EGFR ELISA Kit for Human(Homo sapiens) | EIAab.comEGFR ELISA Kit for Human(Homo sapiens)

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EGFR (Gene name),

Epidermal growth factor receptor (Protein name ), EGFR_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

EGFR(ERBB1;ERBB1;HER1);

Protein name:

Epidermal growth factor receptor;

Alternative:

Receptor tyrosine-protein kinase erbB-1;Proto-oncogene c-ErbB-1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

EGF binding triggers dimerization of the receptor and promotes autophosphorylation. The activate receptor dimer binds one EGF molecule. Heterodimer with ERBB2. Interacts with ERRFI1. Interaction with ERRFI1 inhibits dimerization of the kinase domain and autophosphorylation. Binds RIPK1. Interacts (via autophosphorylated C-terminal tail) with CBL. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. Interacts (autophosphorylated form) with PIK3C2B; the interaction may be indirect. Interacts with PELP1. Binds MUC1. Interacts with AP2M1. Interacts with GAB2. Interacts with COPG, upon EGF treatment; interaction is essential for regulation of EGF-dependent nuclear transport of EGFR by retrograde trafficking from the Golgi to the ER. Interacts with TNK2; this interaction is dependent on EGF stimulation and kinase activity of EGFR. Interacts with FER.

Function:

Isoform 2 may act as an antagonist of EGF action.

Subcellular Location:

Isoform 2 Secreted

Protein Attributes:

Sequence length:

1210

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1150:

1200:

1210:

APQSSEFIGA |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:1956

UniGene:

Hs.488293

Pfam:

PF00757

MIM:

131550

String:

P00533

SMR:

P00533

Uniprot:

P00533

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ELISA Kit for Human Epidermal growth factor receptor

Cat.:

E0757h

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96T

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ELISA Kit for Human Epidermal growth factor receptor

Cat.:

E0757m

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96T

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ELISA Kit for Human Epidermal growth factor receptor

Cat.:

E0757c

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96T

CLIA Kit for Human Epidermal growth factor receptor

Cat.:

U0757c

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Packing:

96T

CLIA Kit for Human Epidermal growth factor receptor

Cat.:

U0757h

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Packing:

96T

CLIA Kit for Human Epidermal growth factor receptor

Cat.:

U0757m

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96T

Polyclonal Antibody for Human Epidermal growth factor receptor

Cat.:

P0757Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Epidermal growth factor receptor

Cat.:

P0757Rb-h

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Monoclonal Antibody for Human Epidermal growth factor receptor

Protein for Human Epidermal growth factor receptor

R&D Technical Data

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Precision

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Recovery

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Linearity

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Citations

[1].

"Cetuximab Combination with Chemotherapy in Advanced Non-Small Cell Lung Cancer"

J Duan, L Yang, J Wang, et al.

From:www.springerlink.com/Chin J Cancer Res

References

1.

"Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells."
Ullrich A. , Coussens L. , Hayflick J.S. , Dull T.J. , Gray A. , Tam A.W. , Lee J. , Yarden Y. , Libermann T.A. , Schlessinger J. , Downward J. , Mayes E.L.V. , Whittle N. , Waterfield M.D. , Seeburg P.H.
Nature309:418-425(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Possible role of variant RNA transcripts in the regulation of epidermal growth factor receptor expression in human placenta."
Ilekis J.V. , Stark B.C. , Scoccia B.
Mol. Reprod. Dev.41:149-156(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Placenta.
3.

"A 1.8 kb alternative transcript from the human epidermal growth factor receptor gene encodes a truncated form of the receptor."
Reiter J.L. , Maihle N.J.
Nucleic Acids Res.24:4050-4056(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2)
tissue: Placenta.
4.

"Expression of a truncated epidermal growth factor receptor-like protein (TEGFR) in ovarian cancer."
Ilekis J.V. , Gariti J. , Niederberger C. , Scoccia B.
Gynecol. Oncol.65:36-41(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Placenta.
5.

