Protein name:
Pro-epidermal growth factor (EGF) ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD). Interacts with RHBDF2.
Function:
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MPWGRRPTWL | LLAFLLVFLK | ISILSVTAWQ | TGNCQPGPLE | RSERSGTCAG |
100:
PAPFLVFSQG | KSISRIDPDG | TNHQQLVVDA | GISADMDIHY | KKERLYWVDV |
150:
ERQVLLRVFL | NGTGLEKVCN | VERKVSGLAI | DWIDDEVLWV | DQQNGVITVT |
200:
DMTGKNSRVL | LSSLKHPSNI | AVDPIERLMF | WSSEVTGSLH | RAHLKGVDVK |
250:
TLLETGGISV | LTLDVLDKRL | FWVQDSGEGS | HAYIHSCDYE | GGSVRLIRHQ |
300:
ARHSLSSMAF | FGDRIFYSVL | KSKAIWIANK | HTGKDTVRIN | LHPSFVTPGK |
350:
LMVVHPRAQP | RTEDAAKDPD | PELLKQRGRP | CRFGLCERDP | KSHSSACAEG |
400:
YTLSRDRKYC | EDVNECATQN | HGCTLGCENT | PGSYHCTCPT | GFVLLPDGKQ |
450:
CHELVSCPGN | VSKCSHGCVL | TSDGPRCICP | AGSVLGRDGK | TCTGCSSPDN |
500:
GGCSQICLPL | RPGSWECDCF | PGYDLQSDRK | SCAASGPQPL | LLFANSQDIR |
550:
HMHFDGTDYK | VLLSRQMGMV | FALDYDPVES | KIYFAQTALK | WIERANMDGS |
600:
QRERLITEGV | DTLEGLALDW | IGRRIYWTDS | GKSVVGGSDL | SGKHHRIIIQ |
650:
ERISRPRGIA | VHPRARRLFW | TDVGMSPRIE | SASLQGSDRV | LIASSNLLEP |
700:
SGITIDYLTD | TLYWCDTKRS | VIEMANLDGS | KRRRLIQNDV | GHPFSLAVFE |
750:
DHLWVSDWAI | PSVIRVNKRT | GQNRVRLQGS | MLKPSSLVVV | HPLAKPGADP |
800:
CLYRNGGCEH | ICQESLGTAR | CLCREGFVKA | WDGKMCLPQD | YPILSGENAD |
850:
LSKEVTSLSN | STQAEVPDDD | GTESSTLVAE | IMVSGMNYED | DCGPGGCGSH |
900:
ARCVSDGETA | ECQCLKGFAR | DGNLCSDIDE | CVLARSDCPS | TSSRCINTEG |
950:
GYVCRCSEGY | EGDGISCFDI | DECQRGAHNC | GENAACTNTE | GGYNCTCAGR |
1000:
PSSPGLSCPD | STAPSLLGED | GHHLDRNSYP | GCPSSYDGYC | LNGGVCMHIE |
1050:
SLDSYTCNCV | IGYSGDRCQT | RDLRWWELRH | AGYGQKHDIM | VVAVCMVALV |
1100:
LLLVLGMWGT | YYYRTRKQLS | NPPKNPCDEP | SGSVSSSGPN | SSSGAAVASC |
1150:
PQPWFVVLEK | HQDPKNGSLP | ADGTNGAVVD | AGLSPSLQLG | SVHLTSWRQK |
1200:
PHIDGMGTGQ | SCWIPPSSDR | GPQEIEGNSH | LPSYRPVGPE | KLHSLQSANG |
1217:
SCHERAPDLP | RQTEPVQ
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Dog
Mouse
Rat
Pig
Polyclonal Antibody for Mouse EGF
Polyclonal Antibody for Mouse EGF
Polyclonal Antibody for Mouse EGF
Polyclonal Antibody for Mouse EGF
Polyclonal Antibody for Mouse EGF
Monoclonal Antibody for Mouse EGF
Monoclonal Antibody for Mouse EGF
Monoclonal Antibody for Mouse EGF
Monoclonal Antibody for Mouse EGF
Monoclonal Antibody for Mouse EGF
R&D Technical Data
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Precision
Intra-Assay CV: ≤4.3
Inter-Assay CV: ≤7.5
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M.
,
Goodstadt L.
,
Hillier L.W.
,
Zody M.C.
,
Goldstein S.
,
She X.
,
Bult C.J.
,
Agarwala R.
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Cherry J.L.
,
DiCuccio M.
,
Hlavina W.
,
Kapustin Y.
,
Meric P.
,
Maglott D.
,
Birtle Z.
,
Marques A.C.
,
Graves T.
,
Zhou S.
,
Teague B.
,
Potamousis K.
,
Churas C.
,
Place M.
,
Herschleb J.
,
Runnheim R.
,
Forrest D.
,
Amos-Landgraf J.
,
Schwartz D.C.
,
Cheng Z.
,
Lindblad-Toh K.
,
Eichler E.E.
,
Ponting C.P.
more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
FVB/N .
tissue :
Kidney .
tissue :
Salivary gland .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 977-1029
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISULFIDE BONDS
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RHBDF1 AND RHBDF2
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 977-1029
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 977-1029
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 980-1024