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Index > Protein center > MMP1(Gene name) > Human
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  • MMP1 (Gene name),
  • Interstitial collagenase (Protein name ),  MMP1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    MMP1(CLG);
    Protein name:
    Interstitial collagenase;
    Alternative:
    Fibroblast collagenase;Matrix metalloproteinase-1(MMP-1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with HIV-1 Tat.
    Function:
    Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.
    Subcellular Location:
    Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    469
    Sequence:
    50:
    MHSFPPLLLL | LFWGVVSHSF | PATLETQEQD | VDLVQKYLEK | YYNLKNDGRQ | 
    100:
    VEKRRNSGPV | VEKLKQMQEF | FGLKVTGKPD | AETLKVMKQP | RCGVPDVAQF | 
    150:
    VLTEGNPRWE | QTHLTYRIEN | YTPDLPRADV | DHAIEKAFQL | WSNVTPLTFT | 
    200:
    KVSEGQADIM | ISFVRGDHRD | NSPFDGPGGN | LAHAFQPGPG | IGGDAHFDED | 
    250:
    ERWTNNFREY | NLHRVAAHEL | GHSLGLSHST | DIGALMYPSY | TFSGDVQLAQ | 
    300:
    DDIDGIQAIY | GRSQNPVQPI | GPQTPKACDS | KLTFDAITTI | RGEVMFFKDR | 
    350:
    FYMRTNPFYP | EVELNFISVF | WPQLPNGLEA | AYEFADRDEV | RFFKGNKYWA | 
    400:
    VQGQNVLHGY | PKDIYSSFGF | PRTVKHIDAA | LSEENTGKTY | FFVANKYWRY | 
    450:
    DEYKRSMDPG | YPKMIAHDFP | GIGHKVDAVF | MKDGFFYFFH | GTRQYKFDPK | 
    469:
    TKRILTLQKA | NSWFNCRKN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    UniGene:
    Pfam:
    MIM:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Interstitial collagenase
    Cat.:
    E0097b
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    ELISA Kit for Human Interstitial collagenase
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    E0097h
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    96T
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    ELISA Kit for Human Interstitial collagenase
    Cat.:
    E0097r
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    96T
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    ELISA Kit for Human Interstitial collagenase
    MSDS:
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    ELISA Kit for Human Interstitial collagenase
    Cat.:
    E0097p
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Interstitial collagenase
    Cat.:
    U0097p
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Interstitial collagenase
    MSDS:
    Please sign in first.
    CLIA Kit for Human Interstitial collagenase
    Cat.:
    U0097b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Interstitial collagenase
    Cat.:
    U0097r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Interstitial collagenase
    Cat.:
    U0097h
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
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    Polyclonal Antibody for Human Interstitial collagenase
    Polyclonal Antibody for Human Interstitial collagenase
    Polyclonal Antibody for Human Interstitial collagenase
    Cat.:
    P0097Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Interstitial collagenase
    Polyclonal Antibody for Human Interstitial collagenase
    Cat.:
    P0097Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Interstitial collagenase
    Monoclonal Antibody for Human Interstitial collagenase
    Monoclonal Antibody for Human Interstitial collagenase
    Monoclonal Antibody for Human Interstitial collagenase
    Monoclonal Antibody for Human Interstitial collagenase
    Protein for Human Interstitial collagenase
    Protein for Human Interstitial collagenase
    Protein for Human Interstitial collagenase
    Protein for Human Interstitial collagenase
    Protein for Human Interstitial collagenase

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    References
    1. 1.
      "Cloning and characterization of human tumor cell interstitial collagenase."
      Templeton N.S. , Brown P.D. , Levy A.T. , Margulies I.M.K. , Liotta L.A. , Stetler-Stevenson W.G.
      Cancer Res.50:5431-5437(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION
    2. 2.
      "Comparison of human stromelysin and collagenase by cloning and sequence analysis."
      Whitham S.E. , Murphy G. , Angel P. , Rahmsdorf H.J. , Smith B. , Lyons A. , Harris T.J.R. , Reynolds J.J. , Herrlich P. , Docherty A.J.P.
      Biochem. J.240:913-916(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein."
