COL17A1 ELISA Kit for Human(Homo sapiens) | EIAab.comCOL17A1 ELISA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > COL17A1(Gene name) > Human

COL17A1 (Gene name),

Collagen alpha-1(XVII) chain (Protein name ), COHA1_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

COL17A1(BP180;BPAG2);

Protein name:

Collagen alpha-1(XVII) chain;

Alternative:

Bullous pemphigoid antigen 2;180 kDa bullous pemphigoid antigen 2;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homotrimers of alpha 1(XVII)chains. Interacts (via cytoplasmic region) with ITGB4 (via cytoplasmic region). Interacts (via cytoplasmic region) with DST isoform 3 (via N-terminus). Interacts (via N-terminus) with PLEC. Interacts (via cytoplasmic region) with DSP.

Function:

The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies.

Subcellular Location:

97 kDa linear IgA disease antigen Secreted extracellular space extracellular matrix basement membrane Localized in the lamina lucida beneath the hemidesmosomes.

Protein Attributes:

Sequence length:

1497

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1150:

1200:

1250:

1300:

1350:

1400:

1450:

1497:

PKGDRGPAGP | PGHPGPPGPR | GHKGEKGDKG | DQVYAGRRRR | RSIAVKP

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

String:

Q9UMD9

Pfam:

PF01391

KEGG:

hsa:1308

STRING:

9606.ENSP00000340937

UniGene:

Hs.117938

MIM:

113811

Uniprot:

Q9UMD9

FOR

ELISA Kit for Human Collagen alpha-1(XVII) chain

Cat.:

E0309h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human Collagen alpha-1(XVII) chain

Cat.:

E0309m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human Collagen alpha-1(XVII) chain

Cat.:

E0309d

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Human Collagen alpha-1(XVII) chain

Cat.:

E0309b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Human Collagen alpha-1(XVII) chain

Cat.:

E0309c

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Collagen alpha-1(XVII) chain

Cat.:

U0309c

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Collagen alpha-1(XVII) chain

Cat.:

U0309b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Collagen alpha-1(XVII) chain

Cat.:

U0309d

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Collagen alpha-1(XVII) chain

MSDS:

Please sign in first.

CLIA Kit for Human Collagen alpha-1(XVII) chain

Cat.:

U0309m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human Collagen alpha-1(XVII) chain

Cat.:

P0309Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Collagen alpha-1(XVII) chain

Cat.:

P0309Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Collagen alpha-1(XVII) chain

Protein for Human Collagen alpha-1(XVII) chain

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning and primary structural analysis of the bullous pemphigoid autoantigen, BP180."
Giudice G.J. , Emery D.J. , Diaz L.A.
J. Invest. Dermatol.99:243-250(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBCELLULAR LOCATION;VARIANT SER-428
tissue: Foreskin.
2.

"Cloning of the human type XVII collagen gene (COL17A1), and detection of novel mutations in generalized atrophic benign epidermolysis bullosa."
Gatalica B. , Pulkkinen L. , Li K. , Kuokkanen K. , Ryynaenen M. , McGrath J.A. , Uitto J.
Am. J. Hum. Genet.60:352-365(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1);VARIANTS ILE-231; THR-238; SER-428; VAL-703 AND GLY-1370
3.

"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-390;VARIANT MET-210
tissue: Pancreas.
5.

"Genomic organization of collagenous domains and chromosomal assignment of human 180-kDa bullous pemphigoid antigen-2, a novel collagen of stratified squamous epithelium."
Li K.H. , Sawamura D. , Giudice G.J. , Diaz L.A. , Mattei M.-G. , Chu M.-L. , Uitto J.
J. Biol. Chem.266:24064-24069(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 508-856;TISSUE SPECIFICITY
6.

"The 97-kDa (LABD97) and 120-kDa (LAD-1) fragments of bullous pemphigoid antigen 180/type XVII collagen have different N-termini."
Hirako Y. , Nishizawa Y. , Sitaru C. , Opitz A. , Marcus K. , Meyer H.E. , Butt E. , Owaribe K. , Zillikens D.
J. Invest. Dermatol.121:1554-1556(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 524-535
7.

"The 97 kDa linear IgA bullous disease antigen is identical to a portion of the extracellular domain of the 180 kDa bullous pemphigoid antigen, BPAg2."
Zone J.J. , Taylor T.B. , Meyer L.J. , Petersen M.J.
J. Invest. Dermatol.110:207-210(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 531-546; 554-565; 585-605; 647-666; 680-688; 689-703; 755-765; 842-860; 880-891; 1016-1028; 1062-1069; 1102-1108; 1134-1142; 1227-1247 AND 1248-1260
8.