"Comparative genomic sequence analysis and isolation of human and mouse alternative EGFR transcripts encoding truncated receptor isoforms."
Reiter J.L. , Threadgill D.W. , Eley G.D. , Strunk K.E. , Danielsen A.J. , Schehl Sinclair C. , Pearsall R.S. , Green P.J. , Yee D. , Lampland A.L. , Balasubramaniam S. , Crossley T.D. , Magnuson T.R. , James C.D. , Maihle N.J.
Genomics71:1-20(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 3 AND 4)
tissue: Placenta.
6.

"Cloning of the cDNA for a short EGF receptor from human placenta."
Xu L. , Hong A. , He X.
Submitted (2004-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
7.

NIEHS SNPs program
Submitted (2004-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLN-98; ARG-266; LYS-521; ILE-674; GLY-962 AND PRO-988
8.

"Human and mouse alternative EGFR transcripts encoding only the extracellular domain of the receptor."
Reiter J.L. , Threadgill D.W. , Danielsen A.J. , Schehl C.M. , Lampland A.L. , Balasubramaniam S. , Crossley T.O. , Magnuson T.R. , Maihle N.J.
Submitted (1999-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 575-687
9.

"Expression cloning of human EGF receptor complementary DNA: gene amplification and three related messenger RNA products in A431 cells."
Lin C.R. , Chen W.S. , Kruiger W. , Stolarsky L.S. , Weber W. , Evans R.M. , Verma I.M. , Gill G.N. , Rosenfeld M.G.
Science224:843-848(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 713-924
10.

"Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells."
Xu Y.H. , Ishii S. , Clark A.J.L. , Sullivan M. , Wilson R.K. , Ma D.P. , Roe B.A. , Merlino G.T. , Pastan I.
Nature309:806-810(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 150-962
11.

"Isolation of an evolutionarily conserved epidermal growth factor receptor cDNA from human A431 carcinoma cells."
Simmen F.A. , Gope M.L. , Schulz T.Z. , Wright D.A. , Carpenter G. , O'Malley B.W.
Biochem. Biophys. Res. Commun.124:125-132(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1028-1210
12.

"The human EGF receptor gene: structure of the 110 kb locus and identification of sequences regulating its transcription."
Haley J.D. , Whittle N. , Bennett P. , Kinchington D. , Ullrich A. , Waterfield M.D.
Oncogene Res.1:375-396(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-29
13.

"Contributory effects of de novo transcription and premature transcript termination in the regulation of human epidermal growth factor receptor proto-oncogene RNA synthesis."
Haley J.D. , Waterfield M.D.
J. Biol. Chem.266:1746-1753(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-29
14.

"Characterization and sequence of the promoter region of the human epidermal growth factor receptor gene."
Ishii S. , Xu Y.H. , Stratton R.H. , Roe B.A. , Merlino G.T. , Pastan I.
Proc. Natl. Acad. Sci. U.S.A.82:4920-4924(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-29
15.

"Production of an epidermal growth factor receptor-related protein."
Weber W. , Gill G.N. , Spiess J.
Science224:294-297(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-49
16.

Kohda D.
Submitted (1997-09) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 540
17.

"Epidermal growth factor receptor threonine and serine residues phosphorylated in vivo."
Heisermann G.J. , Gill G.N.
J. Biol. Chem.263:13152-13158(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 687-705; 986-998; 1000-1023; 1026-1030 AND 1068-1077;PHOSPHORYLATION AT THR-693; SER-695; SER-1070 AND SER-1071
18.

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z. , Henzel W.J.
Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 25-39
19.

"Identification of residues in the nucleotide binding site of the epidermal growth factor receptor/kinase."
Russo M.W. , Lukas T.J. , Cohen S. , Staros J.V.
J. Biol. Chem.260:5205-5208(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 740-744 AND 746-747
20.

"Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain."
Huang F. , Kirkpatrick D. , Jiang X. , Gygi S.P. , Sorkin A.
Mol. Cell21:737-748(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 861-875 AND 914-932;UBIQUITINATION AT LYS-716; LYS-737; LYS-754; LYS-867; LYS-929 AND LYS-970;IDENTIFICATION BY MASS SPECTROMETRY
21.

