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Index > Protein center > Txnip(Gene name) > Rat
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  • Txnip (Gene name),
  • Thioredoxin-interacting protein (Protein name ),  TXNIP_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Txnip(Vdup1);
    Protein name:
    Thioredoxin-interacting protein;
    Alternative:
    Vitamin D3 up-regulated protein 1;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1 (By similarity). Interacts (via C-terminus) with ITCH (via WW domains).
    Function:
    May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    394
    Sequence:
    50:
    MVMFKKIKSF | EVVFNDPEKV | YGSGEKVAGR | VTVEVCEVTR | VKAVRILACG | 
    100:
    VAKVLWMQGS | QQCKQTLDYL | RYEDTLLLED | QPTGENEMVI | MRPGNKYEYK | 
    150:
    FGFELPQGPL | GTSFKGKYGC | VDYWVKAFLD | RPSQPTQEAK | KNFEVMDLVD | 
    200:
    VNTPDLMAPV | SAKKEKKVSC | MFIPDGRVSV | SARIDRKGFC | EGDDISIHAD | 
    250:
    FENTCSRIVV | PKAAIVARHT | YLANGQTKVL | TQKLSSVRGN | HIISGTCASW | 
    300:
    RGKSLRVQKI | RPSILGCNIL | RVEYSLLIYV | SVPGSKKVIL | DLPLVIGSRS | 
    350:
    GLSSRTSSMA | SRTSSEMSWI | DLNIPDTPEA | PPCYMDVIPE | DHRLESPTTP | 
    394:
    LLDDVDDSQD | SPIFMYAPEF | QFMPPPTYTE | VDPCVLNNNN | NNVQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Thioredoxin-interacting protein
    Cat.:
    E1162h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat Thioredoxin-interacting protein
    Cat.:
    E1162p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Rat Thioredoxin-interacting protein
    Cat.:
    E1162m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Rat Thioredoxin-interacting protein
    Cat.:
    E1162r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Thioredoxin-interacting protein
    Cat.:
    U1162p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Thioredoxin-interacting protein
    Cat.:
    U1162m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Thioredoxin-interacting protein
    Cat.:
    U1162r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Thioredoxin-interacting protein
    Cat.:
    U1162h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Rat Thioredoxin-interacting protein
    Cat.:
    P1162Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Thioredoxin-interacting protein
    Polyclonal Antibody for Rat Thioredoxin-interacting protein
    Cat.:
    P1162Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Thioredoxin-interacting protein
    Cat.:
    P1162Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Thioredoxin-interacting protein
    Monoclonal Antibody for Rat Thioredoxin-interacting protein
    Monoclonal Antibody for Rat Thioredoxin-interacting protein
    Monoclonal Antibody for Rat Thioredoxin-interacting protein
    Protein for Rat Thioredoxin-interacting protein
    Protein for Rat Thioredoxin-interacting protein
    Protein for Rat Thioredoxin-interacting protein
    Protein for Rat Thioredoxin-interacting protein

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    Citations
    [1].
    Seok Kyo Seo, Hyo In Yang, Kyung Eun Lee, Hye Yeon Kim, SiHyun Cho, Young Sik Choi and Byung Seok Lee
    References
    1. 1.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Heart.
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