"LAD-1, the linear IgA bullous dermatosis autoantigen, is a novel 120-kDa anchoring filament protein synthesized by epidermal cells."
Marinkovich M.P. , Taylor T.B. , Keene D.R. , Burgeson R.E. , Zone J.J.
J. Invest. Dermatol.106:734-738(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;FUNCTION;TISSUE SPECIFICITY
9.

Marinkovich M.P. , Taylor T.B. , Keene D.R. , Burgeson R.E. , Zone J.J.
J. Invest. Dermatol.106:1343-1343(1996)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
10.

"97-kDa linear IgA bullous dermatosis (LAD) antigen localizes to the lamina lucida of the epidermal basement membrane."
Ishiko A. , Shimizu H. , Masunaga T. , Hashimoto T. , Dmochowski M. , Wojnarowska F. , Bhogal B.S. , Black M.M. , Nishikawa T.
J. Invest. Dermatol.106:739-743(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
11.

"Evidence that the 180-kD bullous pemphigoid antigen is a transmembrane collagen, type XVII, in a triple-helical conformation and in type II transmembrane topography."
Limardo M. , Arffman A. , Aho S. , Utto J.
J. Invest. Dermatol.106:860-860(1996)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
12.

"Two forms of collagen XVII in keratinocytes. A full-length transmembrane protein and a soluble ectodomain."
Schaecke H. , Schumann H. , Hammami-Hauasli N. , Raghunath M. , Bruckner-Tuderman L.
J. Biol. Chem.273:25937-25943(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;PROTEOLYTIC PROCESSING;GLYCOSYLATION AT ASN-1421;DOMAINS
13.

"The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosome."
Hopkinson S.B. , Jones J.C.
Mol. Biol. Cell11:277-286(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DSP
14.

"Transmembrane collagen XVII, an epithelial adhesion protein, is shed from the cell surface by ADAMs."
Franzke C.-W. , Tasanen K. , Schaecke H. , Zhou Z. , Tryggvason K. , Mauch C. , Zigrino P. , Sunnarborg S. , Lee D.C. , Fahrenholz F. , Bruckner-Tuderman L.
EMBO J.21:5026-5035(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SHEDDING
15.

"Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly."
Koster J. , Geerts D. , Favre B. , Borradori L. , Sonnenberg A.
J. Cell Sci.116:387-399(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DSP; DST; ITGB4 AND PLEC;SUBCELLULAR LOCATION
16.

"Extracellular phosphorylation of collagen XVII by ecto-casein kinase 2 inhibits ectodomain shedding."
Zimina E.P. , Fritsch A. , Schermer B. , Bakulina A.Y. , Bashkurov M. , Benzing T. , Bruckner-Tuderman L.
J. Biol. Chem.282:22737-22746(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-544
17.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.

"Compound heterozygosity for a dominant glycine substitution and a recessive internal duplication mutation in the type XVII collagen gene results in junctional epidermolysis bullosa and abnormal dentition."
McGrath J.A. , Gatalica B. , Li K. , Dunnill M.G.S. , McMillan J.R. , Christiano A.M. , Eady R.A.J. , Uitto J.
Am. J. Pathol.148:1787-1796(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GABEB VAL-627
19.

"Three novel homozygous point mutations and a new polymorphism in the COL17A1 gene: relation to biological and clinical phenotypes of junctional epidermolysis bullosa."
Schumann H. , Hammami-Hauasli N. , Pulkkinen L. , Mauviel A. , Kuester W. , Luethi U. , Owaribe K. , Uitto J. , Bruckner-Tuderman L.
Am. J. Hum. Genet.60:1344-1353(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GABEB GLN-1303
20.

"Collagen XVII is destabilized by a glycine substitution mutation in the cell adhesion domain Col15."
Tasanen K. , Eble J.A. , Aumailley M. , Schumann H. , Baetge J. , Tu H. , Bruckner P. , Bruckner-Tuderman L.
J. Biol. Chem.275:3093-3099(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GABEB VAL-627
21.

"Hemizygosity for a glycine substitution in collagen XVII: unfolding and degradation of the ectodomain."
Tasanen K. , Floeth M. , Schumann H. , Bruckner-Tuderman L.
J. Invest. Dermatol.115:207-212(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GABEB ASP-633
22.

"A novel homozygous point mutation in the COL17A1 gene in a Chinese family with generalized atrophic benign epidermolysis bullosa."
Wu Y. , Li G. , Zhu X.
J. Dermatol. Sci.28:181-186(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GABEB CYS-265;VARIANT ILE-231

Product Feedback Wall

* Email:
*Comments: