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Index > Protein center > RNASE3(Gene name) > Human
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  • RNASE3 (Gene name),
  • Eosinophil cationic protein (Protein name ),  ECP_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    RNASE3(ECP;RNS3);
    Protein name:
    Eosinophil cationic protein(ECP);
    Alternative:
    Ribonuclease 3(RNase 3);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Function:
    Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity.
    Subcellular Location:
    Cytoplasmic granule Matrix of eosinophil's large specific granule.
    Protein Attributes:
    Sequence length:
    160
    Sequence:
    50:
    MVPKLFTSQI | CLLLLLGLMG | VEGSLHARPP | QFTRAQWFAI | QHISLNPPRC | 
    100:
    TIAMRAINNY | RWRCKNQNTF | LRTTFANVVN | VCGNQSIRCP | HNRTLNNCHR | 
    150:
    SRFRVPLLHC | DLINPGAQNI | SNCTYADRPG | RRFYVVACDN | RDPRDSPRYP | 
    160:
    VVPVHLDTTI | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    MIM:
    String:
    KEGG:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human ECP
    Cat.:
    E1758h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human ECP
    Cat.:
    E1758r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human ECP
    Cat.:
    E1758m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human ECP
    Cat.:
    U1758r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human ECP
    Cat.:
    U1758h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human ECP
    Cat.:
    U1758m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human ECP
    Cat.:
    P1758Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human ECP
    Cat.:
    P1758Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human ECP
    Cat.:
    P1758Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human ECP
    Monoclonal Antibody for Human ECP
    Monoclonal Antibody for Human ECP
    Protein for Human ECP
    Protein for Human ECP
    Protein for Human ECP

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Human eosinophil cationic protein. Molecular cloning of a cytotoxin and helminthotoxin with ribonuclease activity."
      Rosenberg H.F. , Ackerman S.J. , Tenen D.G.
      J. Exp. Med.170:163-176(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ARG-124
      tissue: Peripheral blood granulocyte.
    2. 2.
      "Structure and chromosome localization of the human eosinophil-derived neurotoxin and eosinophil cationic protein genes: evidence for intronless coding sequences in the ribonuclease gene superfamily."
      Hamann K.J. , Ten R.M. , Loegering D.A. , Jenkins R.B. , Heise M.T. , Schad C.R. , Pease L.R. , Gleich G.J. , Barker R.L.
      Genomics7:535-546(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ARG-124
      tissue: Fetal liver.
    3. 3.
      "Eosinophil cationic protein cDNA. Comparison with other toxic cationic proteins and ribonucleases."
      Barker R.L. , Loegering D.A. , Ten R.M. , Hamann K.J. , Pease L.R. , Gleich G.J.
      J. Immunol.143:952-955(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ARG-124
    4. 4.
      Simonsen C.C. , Kennedy J. , Comstock L. , Ashton N. , McGrogan M.
      Submitted (1990-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ARG-124
      tissue: Colon.
    5. 5.
      "Sequence variation at two eosinophil-associated ribonuclease loci in humans."
      Zhang J. , Rosenberg H.F.
      Genetics156:1949-1958(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ARG-124
    6. 6.
      "The DNA sequence and analysis of human chromosome 14."
      Heilig R. , Eckenberg R. , Petit J.-L. , Fonknechten N. , Da Silva C. , Cattolico L. , Levy M. , Barbe V. , De Berardinis V. , Ureta-Vidal A. , Pelletier E. , Vico V. , Anthouard V. , Rowen L. , Madan A. , Qin S. , Sun H. , Du H. , more...
      Nature421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ARG-124
    8. 8.
      "Identification of polymorphisms in the ECP gene. Relation to disease activity in Hodgkins lymphoma."
      Bystrom J. , Molin D. , Jonsson U.B. , Enblad G. , Sundstrom C. , Hogbom E. , Venge P.
      Submitted (2001-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 20-160;VARIANTS CYS-72 AND ARG-124
    9. 9.
      "Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: homology with ribonuclease."
      Gleich G.J. , Loegering D.A. , Bell M.P. , Checkel J.L. , Ackerman S.J. , McKean D.J.
      Proc. Natl. Acad. Sci. U.S.A.83:3146-3150(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 28-87
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 28-47;FUNCTION AS AN ANTIMICROBIAL PROTEIN
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NITRATION AT TYR-60
    12. 12.
      "Bactericidal and membrane disruption activities of the eosinophil cationic protein are largely retained in an N-terminal fragment."
      Torrent M. , de la Torre B.G. , Nogues V.M. , Andreu D. , Boix E.
      Biochem. J.421:425-434(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH LPS; LTA AND LIPID BILAYERS
    13. 13.
      "Eosinophil cationic protein aggregation: identification of an N-terminus amyloid prone region."
      Torrent M. , Odorizzi F. , Nogues M.V. , Boix E.
      Biomacromolecules11:1983-1990(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IN VITRO FORMATION OF AMYLOID-LIKE AGGREGATES;MUTAGENESIS OF ILE-40
    14. 14.
      "Crystal structure of eosinophil cationic protein at 2.4 A resolution."
      Boix E. , Leonidas D.D. , Nikolovski Z. , Nogues M.V. , Cuchillo C.M. , Acharya K.R.
      Biochemistry38:16794-16801(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 28-160
    15. 15.
      "Three-dimensional crystal structure of human eosinophil cationic protein (RNase 3) at 1.75 A resolution."
      Mallorqui-Fernandez G. , Pous J. , Peracaula R. , Aymami J. , Maeda T. , Tada H. , Yamada H. , Seno M. , de Llorens R. , Gomis-Rueth F.-X. , Coll M.
      J. Mol. Biol.300:1297-1307(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 28-160
    16. 16.
      "The crystal structure of eosinophil cationic protein in complex with 2',5'-ADP at 2.0 A resolution reveals the details of the ribonucleolytic active site."
      Mohan C.G. , Boix E. , Evans H.R. , Nikolovski Z. , Nogues M.V. , Cuchillo C.M. , Acharya K.R.
      Biochemistry41:12100-12106(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 28-160
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