      Goldberg G.I. , Wilhelm S.M. , Kronberger A. , Bauer E.A. , Grant G.A. , Eisen A.Z.
      J. Biol. Chem.261:6600-6605(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      "Three matrix metalloproteinases on 81kb of P1 insert."
      Lin D. , Duncan M. , Allen E. , Araujo R. , Aparicio A. , Chai A. , Chung E. , Davis K. , Federspiel N. , Hyman R. , Kalman S. , Komp C. , Kurdi O. , Lashkari D. , Lew H. , Namath A. , Oefner P. , Roberts D. , more...
      Submitted (1996-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    6. 6.
      NIEHS SNPs program
      Submitted (2004-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS VAL-191; GLN-405 AND THR-406
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Ovary.
    8. 8.
      "12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region."
      Angel P. , Baumann I. , Stein B. , Delius H. , Rahmsdorf H.J. , Herrlich P.
      Mol. Cell. Biol.7:2256-2266(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-35
    9. 9.
      "Molecular cloning of human synovial cell collagenase and selection of a single gene from genomic DNA."
      Brinckerhoff C.E. , Ruby P.L. , Austin S.D. , Fini M.E. , White H.D.
      J. Clin. Invest.79:542-546(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-70
      tissue: Synovial cell.
    10. 10.
      "Fragments of human fibroblast collagenase. Purification and characterization."
      Clark I.M. , Cawston T.E.
      Biochem. J.263:201-206(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 100-112 AND 270-287
      tissue: Fibroblast.
    11. 11.
      "Human fibroblast collagenase contains an amino acid sequence homologous to the zinc-binding site of Serratia protease."
      McKerrow J.H.
      J. Biol. Chem.262:5943-5943(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SIMILARITY TO THERMOLYSIN TYPE PROTEASES
    12. 12.
      "Interstitial collagenase (matrix metalloproteinase-1) expresses serpinase activity."
      Desrochers P.E. , Jeffrey J.J. , Weiss S.J.
      J. Clin. Invest.87:2258-2265(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    13. 13.
      "N-glycan structures of matrix metalloproteinase-1 derived from human fibroblasts and from HT-1080 fibrosarcoma cells."
      Saarinen J. , Welgus H.G. , Flizar C.A. , Kalkkinen N. , Helin J.
      Eur. J. Biochem.259:829-840(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-120
    14. 14.
      "Interaction of HIV Tat and matrix metalloproteinase in HIV neuropathogenesis: a new host defense mechanism."
      Rumbaugh J. , Turchan-Cholewo J. , Galey D. , St Hillaire C. , Anderson C. , Conant K. , Nath A.
      FASEB J.20:1736-1738(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIV-1 TAT
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-360;MUTAGENESIS OF TYR-360
    16. 16.
      "Structure of the catalytic domain of human fibroblast collagenase complexed with an inhibitor."
      Borkakoti N. , Winkler F.K. , Williams D.H. , D'Arcy A. , Broadhurst M.J. , Brown P.A. , Johnson W.H. , Murray E.J.
      Nat. Struct. Biol.1:106-110(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 100-269
    17. 17.
      "Crystal structures of recombinant 19-kDa human fibroblast collagenase complexed to itself."
      Lovejoy B. , Hassell A.M. , Luther M.A. , Weigl D. , Jordan S.R.
      Biochemistry33:8207-8217(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 102-269
    18. 18.
      "Structure of the catalytic domain of fibroblast collagenase complexed with an inhibitor."
      Lovejoy B. , Cleasby A. , Hassell A.M. , Longley K. , Luther M.A. , Weigl D. , McGeehan G. , McElroy A.B. , Drewry D. , Lambert M.H. , Jordan S.R.
      Science263:375-377(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 102-269
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.56 ANGSTROMS) OF 101-269
    20. 20.
      "High-resolution solution structure of the inhibitor-free catalytic fragment of human fibroblast collagenase determined by multidimensional NMR."
      Moy F.J. , Chanda P.K. , Cosmi S. , Pisano M.R. , Urbano C. , Wilhelm J. , Powers R.
      Biochemistry37:1495-1504(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 101-269
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