"Disulfide bond structure of human epidermal growth factor receptor."
Abe Y. , Odaka M. , Inagaki F. , Lax I. , Schlessinger J. , Kohda D.
J. Biol. Chem.273:11150-11157(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;DISULFIDE BONDS
22.

"ATP-stimulated interaction between epidermal growth factor receptor and supercoiled DNA."
Mroczkowski B. , Mosig G. , Cohen S.
Nature309:270-273(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RECEPTOR ACTIVITY
23.

"Receptors for epidermal growth factor and other polypeptide mitogens."
Carpenter G.
Annu. Rev. Biochem.56:881-914(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
24.

"Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation."
Chen W.S. , Lazar C.S. , Lund K.A. , Welsh J.B. , Chang C.P. , Walton G.M. , Der C.J. , Wiley H.S. , Gill G.N. , Rosenfeld M.G.
Cell59:33-43(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: LIGAND-BINDING
25.

"All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor."
Margolis B.L. , Lax I. , Kris R. , Dombalagian M. , Honegger A.M. , Howk R. , Givol D. , Ullrich A. , Schlessinger J.
J. Biol. Chem.264:10667-10671(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-1110
26.

"Amphiregulin induces tyrosine phosphorylation of the epidermal growth factor receptor and p185erbB2. Evidence that amphiregulin acts exclusively through the epidermal growth factor receptor at the surface of human epithelial cells."
Johnson G.R. , Kannan B. , Shoyab M. , Stromberg K.
J. Biol. Chem.268:2924-2931(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF AMPHIREGULIN AS LIGAND
27.

"Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor."
Galcheva-Gargova Z. , Konstantinov K.N. , Wu I.-H. , Klier F.G. , Barrett T. , Davis R.J.
Science272:1797-1802(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZPR1
28.

"Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells."
Gangwani L. , Mikrut M. , Galcheva-Gargova Z. , Davis R.J.
J. Cell Biol.143:1471-1484(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZPR1
29.

"Cell-type specific phosphorylation of threonines T654 and T669 by PKD defines the signal capacity of the EGF receptor."
Bagowski C.P. , Stein-Gerlach M. , Choidas A. , Ullrich A.
EMBO J.18:5567-5576(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-678 AND THR-693
30.

"Recombinant human betacellulin. Molecular structure, biological activities, and receptor interaction."
Watanabe T. , Shintani A. , Nakata M. , Shing Y. , Folkman J. , Igarashi K. , Sasada R.
J. Biol. Chem.269:9966-9973(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF BETACELLULIN/BTC AS LIGAND
31.

"Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation."
Galisteo M.L. , Dikic I. , Batzer A.G. , Langdon W.Y. , Schlessinger J.
J. Biol. Chem.270:20242-20245(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF CBL;INTERACTION WITH CBL
32.

"Analysis of the glycosylation patterns of the extracellular domain of the epidermal growth factor receptor expressed in Chinese hamster ovary fibroblasts."
Smith K.D. , Davies M.J. , Bailey D. , Renouf D.V. , Hounsell E.F.
Growth Factors13:121-132(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-128; ASN-175; ASN-413; ASN-444 AND ASN-528
33.

"Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4."
Komurasaki T. , Toyoda H. , Uchida D. , Morimoto S.
Oncogene15:2841-2848(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF EPIREGULIN/EREG AS LIGAND
34.

"Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase."
Tiganis T. , Bennett A.M. , Ravichandran K.S. , Tonks N.K.
Mol. Cell. Biol.18:1622-1634(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;DEPHOSPHORYLATION BY PTPN1 AND PTPN2
35.

"Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant mu2 subunit and its effects on endocytosis."
Nesterov A. , Carter R.E. , Sorkina T. , Gill G.N. , Sorkin A.
EMBO J.18:2489-2499(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AP2M1
36.

"Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck."
Braverman L.E. , Quilliam L.A.
J. Biol. Chem.274:5542-5549(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB2; NCK1 AND NCK2
37.

