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Index > Protein center > Lrp2(Gene name) > Mouse
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  • Lrp2 (Gene name),
  • Low-density lipoprotein receptor-related protein 2 (Protein name ),  LRP2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Lrp2;
    Protein name:
    Low-density lipoprotein receptor-related protein 2(LRP-2);
    Alternative:
    Megalin;Glycoprotein 330(gp330);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Binds plasminogen, extracellular matrix components, plasminogen activator-plasminogen activator inhibitor type I complex, apolipoprotein E-enriched beta-VLDL, lipoprotein lipase, lactoferrin, CLU/clusterin and calcium. Forms a multimeric complex together with a receptor-associated protein (RAP). Binds to ankyrin-repeat family A protein 2 (ANKRA2). Interacts with LRP2BP.
    Function:
    Acts together with cubilin to mediate HDL endocytosis.
    Subcellular Location:
    Membrane Single-pass type I membrane protein Membrane coated pit
    Protein Attributes:
    Sequence length:
    4660
    Sequence:
    50:
    MERGAAAAAW | MLLLAIAACL | APVSGQECGS | GNFRCDNGYC | IPASWRCDGT | 
    100:
    RDCLDDTDEI | GCPPRSCGSG | FFLCPAEGTC | IPSSWVCDQD | KDCSDGADEQ | 
    150:
    QNCPGTTCSS | QQLTCSNGQC | VPIEYRCDHV | SDCPDGSDER | NCYYPTCDQL | 
    200:
    TCANGACYNT | SQKCDHKVDC | RDSSDEANCT | TLCSQKEFQC | GSGECILRAY | 
    250:
    VCDHDNDCED | NSDEHNCNYD | TCGGHQFTCS | NGQCINQNWV | CDGDDDCQDS | 
    300:
    GDEDGCESNQ | RHHTCYPREW | ACPGSGRCIS | MDKVCDGVPD | CPEGEDENNA | 
    350:
    TSGRYCGTGL | CSILNCEYQC | HQTPYGGECF | CPPGHIINSN | DSRTCIDFDD | 
    400:
    CQIWGICDQK | CESRQGRHQC | LCEEGYILER | GQHCKSNDSF | SAASIIFSNG | 
    450:
    RDLLVGDLHG | RNFRILAESK | NRGIVMGVDF | HYQKHRVFWT | DPMQAKVFST | 
    500:
    DINGLNTQEI | LNVSIDAPEN | LAVDWINNKL | YLVETRVNRI | DVVNLEGNQR | 
    550:
    VTLITENLGH | PRGIALDPTV | GYLFFSDWGS | LSGQPKVERA | FMDGSNRKDL | 
    600:
    VTTKLGWPAG | ITLDLVSKRV | YWVDSRYDYI | ETVTYDGIQR | KTVARGGSLV | 
    650:
    PHPFGISLFE | EHVFFTDWTK | MAVMKANKFT | DTNPQVYHQS | SLTPFGVTVY | 
    700:
    HALRQPNATN | PCGNNNGGCA | QICVLSHRTD | NGGLGYRCKC | EFGFELDADE | 
    750:
    HHCVAVKNFL | LFSSQTAVRG | IPFTLSTQED | VMVPVTGSPS | FFVGIDFDAQ | 
    800:
    HSTIFYSDLS | KNIIYQQKID | GTGKEVITAN | RLQNVECLSF | DWISRNLYWT | 
    850:
    DGGSKSVTVM | KLADKSRRQI | ISNLNNPRSI | VVHPAAGYMF | LSDWFRPAKI | 
    900:
    MRAWSDGSHL | MPIVNTSLGW | PNGLAIDWST | SRLYWVDAFF | DKIEHSNLDG | 
    950:
    LDRKRLGHVD | QMTHPFGLTV | FKDNVFLTDW | RLGAIIRVRK | SDGGDMTVVR | 
    1000:
    RGISSIMHVK | AYDADLQTGT | NYCSQTTHPN | GDCSHFCFPV | PNFQRVCGCP | 
