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Index > Protein center > VDR(Gene name) > Human
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  • VDR (Gene name),
  • Vitamin D3 receptor (Protein name ),  VDR_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    VDR(NR1I1);
    Protein name:
    Vitamin D3 receptor(VDR);
    Alternative:
    1,25-dihydroxyvitamin D3 receptor;Nuclear receptor subfamily 1 group I member 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding. Interacts with SMAD3. Interacts with MED1, NCOA1, NCOA2, NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts (in a ligand-dependent manner) with BAZ1B/WSTF.
    Function:
    Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    427
    Sequence:
    50:
    MEAMAASTSL | PDPGDFDRNV | PRICGVCGDR | ATGFHFNAMT | CEGCKGFFRR | 
    100:
    SMKRKALFTC | PFNGDCRITK | DNRRHCQACR | LKRCVDIGMM | KEFILTDEEV | 
    150:
    QRKREMILKR | KEEEALKDSL | RPKLSEEQQR | IIAILLDAHH | KTYDPTYSDF | 
    200:
    CQFRPPVRVN | DGGGSHPSRP | NSRHTPSFSG | DSSSSCSDHC | ITSSDMMDSS | 
    250:
    SFSNLDLSEE | DSDDPSVTLE | LSQLSMLPHL | ADLVSYSIQK | VIGFAKMIPG | 
    300:
    FRDLTSEDQI | VLLKSSAIEV | IMLRSNESFT | MDDMSWTCGN | QDYKYRVSDV | 
    350:
    TKAGHSLELI | EPLIKFQVGL | KKLNLHEEEH | VLLMAICIVS | PDRPGVQDAA | 
    400:
    LIEAIQDRLS | NTLQTYIRCR | HPPPGSHLLY | AKMIQKLADL | RSLNEEHSKQ | 
    427:
    YRCLSFQPEC | SMKLTPLVLE | VFGNEIS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    Pfam:
    UniGene:
    MIM:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human VDR
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    ELISA Kit for Human VDR
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    E0475h
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    96T
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    ELISA Kit for Human VDR
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    E0475m
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    ELISA Kit for Human VDR
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    E0475b
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    ELISA Kit for Human VDR
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    E0475p
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    ELISA Kit for Human VDR
    Cat.:
    E0475c
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human VDR
    Cat.:
    U0475c
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    CLIA Kit for Human VDR
    Cat.:
    U0475h
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    96T
    CLIA Kit for Human VDR
    Cat.:
    U0475b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human VDR
    Cat.:
    U0475r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human VDR
    Cat.:
    U0475m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human VDR
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    U0475p
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human VDR
    Cat.:
    P0475Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human VDR
    Polyclonal Antibody for Human VDR
    Polyclonal Antibody for Human VDR
    Polyclonal Antibody for Human VDR
    Cat.:
    P0475Rb-r
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    Packing:
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    Polyclonal Antibody for Human VDR
    Cat.:
    P0475Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human VDR
    Monoclonal Antibody for Human VDR
    Monoclonal Antibody for Human VDR
    Monoclonal Antibody for Human VDR
    Monoclonal Antibody for Human VDR
    Monoclonal Antibody for Human VDR
    Protein for Human VDR
    Protein for Human VDR
    Protein for Human VDR
    Protein for Human VDR
    Protein for Human VDR
    Protein for Human VDR

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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "A single receptor identical with that from intestine/T47D cells mediates the action of 1,25-dihydroxyvitamin D-3 in HL-60 cells."
      Goto H. , Chen K.S. , Prahl J.M. , Deluca H.F.
      Biochim. Biophys. Acta1132:103-108(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      Rae J.L. , Shepard A.R.
      Submitted (1997-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Lens epithelium.
    4. 4.
      "Structural organization of the human vitamin D receptor chromosomal gene and its promoter."
      Miyamoto K. , Kesterson R.A. , Yamamoto H. , Taketani Y. , Nishiwaki E. , Tatsumi S. , Inoue Y. , Morita K. , Takeda E. , Pike J.W.
      Mol. Endocrinol.11:1165-1179(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      NIEHS SNPs program
      Submitted (2003-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS VAL-230 AND ILE-362
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    7. 7.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Placenta.
    10. 10.
      "Vitamin D receptor expression in human lymphocytes. Signal requirements and characterization by western blots and DNA sequencing."
      Yu X.-P. , Mocharla H. , Hustmyer F.G. , Manolagas S.C.
      J. Biol. Chem.266:7588-7595(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-90 (ISOFORM 1/2)
      tissue: Peripheral blood.
    11. 11.
