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Index > Protein center > Fas(Gene name) > Mouse
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  • Fas (Gene name),
  • Tumor necrosis factor receptor superfamily member 6 (Protein name ),  TNR6_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Fas(Apt1;Tnfrsf6);
    Protein name:
    Tumor necrosis factor receptor superfamily member 6;
    Alternative:
    FASLG receptor;Apo-1 antigen;Apoptosis-mediating surface antigen FAS;
    CD:
    CD95;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Binds DAXX and RIPK1. Interacts with BRE and FEM1B (By similarity). Interacts with HIPK3. Part of a complex containing HIPK3 and FADD. Interacts with FADD.
    Function:
    Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    327
    Sequence:
    50:
    MLWIWAVLPL | VLAGSQLRVH | TQGTNSISES | LKLRRRVRET | DKNCSEGLYQ | 
    100:
    GGPFCCQPCQ | PGKKKVEDCK | MNGGTPTCAP | CTEGKEYMDK | NHYADKCRRC | 
    150:
    TLCDEEHGLE | VETNCTLTQN | TKCKCKPDFY | CDSPGCEHCV | RCASCEHGTL | 
    200:
    EPCTATSNTN | CRKQSPRNRL | WLLTILVLLI | PLVFIYRKYR | KRKCWKRRQD | 
    250:
    DPESRTSSRE | TIPMNASNLS | LSKYIPRIAE | DMTIQEAKKF | ARENNIKEGK | 
    300:
    IDEIMHDSIQ | DTAEQKVQLL | LCWYQSHGKS | DAYQDLIKGL | KKAECRRTLD | 
    327:
    KFQDMVQKDL | GKSTPDTGNE | NEGQCLE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    KEGG:
    SMR:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Tumor necrosis factor receptor superfamily member 6
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    E0030h
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    ELISA Kit for Mouse Tumor necrosis factor receptor superfamily member 6
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    E0030m
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    ELISA Kit for Mouse Tumor necrosis factor receptor superfamily member 6
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    E0030r
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    ELISA Kit for Mouse Tumor necrosis factor receptor superfamily member 6
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    E0030p
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    ELISA Kit for Mouse Tumor necrosis factor receptor superfamily member 6
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    E0030b
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    CLIA Kit for Mouse Tumor necrosis factor receptor superfamily member 6
    Cat.:
    U0030h
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    MSDS:
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    96T
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    CLIA Kit for Mouse Tumor necrosis factor receptor superfamily member 6
    Cat.:
    U0030m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Tumor necrosis factor receptor superfamily member 6
    Cat.:
    U0030p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Tumor necrosis factor receptor superfamily member 6
    Cat.:
    U0030r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Tumor necrosis factor receptor superfamily member 6
    Cat.:
    U0030b
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 6
    Polyclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 6
    Polyclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 6
    Cat.:
    P0030Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 6
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    P0030Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 6
    Cat.:
    P0030Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 6
    Monoclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 6
    Monoclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 6
    Monoclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 6
    Monoclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 6
    Protein for Mouse Tumor necrosis factor receptor superfamily member 6
    Protein for Mouse Tumor necrosis factor receptor superfamily member 6
    Protein for Mouse Tumor necrosis factor receptor superfamily member 6
    Protein for Mouse Tumor necrosis factor receptor superfamily member 6
    Protein for Mouse Tumor necrosis factor receptor superfamily member 6

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    References
    1. 1.
      "The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen."
      Watanabe-Fukunaga R. , Brannan C.I. , Itoh N. , Yonehara S. , Copeland N.G. , Jenkins N.A. , Nagata S.
      J. Immunol.148:1274-1279(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Role of a mutant fas receptor in a transgenic mouse."
      Koczan D. , Ibrahim S.M. , Thiesen H.J.
      Submitted (2000-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      strain: 129/Sv.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Kidney.
    4. 4.
      "A role for the Fas/FasL system in modulating genetic susceptibility to T-cell lymphoblastic lymphomas."
      Villa-Morales M. , Santos J. , Perez-Gomez E. , Quintanilla M. , Fernandez-Piqueras J.
      Cancer Res.67:5107-5116(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: C57BL/6J.
    5. 5.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Kidney.
    7. 7.
      "Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice."
      Adachi M. , Watanabe-Fukunaga R. , Nagata S.
      Proc. Natl. Acad. Sci. U.S.A.90:1756-1760(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-96
    8. 8.
      "Daxx, a novel Fas-binding protein that activates JNK and apoptosis."
      Yang X. , Khosravi-Far R. , Chang H.Y. , Baltimore D.
      Cell89:1067-1076(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DAXX
    9. 9.
      "FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits Fas-mediated Jun NH2-terminal kinase activation."
      Rochat-Steiner V. , Becker K. , Micheau O. , Schneider P. , Burns K. , Tschopp J.
      J. Exp. Med.192:1165-1174(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIPK3
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    11. 11.
      "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
      Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-220 AND THR-314;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      "p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks."
      Baeza-Raja B. , Eckel-Mahan K. , Zhang L. , Vagena E. , Tsigelny I.F. , Sassone-Corsi P. , Ptacek L.J. , Akassoglou K.
      J. Neurosci.33:10221-10234(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    13. 13.
      "Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis."
      Watanabe-Fukunaga R. , Brannan C.I. , Copeland N.G. , Jenkins N.A. , Nagata S.
      Nature356:314-317(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LPR ASN-246
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