    1050:
    YGMKLQRDQM | TCEGDPAREP | PTQQCGSSSF | PCNNGKCVPS | IFRCDGVDDC | 
    1100:
    HDNSDEHQCG | ALNNTCSSSA | FTCVHGGQCI | PGQWRCDKQN | DCLDGSDEQN | 
    1150:
    CPTRSPSSTC | PPTSFTCDNH | MCIPKEWVCD | TDNDCSDGSD | EKNCQASGTC | 
    1200:
    HPTQFRCPDH | RCISPLYVCD | GDKDCVDGSD | EAGCVLNCTS | SQFKCADGSS | 
    1250:
    CINSRYRCDG | VYDCKDNSDE | AGCPTRPPGM | CHPDEFQCQG | DGTCIPNTWE | 
    1300:
    CDGHPDCIQG | SDEHNGCVPK | TCSPSHFLCD | NGNCIYNSWV | CDGDNDCRDM | 
    1350:
    SDEKDCPTQP | FHCPSSQWQC | PGYSICVNLS | ALCDGVFDCP | NGTDESPLCN | 
    1400:
    QDSCLHFNGG | CTHRCIQGPF | GATCVCPIGY | QLANDTKTCE | DVNECDIPGF | 
    1450:
    CSQHCVNMRG | SFRCACDPEY | TLESDGRTCK | VTASENLLLV | VASRDKIIMD | 
    1500:
    NITAHTHNIY | SLVQDVSFVV | ALDFDSVTGR | VFWSDLLEGK | TWSAFQNGTD | 
    1550:
    KRVVHDSGLS | LTEMIAVDWI | GRNIYWTDYT | LETIEVSKID | GSHRTVLISK | 
    1600:
    NVTKPRGLAL | DPRMGDNVMF | WSDWGHHPRI | ERASMDGTMR | TVIVQEKIYW | 
    1650:
    PCGLSIDYPN | RLIYFMDAYL | DYIEFCDYDG | QNRRQVIASD | LVLHHPHALT | 
    1700:
    LFEDSVFWTD | RGTHQVMQAN | KWHGRNQSVV | MYSVPQPLGI | IAIHPSRQPS | 
    1750:
    SPNPCASATC | SHLCLLSAQE | PRHYSCACPS | GWNLSDDSVN | CVRGDQPFLI | 
    1800:
    SVRENVIFGI | SLDPEVKSND | AMVPISGIQH | GYDVEFDDSE | QFIYWVENPG | 
    1850:
    EIHRVKTDGS | NRTAFAPLSL | LGSSLGLALD | WVSRNIYYTT | PASRSIEVLT | 
    1900:
    LRGDTRYGKT | LITNDGTPLG | VGFPVGIAVD | PARGKLYWSD | HGTDSGVPAK | 
    1950:
    IASANMDGTS | LKILFTGNME | HLEVVTLDIQ | EQKLYWAVTS | RGVIERGNVD | 
    2000:
    GTERMILVHH | LAHPWGLVVH | GSFLYYSDEQ | YEVIERVDKS | SGSNKVVFRD | 
    2050:
    NIPYLRGLRV | YHHRNAADSS | NGCSNNPNAC | QQICLPVPGG | MFSCACASGF | 
    2100:
    KLSPDGRSCS | PYNSFIVVSM | LPAVRGFSLE | LSDHSEAMVP | VAGQGRNVLH | 
    2150:
    ADVDVANGFI | YWCDFSSSVR | SSNGIRRIKP | NGSNFTNIVT | YGIGANGIRG | 
    2200:
    VAVDWVAGNL | YFTNAFVYET | LIEVIRINTT | YRRVLLKVSV | DMPRHIVVDP | 
    2250:
    KHRYLFWADY | GQKPKIERSF | LDCTNRTVLV | SEGIVTPRGL | AVDHDTGYIY | 
    2300:
    WVDDSLDIIA | RIHRDGGESQ | VVRYGSRYPT | PYGITVFGES | IIWVDRNLRK | 
    2350:
    VFQASKQPGN | TDPPTVIRDS | INLLRDVTIF | DEHVQPLSPA | ELNNNPCLQS | 
    2400:
    NGGCSHFCFA | LPELPTPKCG | CAFGTLEDDG | KNCATSREDF | LIYSLNNSLR | 
    2450:
    SLHFDPQDHN | LPFQAISVEG | MAIALDYDRR | NNRIFFTQKL | NPIRGQISYV | 
    2500:
    NLYSGASSPT | ILLSNIGVTD | GIAFDWINRR | IYYSDFSNQT | INSMAEDGSN | 
    2550:
    RAVIARVSKP | RAIVLDPCRG | YMYWTDWGTN | AKIERATLGG | NFRVPIVNTS | 
    2600:
    LVWPNGLTLD | LETDLLYWAD | ASLQKIERST | LTGSNREVVI | STAFHSFGLT | 
    2650:
    VYGQYIYWTD | FYTKKIYRAN | KYDGSDLIAM | TTRLPTQPSG | ISTVVKTQQQ | 
    2700:
