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Index > Protein center > VKORC1(Gene name) > Human
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  • VKORC1 (Gene name),
  • Vitamin K epoxide reductase complex subunit 1 (Protein name ),  VKOR1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    VKORC1(MSTP134;MSTP576;UNQ308/PRO351;VKOR);
    Protein name:
    Vitamin K epoxide reductase complex subunit 1;
    Alternative:
    Vitamin K1 2,3-epoxide reductase subunit 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K.
    Subcellular Location:
    Endoplasmic reticulum membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    163
    Sequence:
    50:
    MGSTWGSPGW | VRLALCLTGL | VLSLYALHVK | AARARDRDYR | ALCDVGTAIS | 
    100:
    CSRVFSSRWG | RGFGLVEHVL | GQDSILNQSN | SIFGCIFYTL | QLLLGCLRTR | 
    150:
    WASVLMLLSS | LVSLAGSVYL | AWILFFVLYD | FCIVCITTYA | INVSLMWLSF | 
    163:
    RKVQEPQGKA | KRH
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    Pfam:
    String:
    UniGene:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Vitamin K epoxide reductase complex subunit 1
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    E0505m
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    ELISA Kit for Human Vitamin K epoxide reductase complex subunit 1
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    ELISA Kit for Human Vitamin K epoxide reductase complex subunit 1
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    CLIA Kit for Human Vitamin K epoxide reductase complex subunit 1
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    CLIA Kit for Human Vitamin K epoxide reductase complex subunit 1
    Cat.:
    U0505m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Vitamin K epoxide reductase complex subunit 1
    Cat.:
    U0505r
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Vitamin K epoxide reductase complex subunit 1
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    Packing:
    96T
    Polyclonal Antibody for Human Vitamin K epoxide reductase complex subunit 1
    Polyclonal Antibody for Human Vitamin K epoxide reductase complex subunit 1
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    P0505Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Vitamin K epoxide reductase complex subunit 1
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    P0505Rb-r
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    Polyclonal Antibody for Human Vitamin K epoxide reductase complex subunit 1
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    P0505Rb-m
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Vitamin K epoxide reductase complex subunit 1
    Monoclonal Antibody for Human Vitamin K epoxide reductase complex subunit 1
    Monoclonal Antibody for Human Vitamin K epoxide reductase complex subunit 1
    Monoclonal Antibody for Human Vitamin K epoxide reductase complex subunit 1
    Protein for Human Vitamin K epoxide reductase complex subunit 1
    Protein for Human Vitamin K epoxide reductase complex subunit 1
    Protein for Human Vitamin K epoxide reductase complex subunit 1
    Protein for Human Vitamin K epoxide reductase complex subunit 1

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    References
    1. 1.
      "Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2."
      Rost S. , Fregin A. , Ivaskevicius V. , Conzelmann E. , Hoertnagel K. , Pelz H.-J. , Lappegard K. , Seifried E. , Scharrer I. , Tuddenham E.G.D. , Mueller C.R. , Strom T.M. , Oldenburg J.
      Nature427:537-541(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;VARIANTS CMRES LEU-29; ALA-45; GLY-58 AND ARG-128;VARIANT VKCFD2 TRP-98
      tissue: Kidney.
    2. 2.
      "Identification of the gene for vitamin K epoxide reductase."
      Li T. , Chang C.-Y. , Jin D.-Y. , Lin P.-J. , Khvorova A. , Stafford D.W.
      Nature427:541-544(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION
    3. 3.
      Liu B. , Qin B.M. , Sheng H. , Zhao B. , Liu Y.Q. , Wang X.Y. , Zhang Q. , Song L. , Lu H. , Xu H.S. , Zheng W.Y. , Gong J. , Wang Y.B. , Liu Y.Q. , Zhang C.N. , Shi Y. , Wang W. , Zhang Z. , more...
      Submitted (2003-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Aorta.
    4. 4.
      SeattleSNPs variation discovery resource
      Submitted (2004-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
      tissue: Brain.
    6. 6.
      "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
      Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Lung.
    9. 9.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 44-163 (ISOFORM 1)
    10. 10.
      "Vitamin K epoxide reductase: homology, active site and catalytic mechanism."
      Goodstadt L. , Ponting C.P.
      Trends Biochem. Sci.29:289-292(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POTENTIAL REDOX-ACTIVE SITE
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ARG-35; SER-56; LEU-120; LEU-128 AND TYR-139;CATALYTIC ACTIVITY;ENZYME REGULATION;FUNCTION
    12. 12.
      "Membrane topology mapping of vitamin K epoxide reductase by in vitro translation/cotranslocation."
      Tie J.-K. , Nicchitta C. , von Heijne G. , Stafford D.W.
      J. Biol. Chem.280:16410-16416(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TOPOLOGY;SUBCELLULAR LOCATION
    13. 13.
      "Site-directed mutagenesis of coumarin-type anticoagulant-sensitive VKORC1: evidence that highly conserved amino acids define structural requirements for enzymatic activity and inhibition by warfarin."
      Rost S. , Fregin A. , Hunerberg M. , Bevans C.G. , Muller C.R. , Oldenburg J.
      Thromb. Haemost.94:780-786(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;POTENTIAL REDOX-ACTIVE SITE;CATALYTIC ACTIVITY;ENZYME REGULATION;SUBCELLULAR LOCATION;MUTAGENESIS OF CYS-16; CYS-43; CYS-51; SER-57; CYS-85; CYS-96; ARG-98; CYS-132; CYS-135 AND TYR-139;CHARACTERIZATION OF VARIANT VKCFD2 TRP-98
    14. 14.
      "Vitamin K epoxide reductase prefers ER membrane-anchored thioredoxin-like redox partners."
      Schulman S. , Wang B. , Li W. , Rapoport T.A.
      Proc. Natl. Acad. Sci. U.S.A.107:15027-15032(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TOPOLOGY
    15. 15.
      "Novel insight into the mechanism of the vitamin K oxidoreductase (VKOR): electron relay through Cys43 and Cys51 reduces VKOR to allow vitamin K reduction and facilitation of vitamin K-dependent protein carboxylation."
      Rishavy M.A. , Usubalieva A. , Hallgren K.W. , Berkner K.L.
      J. Biol. Chem.286:7267-7278(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;FUNCTION;SUBCELLULAR LOCATION;TOPOLOGY;MUTAGENESIS OF CYS-43 AND CYS-51
    16. 16.
      "Human vitamin K epoxide reductase and its bacterial homologue have different membrane topologies and reaction mechanisms."
      Tie J.K. , Jin D.Y. , Stafford D.W.
      J. Biol. Chem.287:33945-33955(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TOPOLOGY;CATALYTIC ACTIVITY;ENZYME REGULATION;FUNCTION
    17. 17.
      "Membrane topology for human vitamin K epoxide reductase."
      Wu S. , Tie J.K. , Stafford D.W. , Pedersen L.G.
      J. Thromb. Haemost.12:112-114(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING
    18. 18.
      "Thirteen novel VKORC1 mutations associated with oral anticoagulant resistance: insights into improved patient diagnosis and treatment."
      Watzka M. , Geisen C. , Bevans C.G. , Sittinger K. , Spohn G. , Rost S. , Seifried E. , Muller C.R. , Oldenburg J.
      J. Thromb. Haemost.9:109-118(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CMRES THR-26; LEU-29; GLY-36; TYR-36; TRP-52; PHE-56; LEU-59; CYS-59; GLY-66; MET-66; ALA-71; SER-77; TYR-77; ASN-123 AND HIS-139
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