      "Promoter and 3'-untranslated-region haplotypes in the vitamin D receptor gene predispose to osteoporotic fracture: the Rotterdam study."
      Fang Y. , van Meurs J.B. , d'Alesio A. , Jhamai M. , Zhao H. , Rivadeneira F. , Hofman A. , van Leeuwen J.P. , Jehan F. , Pols H.A. , Uitterlinden A.G.
      Am. J. Hum. Genet.77:807-823(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 343-427
    12. 12.
      "Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300."
      Chen H. , Lin R.J. , Schiltz R.L. , Chakravarti D. , Nash A. , Nagy L. , Privalsky M.L. , Nakatani Y. , Evans R.M.
      Cell90:569-580(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCOA3
    13. 13.
      "Isolation and characterization of a novel coactivator protein, NCoA-62, involved in vitamin D-mediated transcription."
      Baudino T.A. , Kraichely D.M. , Jefcoat S.C. Jr. , Winchester S.K. , Partridge N.C. , Macdonald P.N.
      J. Biol. Chem.273:16434-16441(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNW1
    14. 14.
      "A new family of nuclear receptor coregulators that integrates nuclear receptor signaling through CBP."
      Mahajan M.A. , Samuels H.H.
      Mol. Cell. Biol.20:5048-5063(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCOA6
    15. 15.
      "Ligand-induced transrepression by VDR through association of WSTF with acetylated histones."
      Fujiki R. , Kim M.-S. , Sasaki Y. , Yoshimura K. , Kitagawa H. , Kato S.
      EMBO J.24:3881-3894(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH BAZ1B
    16. 16.
      "IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptibility."
      Nguyen H.H. , Takata R. , Akamatsu S. , Shigemizu D. , Tsunoda T. , Furihata M. , Takahashi A. , Kubo M. , Kamatani N. , Ogawa O. , Fujioka T. , Nakamura Y. , Nakagawa H.
      Hum. Mol. Genet.21:2076-2085(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IRX4
      tissue: Prostate.
    17. 17.
      "The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand."
      Rochel N. , Wurtz J.-M. , Mitschler A. , Klaholz B. , Moras D.
      Mol. Cell5:173-179(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 118-427 IN COMPLEX WITH DIHYDROXYVITAMIN D3;IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION
    18. 18.
      "Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands."
      Tocchini-Valentini G. , Rochel N. , Wurtz J.-M. , Mitschler A. , Moras D.
      Proc. Natl. Acad. Sci. U.S.A.98:5491-5496(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 118-427 IN COMPLEXES WITH VITAMIN D3 AND VITAMIN D3 ANALOGS
    19. 19.
      "Structural basis of VDR-DNA interactions on direct repeat response elements."
      Shaffer P.L. , Gewirth D.T.
      EMBO J.21:2242-2252(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 16-125 IN COMPLEX WITH DNA;MUTAGENESIS OF 61-PRO-PHE-62 AND HIS-75;SUBUNIT
    20. 20.
      "Crystal structures of the vitamin D nuclear receptor liganded with the vitamin D side chain analogues calcipotriol and seocalcitol, receptor agonists of clinical importance. Insights into a structural basis for the switching of calcipotriol to a receptor antagonist by further side chain modification."
      Tocchini-Valentini G. , Rochel N. , Wurtz J.-M. , Moras D.
      J. Med. Chem.47:1956-1961(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 188-427 IN COMPLEXES WITH VITAMIN D3 ANALOGS
    21. 21.
      "Structural analysis of RXR-VDR interactions on DR3 DNA."
      Shaffer P.L. , Gewirth D.T.
      J. Steroid Biochem. Mol. Biol.89:215-219(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 16-125 OF MUTANT ALA-61/ALA-62/ALA-75 IN COMPLEX WITH RXRA AND DNA;SUBUNIT
    22. 22.
      "Superagonistic action of 14-epi-analogs of 1,25-dihydroxyvitamin D explained by vitamin D receptor-coactivator interaction."
      Eelen G. , Verlinden L. , Rochel N. , Claessens F. , De Clercq P. , Vandewalle M. , Tocchini-Valentini G. , Moras D. , Bouillon R. , Verstuyf A.
      Mol. Pharmacol.67:1566-1573(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 188-427 IN COMPLEX WITH VITAMIN D3 ANALOG;IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;INTERACTION WITH NCOA1; NCOA2 AND MED1
    23. 23.
      "Probing a water channel near the A-ring of receptor-bound 1 alpha,25-dihydroxyvitamin D3 with selected 2 alpha-substituted analogues."
      Hourai S. , Fujishima T. , Kittaka A. , Suhara Y. , Takayama H. , Rochel N. , Moras D.