"Characterization of the N-oligosaccharides attached to the atypical Asn-X-Cys sequence of recombinant human epidermal growth factor receptor."
Sato C. , Kim J.-H. , Abe Y. , Saito K. , Yokoyama S. , Kohda D.
J. Biochem.127:65-72(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-56; ASN-352; ASN-361; ASN-568 AND ASN-603
38.

"RGS16 function is regulated by epidermal growth factor receptor-mediated tyrosine phosphorylation."
Derrien A. , Druey K.M.
J. Biol. Chem.276:48532-48538(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF RGS16
39.

"Characterization of glycosylation sites of the epidermal growth factor receptor."
Zhen Y. , Caprioli R.M. , Staros J.V.
Biochemistry42:5478-5492(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-56; ASN-128; ASN-175; ASN-196; ASN-352; ASN-361; ASN-413; ASN-444; ASN-528; ASN-568; ASN-603 AND ASN-623
40.

"Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor."
Shao H. , Cheng H.Y. , Cook R.G. , Tweardy D.J.
Cancer Res.63:3923-3930(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL PROLIFERATION;INTERACTION WITH STAT3;PHOSPHORYLATION AT TYR-1092 AND TYR-1110
41.

"LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation."
Gur G. , Rubin C. , Katz M. , Amit I. , Citri A. , Nilsson J. , Amariglio N. , Henriksson R. , Rechavi G. , Hedman H. , Wides R. , Yarden Y.
EMBO J.23:3270-3281(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;INTERACTION WITH LRIG1
42.

"Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors."
Arcaro A. , Zvelebil M.J. , Wallasch C. , Ullrich A. , Waterfield M.D. , Domin J.
Mol. Cell. Biol.20:3817-3830(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN EGFR SIGNALING;IDENTIFICATION IN A COMPLEX WITH PIK3C2A AND ERBB2;IDENTIFICATION IN A COMPLEX WITH PIK3C2B AND ERBB2;INTERACTION WITH PIK3C2B;MUTAGENESIS OF TYR-1016; TYR-1092; TYR-1110; TYR-1172 AND TYR-1197
43.

"The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome."
Habib A.A. , Chatterjee S. , Park S.-K. , Ratan R.R. , Lefebvre S. , Vartanian T.
J. Biol. Chem.276:8865-8874(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN NF-KAPPA-B ACTIVATION;INTERACTION WITH RIPK1
44.

"The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin."
Li Y. , Ren J. , Yu W. , Li Q. , Kuwahara H. , Yin L. , Carraway K.L. III , Kufe D.
J. Biol. Chem.276:35239-35242(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF MUC1;INTERACTION WITH MUC1
45.

"Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling."
Kario E. , Marmor M.D. , Adamsky K. , Citri A. , Amit I. , Amariglio N. , Rechavi G. , Yarden Y.
J. Biol. Chem.280:7038-7048(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;INTERACTION WITH SOCS5
46.

"Epigen, the last ligand of ErbB receptors, reveals intricate relationships between affinity and mitogenicity."
Kochupurakkal B.S. , Harari D. , Di-Segni A. , Maik-Rachline G. , Lyass L. , Gur G. , Kerber G. , Citri A. , Lavi S. , Eilam R. , Chalifa-Caspi V. , Eshhar Z. , Pikarsky E. , Pinkas-Kramarski R. , Bacus S.S. , Yarden Y.
J. Biol. Chem.280:8503-8512(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF EPIGEN/EPGN AS A LIGAND
47.

"Extended Range Proteomic Analysis (ERPA): a new and sensitive LC-MS platform for high sequence coverage of complex proteins with extensive post-translational modifications-comprehensive analysis of beta-casein and epidermal growth factor receptor (EGFR)."
Wu S.L. , Kim J. , Hancock W.S. , Karger B.
J. Proteome Res.4:1155-1170(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-56; ASN-128; ASN-175; ASN-196; ASN-352; ASN-361; ASN-413; ASN-444; ASN-528; ASN-568 AND ASN-603;PHOSPHORYLATION AT THR-693; SER-991 AND SER-1026;IDENTIFICATION BY MASS SPECTROMETRY
48.

