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Index > Protein center > MMP2(Gene name) > Bovine
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  • MMP2 (Gene name),
  • 72 kDa type IV collagenase (Protein name ),  MMP2_BOVIN from NCBI database.
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  • Gene name:
    MMP2;
    Protein name:
    72 kDa type IV collagenase;
    Alternative:
    72 kDa gelatinase;Matrix metalloproteinase-2(MMP-2);
    Organism:
    Bovine (Bos taurus). 
    General Annotation
    Sub Unit:
    Interacts (via the C-terminal hemopexin-like domains-containing region) with the integrin alpha-V/beta-3; the interaction promotes vascular invasion in angiogenic vessels and melamoma cells. Interacts (via the C-terminal PEX domain) with TIMP2 (via the C-terminal); the interaction inhibits the degradation activity. Interacts with GSK3B.
    Function:
    PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrin alpha-v/beta-3 on the surface of blood vessels.
    Subcellular Location:
    Secreted extracellular space extracellular matrix Membrane Nucleus Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes.
    Protein Attributes:
    Sequence length:
    661
    Sequence:
    50:
    MTEARVSRGA | LAALLRALCA | LGCLLGRAAA | APSPIIKFPG | DVAPKTDKEL | 
    100:
    AVQYLNTFYG | CPKESCNLFV | LKDTLKKMQK | FFGLPQTGEL | DQSTIETMRK | 
    150:
    PRCGNPDVAN | YNFFPRKPKW | DKNQITYRII | GYTPDLDPQT | VDDAFARAFQ | 
    200:
    VWSDVTPLRF | SRIHDGEADI | MINFGRWEHG | DGYPFDGKDG | LLAHAFAPGP | 
    250:
    GVGGDSHFDD | DELRTLGEGQ | VVRVKYGNAD | GEYCKFPFRF | NGKEYTSCTD | 
    300:
    TGRSDGFLWC | STTYNFDKDG | KYGFCPHEAL | FTMGGNADGQ | PCKFPFRFQG | 
    350:
    TSYDSCTTEG | RTDGYRWCGT | TEDYDRDKEY | GFCPETAMST | VGGNSEGAPC | 
    400:
    VLPFTFLGNK | HESCTSAGRS | DGKLWCATTS | NYDDDRKWGF | CPDQGYSLFL | 
    450:
    VAAHEFGHAM | GLEHSQDPGA | LMAPIYTYTK | NFRLSHDDIQ | GIQELYGASP | 
    500:
    DIDTGTGPTP | TLGPVTPELC | KQDIVFDGIS | QIRGEIFFFK | DRFIWRTVTP | 
    550:
    RDKPTGPLLV | ATFWPELPEK | IDAVYEDPQE | EKAVFFAGNE | YWVYSASTLE | 
    600:
    RGYPKPLTSL | GLPPGVQKVD | AAFNWSKNKK | TYIFAGDKFW | RYNEVKKKMD | 
    650:
    PGFPKLIADA | WNAIPDNLDA | VVDLQGGGHS | YFFKGAYYLK | LENQSLKSVK | 
    661:
    FGSIKSDWLG | C
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    SMR:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Bovine 72 kDa type IV collagenase
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    E0100m
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    ELISA Kit for Bovine 72 kDa type IV collagenase
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    E0100h
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    ELISA Kit for Bovine 72 kDa type IV collagenase
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    E0100r
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    ELISA Kit for Bovine 72 kDa type IV collagenase
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    ELISA Kit for Bovine 72 kDa type IV collagenase
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    E0100c
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    ELISA Kit for Bovine 72 kDa type IV collagenase
    Cat.:
    E0100b
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    Packing:
    96T
    CLIA Kit for Bovine 72 kDa type IV collagenase
    MSDS:
    Please sign in first.
    CLIA Kit for Bovine 72 kDa type IV collagenase
    Cat.:
    U0100r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Bovine 72 kDa type IV collagenase
    Cat.:
    U0100h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Bovine 72 kDa type IV collagenase
    Cat.:
    U0100m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Bovine 72 kDa type IV collagenase
    Cat.:
    U0100b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine 72 kDa type IV collagenase
    Cat.:
    U0100c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Bovine 72 kDa type IV collagenase
    Polyclonal Antibody for Bovine 72 kDa type IV collagenase
    Cat.:
    P0100Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Bovine 72 kDa type IV collagenase
    Polyclonal Antibody for Bovine 72 kDa type IV collagenase
    Cat.:
    P0100Rb-m
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    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Bovine 72 kDa type IV collagenase
    Cat.:
    P0100Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Bovine 72 kDa type IV collagenase
    Monoclonal Antibody for Bovine 72 kDa type IV collagenase
    Monoclonal Antibody for Bovine 72 kDa type IV collagenase
    Monoclonal Antibody for Bovine 72 kDa type IV collagenase
    Monoclonal Antibody for Bovine 72 kDa type IV collagenase
    Monoclonal Antibody for Bovine 72 kDa type IV collagenase
    Monoclonal Antibody for Bovine 72 kDa type IV collagenase
    Protein for Bovine 72 kDa type IV collagenase
    Protein for Bovine 72 kDa type IV collagenase
    Protein for Bovine 72 kDa type IV collagenase
    Protein for Bovine 72 kDa type IV collagenase
    Protein for Bovine 72 kDa type IV collagenase
    Protein for Bovine 72 kDa type IV collagenase

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    References
    1. 1.
      "Molecular cloning and biological characterization of bovine matrix metalloprotease 2 (bMMP-2)."
      Yan L. , Zhang B. , Tsang P. , Fang J. , Yu Y. , Ingber D.E. , Moses M.A.
      Submitted (2000-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
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