    QCSNPCDQFN | GGCSHICAPG | PNGAECQCPH | EGSWYLANDN | KYCVVDTGAR | 
    2750:
    CNQFQFTCLN | GRCISQDWKC | DNDNDCGDGS | DELPTVCAFH | TCRSTAFTCA | 
    2800:
    NGRCVPYHYR | CDFYNDCGDN | SDEAGCLFRS | CNSTTEFTCS | NGRCIPLSYV | 
    2850:
    CNGINNCHDN | DTSDEKNCPP | ITCQPDFAKC | QTTNICVPRA | FLCDGDNDCG | 
    2900:
    DGSDENPIYC | ASHTCRSNEF | QCVSPHRCIP | SYWFCDGEAD | CVDSSDEPDT | 
    2950:
    CGHSLNSCSA | NQFHCDNGRC | ISSSWVCDGD | NDCGDMSDED | QRHHCELQNC | 
    3000:
    SSTEFTCINS | RPPNRRCIPQ | HWVCDGDADC | ADALDELQNC | TMRACSTGEF | 
    3050:
    SCANGRCIRQ | SFRCDRRNDC | GDYSDERGCS | YPPCRDDQFT | CQNGQCITKL | 
    3100:
    YVCDEDNDCG | DGSDEQEHLC | HTPEPTCPPH | QFRCDNGHCI | EMGTVCNHVD | 
    3150:
    DCSDNSDEKG | CGINECQDSS | ISHCDHNCTD | TITSFYCSCL | PGYKLMSDKR | 
    3200:
    TCVDIDECKE | TPQLCSQKCE | NVIGSYICKC | APGYIREPDG | KSCRQNSNIE | 
    3250:
    PYLVFSNRYY | IRNLTIDGTS | YSLILQGLGN | VVALDFDRVE | ERLYWIDAEK | 
    3300:
    QIIERMFLNK | TNQETIISHR | LRRAESLAVD | WVSRKLYWLD | AILDCLFVSD | 
    3350:
    LEGRQRKMLA | QHCVDANNTF | CFENPRGIVL | HPQRGYVYWA | DWGDHAYIAR | 
    3400:
    IGMDGTNKTV | IISTKIEWPN | AITIDYTNDL | LYWADAHLGY | IEFSDLEGHH | 
    3450:
    RHTVYDGTLP | HPFALTIFED | TVFWTDWNTR | TVEKGNKYDG | SGRVVLVNTT | 
    3500:
    HKPFDIHVLH | PYRQPIMSNP | CATNNGGCSH | LCLIKAGGRG | FTCECPDDFQ | 
    3550:
    TVQLRDRTLC | MPMCSSTQFL | CGNNEKCIPI | WWKCDGQKDC | SDGSDESDLC | 
    3600:
    PHRFCRLGQF | QCRDGNCTSP | QALCNARQDC | ADGSDEDRVL | CEHHRCEANE | 
    3650:
    WQCANKRCIP | EYWQCDSVDD | CLDNSDEDPS | HCASRTCRPG | QFKCNNGRCI | 
    3700:
    PQSWKCDVDN | DCGDYSDEPI | HECMTAAYNC | DNHTEFSCKT | NYRCIPQWAV | 
    3750:
    CNGFDDCRDN | SDEQGCESVP | CHPSGDFRCG | NHHCIPLRWK | CDGIDDCGDN | 
    3800:
    SDEESCVPRE | CTESEFRCAD | QQCIPSRWVC | DQENDCGDNS | DERDCEMKTC | 
    3850:
    HPEHFQCTSG | HCVPKALACD | GRADCLDASD | ESACPTRFPN | GTYCPAAMFE | 
    3900:
    CKNHVCIQSF | WICDGENDCV | DGSDEEIHLC | FNVPCESPQR | FRCDNSRCIY | 
    3950:
    GHQLCNGVDD | CGDGSDEKEE | HCRKPTHKPC | TDTEYKCSNG | NCVSQHYVCD | 
    4000:
    NVDDCGDLSD | ETGCNLGENR | TCAEKICEQN | CTQLSNGGFI | CSCRPGFKPS | 
    4050:
    TLDKNSCQDI | NECEEFGICP | QSCRNSKGSY | ECFCVDGFKS | MSTHYGERCA | 
    4100:
    ADGSPPLLLL | PENVRIRKYN | ISSEKFSEYL | EEEEHIQAID | YDWDPEGIGL | 
    4150:
    SVVYYTVLSQ | GSQFGAIKRA | YLPDFESGSN | NPVREVDLGL | KYLMQPDGLA | 
    4200:
    VDWVGRHIYW | SDAKSQRIEV | ATLDGRYRKW | LITTQLDQPA | AIAVNPKLGL | 
    4250:
    MFWTDQGKQP | KIESAWMNGE | HRSVLASANL | GWPNGLSIDY | LNGDRIYWSD | 
    4300:
    SKEDVIESIK | YDGTDRRLII | NDAMKPFSLD | IFEDQLYWVA | KEKGEVWRQN | 
    4350:
    KFGKGNKEKL | LVVNPWLTQV | RIFHQLRYNQ | SVSNPCKQVC | SHLCLLRPGG | 
    4400:
