'Shea J.J.
      Proc. Natl. Acad. Sci. U.S.A.91:6374-6378(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    2. 2.
      "A kinase-deficient splice variant of the human JAK3 is expressed in hematopoietic and epithelial cancer cells."
      Lai K.S. , Jin Y. , Graham D.K. , Witthuhn B.A. , Ihle J.N. , Liu E.T.
      J. Biol. Chem.270:25028-25036(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);ALTERNATIVE SPLICING (ISOFORM 2)
    3. 3.
      "Genomic sequence, organization, and chromosomal localization of human JAK3."
      Riedy M.C. , Dutra A.S. , Blake T.B. , Modi W. , Lal B.K. , Davis J. , Bosse A. , O'Shea J.J. , Johnston J.A.
      Genomics37:57-61(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      SeattleSNPs variation discovery resource
      Submitted (2002-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS THR-132 AND ILE-722
    5. 5.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Blood.
    8. 8.
      "Expression of Janus kinase 3 in human endothelial and other non-lymphoid and non-myeloid cells."
      Verbsky J.W. , Bach E.A. , Fang Y.F. , Yang L. , Randolph D.A. , Fields L.E.
      J. Biol. Chem.271:13976-13980(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-191
    9. 9.
      "Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2."
      Johnston J.A. , Kawamura M. , Kirken R.A. , Chen Y.Q. , Blake T.B. , Shibuya K. , Ortaldo J.R. , McVicar D.W. , O'Shea J.J.
      Nature370:151-153(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN IL2 SIGNALING PATHWAY
    10. 10.
      "JAK3 protein tyrosine kinase mediates interleukin-7-induced activation of phosphatidylinositol-3' kinase."
      Sharfe N. , Dadi H.K. , Roifman C.M.
      Blood86:2077-2085(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN IL7 SIGNALING PATHWAY
    11. 11.
      "Regulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7."
      Musso T. , Johnston J.A. , Linnekin D. , Varesio L. , Rowe T.K. , O'Shea J.J. , McVicar D.W.
      J. Exp. Med.181:1425-1431(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    12. 12.
      "STAM2, a new member of the STAM family, binding to the Janus kinases."
      Endo K. , Takeshita T. , Kasai H. , Sasaki Y. , Tanaka N. , Asao H. , Kikuchi K. , Yamada M. , Chenb M. , O'Shea J.J. , Sugamura K.
      FEBS Lett.477:55-61(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STAM2
      tissue: Fetal brain.
    13. 13.
      "IL-2 receptor signaling through the Shb adapter protein in T and NK cells."
      Lindholm C.K.
      Biochem. Biophys. Res. Commun.296:929-936(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SHB
    14. 14.
      "The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3."
      Simoncic P.D. , Lee-Loy A. , Barber D.L. , Tremblay M.L. , McGlade C.J.
      Curr. Biol.12:446-453(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CYTOKINE SIGNALING;PHOSPHORYLATION;DEPHOSPHORYLATION AT TYR-980 AND TYR-981 BY PTPN2
    15. 15.
      "The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction."
      Saharinen P. , Silvennoinen O.
      J. Biol. Chem.277:47954-47963(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN
    16. 16.
      "Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta."
      Kurzer J.H. , Argetsinger L.S. , Zhou Y.J. , Kouadio J.L. , O'Shea J.J. , Carter-Su C.
      Mol. Cell. Biol.24:4557-4570(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-785;MUTAGENESIS OF TYR-785
    17. 17.
      "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
      Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 18.
      "Phosphorylation of human Jak3 at tyrosines 904 and 939 positively regulates its activity."
      Cheng H. , Ross J.A. , Frost J.A. , Kirken R.A.
      Mol. Cell. Biol.28:2271-2282(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-904 AND TYR-939;MUTAGENESIS OF LYS-855; TYR-904 AND TYR-939
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
    20. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    21. 21.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    22. 22.
      "IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis."
      Malamut G. , El Machhour R. , Montcuquet N. , Martin-Lanneree S. , Dusanter-Fourt I. , Verkarre V. , Mention J.J. , Rahmi G. , Kiyono H. , Butz E.A. , Brousse N. , Cellier C. , Cerf-Bensussan N. , Meresse B.
      J. Clin. Invest.120:2131-2143(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN IL15 SIGNALING PATHWAY
    23. 23.
      "Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog."
      Boggon T.J. , Li Y. , Manley P.W. , Eck M.J.
      Blood106:996-1002(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 814-1103 IN COMPLEX WITH STAUROSPORINE ANALOG AFN941;PHOSPHORYLATION AT TYR-980 AND TYR-981
    24. 24.
      "Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)."
      Macchi P. , Villa A. , Giliani S. , Sacco M.G. , Frattini A. , Porta F. , Ugazio A.G. , Johnston J.A. , Candotti F. , O'Shea J.J. , Vezzoni P. , Notarangelo L.D.
      Nature377:65-68(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT T(-)B(+)NK(-) SCID CYS-100
    25. 25.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS T(-)B(+)NK(-) SCID GLY-481; 586-LEU--MET-592 DEL AND ARG-759
    26. 26.
      "Molecular and biochemical characterization of JAK3 deficiency in a patient with severe combined immunodeficiency over 20 years after bone marrow transplantation: implications for treatment."
      Bozzi F. , Lefranc G. , Villa A. , Badolato R. , Schumacher R.F. , Khalil G. , Loiselet J. , Bresciani S. , O'Shea J.J. , Vezzoni P. , Notarangelo L.D. , Candotti F.
      Br. J. Haematol.102:1363-1366(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT T(-)B(+)NK(-) SCID TRP-582
    27. 27.
      "Complete genomic organization of the human JAK3 gene and mutation analysis in severe combined immunodeficiency by single-strand conformation polymorphism."
      Schumacher R.F. , Mella P. , Badolato R. , Fiorini M. , Savoldi G. , Giliani S. , Villa A. , Candotti F. , Tampalini A. , O'Shea J.J. , Notarangelo L.D.
      Hum. Genet.106:73-79(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS T(-)B(+)NK(-) SCID ARG-151 AND SER-910;VARIANT ILE-722
    28. 28.
      "Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation."
      Roberts J.L. , Lengi A. , Brown S.M. , Chen M. , Zhou Y.-J. , O'Shea J.J. , Buckley R.H.
      Blood103:2009-2018(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS T(-)B(+)NK(-) SCID ALA-58 DEL; GLU-169 AND SER-589;VARIANT ILE-722
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