EFNA1 ELISA Kit for Human(Homo sapiens) | EIAab.comEFNA1 ELISA Kit for Human(Homo sapiens)

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EFNA1 (Gene name),

Ephrin-A1 (Protein name ), EFNA1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

EFNA1(EPLG1;LERK1;TNFAIP4);

Protein name:

Ephrin-A1;

Alternative:

Immediate early response protein B61;EPH-related receptor tyrosine kinase ligand 1(LERK-1);Tumor necrosis factor alpha-induced protein 4(TNF alpha-induced protein 4);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer. Homodimer. Forms heterodimers with EPHA2. Binds to the receptor tyrosine kinases EPHA2, EPHA3, EPHA4, EPHA5, EPHA6 and EPHA7. Also binds with low affinity to EPHA1.

Function:

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.

Subcellular Location:

Ephrin-A1, secreted form Secreted

Protein Attributes:

Sequence length:

205

Sequence:

50:

100:

150:

200:

205:

LLQTP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:1942

Pfam:

PF00812

String:

P20827

UniGene:

Hs.516664

STRING:

9606.ENSP00000357392

SMR:

P20827

MIM:

191164

Uniprot:

P20827

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ELISA Kit for Human Ephrin-A1

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E1422h

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96T

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ELISA Kit for Human Ephrin-A1

Cat.:

E1422m

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96T

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ELISA Kit for Human Ephrin-A1

Cat.:

E1422p

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96T

ELISA Kit for Human Ephrin-A1

Cat.:

E1422r

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96T

ELISA Kit for Human Ephrin-A1

Cat.:

E1422b

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96T

CLIA Kit for Human Ephrin-A1

Cat.:

U1422h

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96T

CLIA Kit for Human Ephrin-A1

Cat.:

U1422r

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96T

CLIA Kit for Human Ephrin-A1

Cat.:

U1422m

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Packing:

96T

CLIA Kit for Human Ephrin-A1

Cat.:

U1422b

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96T

CLIA Kit for Human Ephrin-A1

Cat.:

U1422p

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96T

Polyclonal Antibody for Human Ephrin-A1

Cat.:

P1422Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Ephrin-A1

Cat.:

P1422Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Ephrin-A1

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P1422Rb-m

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Monoclonal Antibody for Human Ephrin-A1

Protein for Human Ephrin-A1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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Citations

[1].

"Molecular targeting of malignant glioma cells with an EphA2-specific immunotoxin delivered by human bone marrow-derived mesenchymal stem cells"

X Sun, Z Xu, Y Ke, et al.

From:Cancer Letters

References

1.

"A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein."
Holzman L.B. , Marks R.M. , Dixit V.M.
Mol. Cell. Biol.10:5830-5838(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT VAL-159
2.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT VAL-159
3.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT VAL-159
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT VAL-159
tissue: Liver.
6.

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z. , Henzel W.J.
Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 19-33
7.

"Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins."
Kozlosky C.J. , Maraskovsky E. , McGrew J.T. , Vanden Bos T. , Teepe M. , Lyman S.D. , Srinivasan S. , Fletcher F.A. , Gayle R.B. III , Cerretti D.P. , Beckmann M.P.
Oncogene10:299-306(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GPI-ANCHOR
8.

"Ephrin-A1 is a negative regulator in glioma through down-regulation of EphA2 and FAK."
Liu D.-P. , Wang Y. , Koeffler H.P. , Xie D.
Int. J. Oncol.30:865-871(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
9.

"Soluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptor."
Wykosky J. , Palma E. , Gibo D.M. , Ringler S. , Turner C.P. , Debinski W.
Oncogene27:7260-7273(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;SUBCELLULAR LOCATION;PROTEOLYTIC CLEAVAGE
10.

"Biological and structural characterization of glycosylation on ephrin-A1, a preferred ligand for EphA2 receptor tyrosine kinase."
Ferluga S. , Hantgan R. , Goldgur Y. , Himanen J.P. , Nikolov D.B. , Debinski W.
J. Biol. Chem.288:18448-18457(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-26;INTERACTION WITH EPHA2
11.

"Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex."
Himanen J.P. , Goldgur Y. , Miao H. , Myshkin E. , Guo H. , Buck M. , Nguyen M. , Rajashankar K.R. , Wang B. , Nikolov D.B.
EMBO Rep.10:722-728(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 19-147 IN COMPLEX WITH EPHA2;SUBUNIT;DISULFIDE BOND;GLYCOSYLATION AT ASN-26
12.

"Architecture of Eph receptor clusters."
Himanen J.P. , Yermekbayeva L. , Janes P.W. , Walker J.R. , Xu K. , Atapattu L. , Rajashankar K.R. , Mensinga A. , Lackmann M. , Nikolov D.B. , Dhe-Paganon S.
Proc. Natl. Acad. Sci. U.S.A.107:10860-10865(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 19-171 IN COMPLEX WITH EPHA2;SUBUNIT;GLYCOSYLATION AT ASN-26;DISULFIDE BONDS

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