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Index > Protein center > Faslg(Gene name) > Mouse
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  • Faslg (Gene name),
  • Tumor necrosis factor ligand superfamily member 6 (Protein name ),  TNFL6_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Faslg(Apt1lg1;Cd95l;Fasl;gld;Tnfsf6);
    Protein name:
    Tumor necrosis factor ligand superfamily member 6;
    Alternative:
    CD95 ligand(CD95-L);Fas antigen ligand(Fas ligand);
    CD:
    CD178;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homotrimer (Probable). Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1.
    Function:
    Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.
    Subcellular Location:
    Tumor necrosis factor ligand superfamily member 6, soluble form Secreted May be released into the extracellular fluid, probably by cleavage form the cell surface.
    Protein Attributes:
    Sequence length:
    279
    Sequence:
    50:
    MQQPMNYPCP | QIFWVDSSAT | SSWAPPGSVF | PCPSCGPRGP | DQRRPPPPPP | 
    100:
    PVSPLPPPSQ | PLPLPPLTPL | KKKDHNTNLW | LPVVFFMVLV | ALVGMGLGMY | 
    150:
    QLFHLQKELA | ELREFTNQSL | KVSSFEKQIA | NPSTPSEKKE | PRSVAHLTGN | 
    200:
    PHSRSIPLEW | EDTYGTALIS | GVKYKKGGLV | INETGLYFVY | SKVYFRGQSC | 
    250:
    NNQPLNHKVY | MRNSKYPEDL | VLMEEKRLNY | CTTGQIWAHS | SYLGAVFNLT | 
    279:
    SADHLYVNIS | QLSLINFEES | KTFFGLYKL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    String:
    Pfam:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Tumor necrosis factor ligand superfamily member 6
    Cat.:
    E0031m
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    96T
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    ELISA Kit for Mouse Tumor necrosis factor ligand superfamily member 6
    Cat.:
    E0031r
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    96T
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    ELISA Kit for Mouse Tumor necrosis factor ligand superfamily member 6
    Cat.:
    E0031h
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    ELISA Kit for Mouse Tumor necrosis factor ligand superfamily member 6
    Cat.:
    E0031p
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Tumor necrosis factor ligand superfamily member 6
    Cat.:
    U0031p
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Tumor necrosis factor ligand superfamily member 6
    Cat.:
    U0031h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Tumor necrosis factor ligand superfamily member 6
    Cat.:
    U0031m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Tumor necrosis factor ligand superfamily member 6
    Cat.:
    U0031r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Mouse Tumor necrosis factor ligand superfamily member 6
    Cat.:
    P0031Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Tumor necrosis factor ligand superfamily member 6
    Cat.:
    P0031Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Tumor necrosis factor ligand superfamily member 6
    Cat.:
    P0031Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Tumor necrosis factor ligand superfamily member 6
    Monoclonal Antibody for Mouse Tumor necrosis factor ligand superfamily member 6
    Monoclonal Antibody for Mouse Tumor necrosis factor ligand superfamily member 6
    Monoclonal Antibody for Mouse Tumor necrosis factor ligand superfamily member 6
    Monoclonal Antibody for Mouse Tumor necrosis factor ligand superfamily member 6
    Protein for Mouse Tumor necrosis factor ligand superfamily member 6
    Protein for Mouse Tumor necrosis factor ligand superfamily member 6
    Protein for Mouse Tumor necrosis factor ligand superfamily member 6
    Protein for Mouse Tumor necrosis factor ligand superfamily member 6

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand."
      Takahashi T. , Tanaka M. , Brannan C.I. , Jenkins N.A. , Copeland N.G. , Suda T. , Nagata S.
      Cell76:969-976(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM FASL)
    2. 2.
      "Comparative molecular modelling of the Fas-ligand and other members of the TNF family."
      Peitsch M.C. , Tschopp J.
      Mol. Immunol.32:761-772(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM FASL);3D-STRUCTURE MODELING
      strain: C57BL/6.
    3. 3.
      "The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster."
      Lynch D.H. , Watson M.L. , Alderson M.R. , Baum P.R. , Miller R.E. , Tough T. , Gibson M. , Davis-Smith T. , Smith C.A. , Hunter K.
      Immunity1:131-136(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM FASL)
    4. 4.
      "Mus musculus Balb/c Fas ligand differs from 129/SV Fas ligand in two amino acids."
      Fenner M.H. , Shioda T. , Isselbacher K.J.
      Submitted (1996-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM FASL)
      strain: BALB/c.
    5. 5.
      "Cloning and expression of a short Fas ligand: a new alternatively spliced product of the mouse Fas ligand gene."
      Ayroldi E. , D'Adamio F. , Zollo O. , Agostini M. , Moraca R. , Cannarile L. , Migliorati G. , Delfino D.V. , Riccardi C.
      Blood94:3456-3467(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM FASLS)
      strain: C3H.
      tissue: Spleen.
    6. 6.
      "Characterization of the non-functional Fas ligand of gld mice."
      Hahne M. , Peitsch M.C. , Irmler M. , Schroeter M. , Lowin B. , Rousseau M. , Bron C. , Renno T. , French L. , Tschopp J.
      Int. Immunol.7:1381-1386(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT GLD
    7. 7.
      "Polymorphism of murine Fas ligand that affects the biological activity."
      Kayagaki N. , Yamaguchi N. , Nagao F. , Matsuo S. , Maeda H. , Okumura K. , Yagita H.
      Proc. Natl. Acad. Sci. U.S.A.94:3914-3919(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALA-184 AND GLY-218
      strain: BALB/c.
      strain: C3H.
      strain: C57BL/6.
      strain: DBA/1.
      strain: DBA/2.
      strain: MRL.
      strain: NOD.
      strain: NZB.
      strain: NZW.
      strain: SJL.
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