"Functional implications of altered subcellular localization of PELP1 in breast cancer cells."
Vadlamudi R.K. , Manavathi B. , Balasenthil S. , Nair S.S. , Yang Z. , Sahin A.A. , Kumar R.
Cancer Res.65:7724-7732(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PELP1
49.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1172 AND TYR-1197;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
50.

"Tyrosine phosphorylation controls PCNA function through protein stability."
Wang S.C. , Nakajima Y. , Yu Y.L. , Xia W. , Chen C.T. , Yang C.C. , McIntush E.W. , Li L.Y. , Hawke D.H. , Kobayashi R. , Hung M.C.
Nat. Cell Biol.8:1359-1368(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL PROLIFERATION;FUNCTION IN PCNA PHOSPHORYLATION;INTERACTION WITH PCNA;SUBCELLULAR LOCATION
51.

"Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia."
Groenestege W.M.T. , Thebault S. , van der Wijst J. , van den Berg D. , Janssen R. , Tejpar S. , van den Heuvel L.P. , van Cutsem E. , Hoenderop J.G. , Knoers N.V. , Bindels R.J.
J. Clin. Invest.117:2260-2267(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
52.

"Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation."
Shen F. , Lin Q. , Gu Y. , Childress C. , Yang W.
Mol. Biol. Cell18:732-742(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TNF2;SUBCELLULAR LOCATION
53.

"Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking."
Nonis D. , Schmidt M.H. , van de Loo S. , Eich F. , Dikic I. , Nowock J. , Auburger G.
Cell. Signal.20:1725-1739(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATX2
54.

"Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein."
Brummer T. , Larance M. , Herrera Abreu M.T. , Lyons R.J. , Timpson P. , Emmerich C.H. , Fleuren E.D.G. , Lehrbach G.M. , Schramek D. , Guilhaus M. , James D.E. , Daly R.J.
EMBO J.27:2305-2316(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GAB2
55.

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T. , Yi W. , Lu B. , Park S.K. , Xu T. , Lee J.-D. , Yates J.R. III
J. Proteome Res.7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
56.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-693; SER-695; SER-1064; SER-1081; SER-1166 AND TYR-1197;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
57.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-991; SER-995; TYR-998; SER-1039; THR-1041; SER-1042; SER-1064 AND SER-1166;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
58.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
59.

"An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis."
Tarcic G. , Boguslavsky S.K. , Wakim J. , Kiuchi T. , Liu A. , Reinitz F. , Nathanson D. , Takahashi T. , Mischel P.S. , Ng T. , Yarden Y.
Curr. Biol.19:1788-1798(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION BY PTPRJ AND PTPRK;PHOSPHORYLATION AT TYR-1197;DEPHOSPHORYLATION BY PTPRJ;SUBCELLULAR LOCATION;INTERACTION WITH CBL AND GRB2
60.

"GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling."
Tashiro K. , Tsunematsu T. , Okubo H. , Ohta T. , Sano E. , Yamauchi E. , Taniguchi H. , Konishi H.
J. Biol. Chem.284:20206-20214(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GAREM
61.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-352; ASN-413 AND ASN-568
tissue: Liver.
62.

"Large-scale proteomics analysis of the human kinome."
Oppermann F.S. , Gnad F. , Olsen J.V. , Hornberger R. , Greff Z. , Keri G. , Mann M. , Daub H.
Mol. Cell. Proteomics8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
63.

"G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells."
Vivacqua A. , Lappano R. , De Marco P. , Sisci D. , Aquila S. , De Amicis F. , Fuqua S.A. , Ando S. , Maggiolini M.
Mol. Endocrinol.23:1815-1826(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GPER1
64.

"COPI-mediated retrograde trafficking from the Golgi to the ER regulates EGFR nuclear transport."
Wang Y.N. , Wang H. , Yamaguchi H. , Lee H.J. , Lee H.H. , Hung M.C.
Biochem. Biophys. Res. Commun.399:498-504(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH COPG1;SUBCELLULAR LOCATION;TOPOLOGY
65.