      J. Med. Chem.49:5199-5205(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 188-427 IN COMPLEXES WITH DIHYDROXYVITAMIN D3 AND VITAMIN D3 ANALOGS;FUNCTION
    24. 24.
      "Point mutations in the human vitamin D receptor gene associated with hypocalcemic rickets."
      Hughes M.R. , Malloy P.J. , Kieback D.G. , Kesterson R.A. , Pike J.W. , Feldman D. , O'Malley B.W.
      Science242:1702-1705(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VDDR2A ASP-33 AND GLN-73
    25. 25.
      "A new point mutation in the deoxyribonucleic acid-binding domain of the vitamin D receptor in a kindred with hereditary 1,25-dihydroxyvitamin D-resistant rickets."
      Yagi H. , Ozono K. , Miyake H. , Nagashima K. , Kuroume T. , Pike J.W.
      J. Clin. Endocrinol. Metab.76:509-512(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VDDR2A GLN-35
    26. 26.
      "A unique mutation in the vitamin D receptor gene in three Japanese patients with vitamin D-dependent rickets type II: utility of single-strand conformation polymorphism analysis for heterozygous carrier detection."
      Saijo T. , Ito M. , Takeda E. , Mahbubul Huq A.H.M. , Naito E. , Yokota I. , Sone T. , Pike J.W. , Kuroda Y.
      Am. J. Hum. Genet.49:668-673(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VDDR2A GLN-50
    27. 27.
      "A unique point mutation in the human vitamin D receptor chromosomal gene confers hereditary resistance to 1,25-dihydroxyvitamin D3."
      Sone T. , Marx S.J. , Liberman U.A. , Pike J.W.
      Mol. Endocrinol.4:623-631(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VDDR2A GLN-80
    28. 28.
      "Hereditary 1 alpha,25-dihydroxyvitamin D-resistant rickets resulting from a mutation in the vitamin D receptor deoxyribonucleic acid-binding domain."
      Malloy P.J. , Weisman Y. , Feldman D.
      J. Clin. Endocrinol. Metab.78:313-316(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VDDR2A GLN-80
    29. 29.
      "Two mutations in the hormone binding domain of the vitamin D receptor cause tissue resistance to 1,25 dihydroxyvitamin D3."
      Kristjansson K. , Rut A.R. , Hewison M. , O'Riordan J.L.H. , Hughes M.R.
      J. Clin. Invest.92:12-16(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VDDR2A LEU-274
    30. 30.
      "Two mutations causing vitamin D resistant rickets: modelling on the basis of steroid hormone receptor DNA-binding domain crystal structures."
      Rut A.R. , Hewison M. , Kristjansson K. , Luisi B. , Hughes M.R. , O'Riordan J.L.H.
      Clin. Endocrinol. (Oxf.)41:581-590(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VDDR2A GLU-45 AND ILE-47
    31. 31.
      "A novel mutation in the deoxyribonucleic acid-binding domain of the vitamin D receptor causes hereditary 1,25-dihydroxyvitamin D-resistant rickets."
      Lin U.-T. , Malloy P.J. , Sakati N. , Al-Ashwal A. , Feldman D.
      J. Clin. Endocrinol. Metab.81:2564-2569(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VDDR2A ASP-46
    32. 32.
      "Vitamin D receptors from patients with resistance to 1,25-dihydroxyvitamin D(3): point mutations confer reduced transactivation in response to ligand and impaired interaction with the retinoid X receptor heterodimeric partner."
      Whitfield G.K. , Selznick S.H. , Haussler C.A. , Hsieh J.-C. , Galligan M.A. , Jurutka P.W. , Thompson P.D. , Lee S.M. , Zerwekh J.E. , Haussler M.R.
      Mol. Endocrinol.10:1617-1631(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VDDR2A SER-314 AND CYS-391
    33. 33.
      "Hereditary vitamin D resistant rickets caused by a novel mutation in the vitamin D receptor that results in decreased affinity for hormone and cellular hyporesponsiveness."
      Malloy P.J. , Eccleshall T.R. , Gross C. , van Maldergem L. , Bouillon R. , Feldman D.
      J. Clin. Invest.99:297-304(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VDDR2A GLN-305
    34. 34.
      "Vitamin D receptor gene variants of BsmI, ApaI, TaqI, and FokI polymorphisms in spinal tuberculosis."
      Selvaraj P. , Kurian S.M. , Chandra G. , Reetha A.M. , Charles N. , Narayanan P.R.
      Clin. Genet.65:73-76(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN MYCOBACTERIUM TUBERCULOSIS SUSCEPTIBILITY
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