    YSCACPQGSD | FVTGSTVECD | AASELPITMP | SPCRCMHGGS | CYFDENDLPK | 
    4450:
    CKCSSGYSGE | YCEIGLSRGI | PPGTTMALLL | TFAMVIIVGA | LVLVGFFHYR | 
    4500:
    KTGSLLPSLP | KLPSLSSLAK | PSENGNGVTF | RSGADVNMDI | GVSPFGPETI | 
    4550:
    IDRSMAMNEQ | FVMEVGKQPV | IFENPMYAAK | DSTSKVGLAV | QGPSVSSQVT | 
    4600:
    VPENVENQNY | GRSIDPSEIV | PEPKPASPGA | DETQGTKWNI | FKRKPKQTTN | 
    4650:
    FENPIYAEMD | TEQKEAVAVA | PPPSPSLPAK | ASKRSSTPGY | TATEDTFKDT | 
    4660:
    ANLVKEDSDV | 
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    Pfam:
    SMR:
    KEGG:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse LRP-2
    Cat.:
    E0001r
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    MSDS:
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    96T
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    ELISA Kit for Mouse LRP-2
    Cat.:
    E0001m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse LRP-2
    Cat.:
    E0001h
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Mouse LRP-2
    Cat.:
    U0001h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Mouse LRP-2
    Cat.:
    U0001m
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse LRP-2
    Cat.:
    U0001r
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Mouse LRP-2
    Cat.:
    P0001Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse LRP-2
    Cat.:
    P0001Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse LRP-2
    Cat.:
    P0001Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse LRP-2
    Monoclonal Antibody for Mouse LRP-2
    Monoclonal Antibody for Mouse LRP-2
    Protein for Mouse LRP-2
    Protein for Mouse LRP-2
    Protein for Mouse LRP-2

    R&D Technical Data
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4054-4660
      strain: C57BL/6J.
    3. 3.
      "Tubular modulation of clusterin in lupus-like glomerulonephritis."
      Moll S. , Menoud P.A. , Izui S.
      Submitted (1996-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4198-4320
      strain: NMRI.
      tissue: Kidney.
    4. 4.
      "Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins."
      Hammad S.M. , Barth J.L. , Knaak C. , Argraves W.S.
      J. Biol. Chem.275:12003-12008(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4465-4660;FUNCTION
    5. 5.
      "Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2."
      Morris S.M. , Cooper J.A.
      Traffic2:111-123(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DAB2
    6. 6.
      "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
      Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-387 AND ASN-399
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