"Nuclear alternate estrogen receptor GPR30 mediates 17beta-estradiol-induced gene expression and migration in breast cancer-associated fibroblasts."
Madeo A. , Maggiolini M.
Cancer Res.70:6036-6046(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GPER1;SUBCELLULAR LOCATION
66.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-693; SER-991; SER-1064 AND TYR-1197;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
67.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
68.

"Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells."
Huang W.C. , Chen Y.J. , Li L.Y. , Wei Y.L. , Hsu S.C. , Tsai S.L. , Chiu P.C. , Huang W.P. , Wang Y.N. , Chen C.H. , Chang W.C. , Chang W.C. , Chen A.J. , Tsai C.H. , Hung M.C.
J. Biol. Chem.286:20558-20568(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-229
69.

"Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation."
Hsu J.M. , Chen C.T. , Chou C.K. , Kuo H.P. , Li L.Y. , Lin C.Y. , Lee H.J. , Wang Y.N. , Liu M. , Liao H.W. , Shi B. , Lai C.C. , Bedford M.T. , Tsai C.H. , Hung M.C.
Nat. Cell Biol.13:174-181(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL PROLIFERATION AND CELL MIGRATION;METHYLATION AT ARG-1199 BY PRMT5;INTERACTION WITH PRMT5 AND PTPN6
70.

"FER tyrosine kinase (FER) overexpression mediates resistance to quinacrine through EGF-dependent activation of NF-kappaB."
Guo C. , Stark G.R.
Proc. Natl. Acad. Sci. U.S.A.108:7968-7973(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FER;PHOSPHORYLATION
71.

"The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane."
Tanno H. , Yamaguchi T. , Goto E. , Ishido S. , Komada M.
Mol. Biol. Cell23:1343-1353(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ANKRD13A; ANKRD13B AND ALKRD13D;UBIQUITINATION;SUBCELLULAR LOCATION
72.

"Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression."
Pareja F. , Ferraro D.A. , Rubin C. , Cohen-Dvashi H. , Zhang F. , Aulmann S. , Ben-Chetrit N. , Pines G. , Navon R. , Crosetto N. , Kostler W. , Carvalho S. , Lavi S. , Schmitt F. , Dikic I. , Yakhini Z. , Sinn P. , Mills G.B. , more...
Oncogene31:4599-4608(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;DEUBIQUITINATION BY OTUD7B
73.

"The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor."
Smith C.J. , Berry D.M. , McGlade C.J.
J. Cell Sci.126:1366-1380(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF115 AND RNF126
74.

"Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains."
Ogiso H. , Ishitani R. , Nureki O. , Fukai S. , Yamanaka M. , Kim J.H. , Saito K. , Sakamoto A. , Inoue M. , Shirouzu M. , Yokoyama S.
Cell110:775-787(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 25-646 IN COMPLEX WITH EGF;FUNCTION IN MAPK1 AND/OR MAPK3 ACTIVATION;SUBUNIT;SUBCELLULAR LOCATION;MUTAGENESIS OF TYR-275; PHE-287; ARG-309 AND ARG-429;DISULFIDE BONDS;GLYCOSYLATION AT ASN-56; ASN-175; ASN-196; ASN-352; ASN-361 AND ASN-444
75.

"EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization."
Ferguson K.M. , Berger M.B. , Mendrola J.M. , Cho H.S. , Leahy D.J. , Lemmon M.A.
Mol. Cell11:507-517(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 25-642 IN COMPLEX WITH EGF;FUNCTION;SUBUNIT;MUTAGENESIS OF 587-ASP--HIS-590 AND LYS-609;DISULFIDE BONDS;GLYCOSYLATION AT ASN-352; ASN-361; ASN-444; ASN-528; ASN-568 AND ASN-603
76.

"A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells."
Wood E.R. , Truesdale A.T. , McDonald O.B. , Yuan D. , Hassell A. , Dickerson S.H. , Ellis B. , Pennisi C. , Horne E. , Lackey K. , Alligood K.J. , Rusnak D.W. , Gilmer T.M. , Shewchuk L.
Cancer Res.64:6652-6659(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 695-1022 IN COMPLEX WITH GW572016;CATALYTIC ACTIVITY;FUNCTION
77.

