Protein name:
Pro-epidermal growth factor (EGF) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF2 (By similarity). Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD).
Function:
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MLLTLIILLP | VVSKFSFVSL | SAPQHWSCPE | GTLAGNGNST | CVGPAPFLIF |
100:
SHGNSIFRID | TEGTNYEQLV | VDAGVSVIMD | FHYNEKRIYW | VDLERQLLQR |
150:
VFLNGSRQER | VCNIEKNVSG | MAINWINEEV | IWSNQQEGII | TVTDMKGNNS |
200:
HILLSALKYP | ANVAVDPVER | FIFWSSEVAG | SLYRADLDGV | GVKALLETSE |
250:
KITAVSLDVL | DKRLFWIQYN | REGSNSLICS | CDYDGGSVHI | SKHPTQHNLF |
300:
AMSLFGDRIF | YSTWKMKTIW | IANKHTGKDM | VRINLHSSFV | PLGELKVVHP |
350:
LAQPKAEDDT | WEPEQKLCKL | RKGNCSSTVC | GQDLQSHLCM | CAEGYALSRD |
400:
RKYCEDVNEC | AFWNHGCTLG | CKNTPGSYYC | TCPVGFVLLP | DGKRCHQLVS |
450:
CPRNVSECSH | DCVLTSEGPL | CFCPEGSVLE | RDGKTCSGCS | SPDNGGCSQL |
500:
CVPLSPVSWE | CDCFPGYDLQ | LDEKSCAASG | PQPFLLFANS | QDIRHMHFDG |
550:
TDYGTLLSQQ | MGMVYALDHD | PVENKIYFAH | TALKWIERAN | MDGSQRERLI |
600:
EEGVDVPEGL | AVDWIGRRFY | WTDRGKSLIG | RSDLNGKRSK | IITKENISQP |
650:
RGIAVHPMAK | RLFWTDTGIN | PRIESSSLQG | LGRLVIASSD | LIWPSGITID |
700:
FLTDKLYWCD | AKQSVIEMAN | LDGSKRRRLT | QNDVGHPFAV | AVFEDYVWFS |
750:
DWAMPSVMRV | NKRTGKDRVR | LQGSMLKPSS | LVVVHPLAKP | GADPCLYQNG |
800:
GCEHICKKRL | GTAWCSCREG | FMKASDGKTC | LALDGHQLLA | GGEVDLKNQV |
850:
TPLDILSKTR | VSEDNITESQ | HMLVAEIMVS | DQDDCAPVGC | SMYARCISEG |
900:
EDATCQCLKG | FAGDGKLCSD | IDECEMGVPV | CPPASSKCIN | TEGGYVCRCS |
950:
EGYQGDGIHC | LDIDECQLGE | HSCGENASCT | NTEGGYTCMC | AGRLSEPGLI |
1000:
CPDSTPPPHL | REDDHHYSVR | NSDSECPLSH | DGYCLHDGVC | MYIEALDKYA |
1050:
CNCVVGYIGE | RCQYRDLKWW | ELRHAGHGQQ | QKVIVVAVCV | VVLVMLLLLS |
1100:
LWGAHYYRTQ | KLLSKNPKNP | YEESSRDVRS | RRPADTEDGM | SSCPQPWFVV |
1150:
IKEHQDLKNG | GQPVAGEDGQ | AADGSMQPTS | WRQEPQLCGM | GTEQGCWIPV |
1200:
SSDKGSCPQV | MERSFHMPSY | GTQTLEGGVE | KPHSLLSANP | LWQQRALDPP |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Dog
Mouse
Rat
Pig
Polyclonal Antibody for Human EGF
Polyclonal Antibody for Human EGF
Polyclonal Antibody for Human EGF
Polyclonal Antibody for Human EGF
Polyclonal Antibody for Human EGF
Monoclonal Antibody for Human EGF
Monoclonal Antibody for Human EGF
Monoclonal Antibody for Human EGF
Monoclonal Antibody for Human EGF
Monoclonal Antibody for Human EGF
R&D Technical Data
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Precision
Intra-Assay CV: ≤4.3
Inter-Assay CV: ≤7.5
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Recovery
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Linearity
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Citations
[1].
Meixia Zhang, Xiaolei Shan, Li Guv, Leif Hertz and Liang Peng
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT VAL-920
tissue :
Teratocarcinoma .
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Colon .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[
Abstract ]
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Cited for : X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 971-1023 IN COMPLEX WITH EGFR;DISULFIDE BONDS
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Cited for : X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 971-1023 IN COMPLEX WITH EGFR;DISULFIDE BONDS
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Cited for : STRUCTURE BY NMR OF 971-1023 IN COMPLEX WITH SURAMIN
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Cited for : X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 975-1021 IN COMPLEX WITH EGFR;DISULFIDE BONDS