"Structural basis for inhibition of the epidermal growth factor receptor by cetuximab."
Li S. , Schmitz K.R. , Jeffrey P.D. , Wiltzius J.J. , Kussie P. , Ferguson K.M.
Cancer Cell7:301-311(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 25-642 IN COMPLEX WITH CETUXIMAB
78.

"A structural model for the membrane-bound form of the juxtamembrane domain of the epidermal growth factor receptor."
Choowongkomon K. , Carlin C.R. , Sonnichsen F.D.
J. Biol. Chem.280:24043-24052(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 669-721
79.

"Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity."
Yun C.H. , Boggon T.J. , Li Y. , Woo M.S. , Greulich H. , Meyerson M. , Eck M.J.
Cancer Cell11:217-227(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.47 ANGSTROMS) OF 696-1022 OF WILD-TYPE AND VARIANTS SER-719 AND ARG-858 IN COMPLEXES WITH ATP ANALOGS AND SYNTHETIC INHIBITORS;CATALYTIC ACTIVITY;AUTOPHOSPHORYLATION;CHARACTERIZATION OF VARIANTS SER-719 AND ARG-858
80.

"Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface."
Zhang X. , Pickin K.A. , Bose R. , Jura N. , Cole P.A. , Kuriyan J.
Nature450:741-744(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 702-1022 IN COMPLEX WITH ERRFI1;ENZYME REGULATION;CATALYTIC ACTIVITY;AUTOPHOSPHORYLATION;SUBUNIT;INTERACTION WITH ERRFI1
81.

"The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP."
Yun C.H. , Mengwasser K.E. , Toms A.V. , Woo M.S. , Greulich H. , Wong K.K. , Meyerson M. , Eck M.J.
Proc. Natl. Acad. Sci. U.S.A.105:2070-2075(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.05 ANGSTROMS) OF 695-1022 OF VARIANT MET-790;CATALYTIC ACTIVITY;CHARACTERIZATION OF VARIANT MET-790
82.

"Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment."
Jura N. , Endres N.F. , Engel K. , Deindl S. , Das R. , Lamers M.H. , Wemmer D.E. , Zhang X. , Kuriyan J.
Cell137:1293-1307(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.96 ANGSTROMS) OF 696-1022;CATALYTIC ACTIVITY;PHOSPHORYLATION AT TYR-998; TYR-1016 AND TYR-1197;MUTAGENESIS OF LEU-688; GLU-690; LEU-692; ARG-977 AND 1005-GLU-ASP-1006;SUBUNIT
83.

"The juxtamembrane region of the EGF receptor functions as an activation domain."
Red Brewer M. , Choi S.H. , Alvarado D. , Moravcevic K. , Pozzi A. , Lemmon M.A. , Carpenter G.
Mol. Cell34:641-651(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 669-1022 OF MUTANT MET-745;CATALYTIC ACTIVITY;FUNCTION;SUBUNIT;SUBCELLULAR LOCATION;AUTOPHOSPHORYLATION;MUTAGENESIS OF LEU-688; VAL-689; GLU-690; LEU-692; THR-693; PRO-694; PRO-699; ASN-700; LEU-704; ARG-705; ILE-706 AND LYS-745
84.

"Spatial structure of the transmembrane domain heterodimer of ErbB1 and ErbB2 receptor tyrosine kinases."
Mineev K.S. , Bocharov E.V. , Pustovalova Y.E. , Bocharova O.V. , Chupin V.V. , Arseniev A.S.
J. Mol. Biol.400:231-243(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 634-677 IN COMPLEX WITH ERBB2;SUBUNIT
85.

"Structural evidence for loose linkage between ligand binding and kinase activation in the epidermal growth factor receptor."
Lu C. , Mi L.Z. , Grey M.J. , Zhu J. , Graef E. , Yokoyama S. , Springer T.A.
Mol. Cell. Biol.30:5432-5443(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 25-638 IN COMPLEX WITH EGF;FUNCTION;SUBUNIT;DISULFIDE BONDS;GLYCOSYLATION AT ASN-56; ASN-73; ASN-175; ASN-196; ASN-352; ASN-361; ASN-444 AND ASN-528
86.

"Crystal structure of Cbl-b TKB domain in complex with EGFR pY1069 peptide."
Structural genomics consortium
Submitted (2010-10) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.27 ANGSTROMS) OF 1066-1076 IN COMPLEX WITH CBLB;INTERACTION WITH CBLB
87.

"Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c."
Takeshita K. , Tezuka T. , Isozaki Y. , Yamashita E. , Suzuki M. , Kim M. , Yamanashi Y. , Yamamoto T. , Nakagawa A.
J. Biochem.152:487-495(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.52 ANGSTROMS) OF 1062-1074 IN COMPLEX WITH CBLC;PHOSPHORYLATION AT TYR-1069;INTERACTION WITH CBLC;MUTAGENESIS OF GLN-1067; ARG-1068 AND TYR-1069
88.

"High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan."
Huang S.F. , Liu H.P. , Li L.H. , Ku Y.C. , Fu Y.N. , Tsai H.Y. , Chen Y.T. , Lin Y.F. , Chang W.C. , Kuo H.P. , Wu Y.C. , Chen Y.R. , Tsai S.F.
Clin. Cancer Res.10:8195-8203(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALA-709; GLY-709; CYS-719; SER-719; 746-GLU--ALA-750 DEL; 746-GLU--THR-751 DELINS ALA; 746-GLU--SER-752 DELINS ASP; 747-LEU--THR-751 DEL; ILE-768; MET-769; VAL-833; LEU-835; VAL-838; ARG-858 AND GLN-861
89.

"EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy."
Paez J.G. , Janne P.A. , Lee J.C. , Tracy S. , Greulich H. , Gabriel S. , Herman P. , Kaye F.J. , Lindeman N. , Boggon T.J. , Naoki K. , Sasaki H. , Fujii Y. , Eck M.J. , Sellers W.R. , Johnson B.E. , Meyerson M.
Science304:1497-1500(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SER-719 AND ARG-858;POSSIBLE INVOLVEMENT IN LUNG CANCER
90.

"Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features."
Tam I.Y.S. , Chung L.P. , Suen W.S. , Wang E. , Wong M.C.M. , Ho K.K. , Lam W.K. , Chiu S.W. , Girard L. , Minna J.D. , Gazdar A.F. , Wong M.P.
Clin. Cancer Res.12:1647-1653(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALA-709; LYS-709; ALA-719; ASP-719; CYS-719; SER-719; SER-724; LYS-734; GLU-746 DEL; PHE-747; 747-LEU--GLU-749 DEL; PRO-748; 752-SER--ILE-759 DEL; ARG-787; MET-790; VAL-833; LEU-834; MET-858; ARG-858; GLN-861 AND GLU-873;POSSIBLE INVOLVEMENT IN LUNG CANCER
91.

"Distinctive activation patterns in constitutively active and gefitinib-sensitive EGFR mutants."
Chen Y.R. , Fu Y.N. , Lin C.H. , Yang S.T. , Hu S.F. , Chen Y.T. , Tsai S.F. , Huang S.F.
Oncogene25:1205-1215(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS ALA-709; GLY-709; SER-719; ILE-768; VAL-833; LEU-835; VAL-838; ARG-858 AND GLN-861
92.

"Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors."
Ji H. , Zhao X. , Yuza Y. , Shimamura T. , Li D. , Protopopov A. , Jung B.L. , McNamara K. , Xia H. , Glatt K.A. , Thomas R.K. , Sasaki H. , Horner J.W. , Eck M. , Mitchell A. , Sun Y. , Al-Hashem R. , Bronson R.T. , more...
Proc. Natl. Acad. Sci. U.S.A.103:7817-7822(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT 30-VAL--ARG-297 DEL;POSSIBLE INVOLVEMENT IN LUNG CANCER
93.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] LYS-521; ARG-1034 AND VAL-1210

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