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Index > Protein center > Egf(Gene name) > Mouse
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  • Egf (Gene name),
  • Pro-epidermal growth factor (Protein name ),  EGF_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Egf;
    Protein name:
    Pro-epidermal growth factor(EGF);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD). Interacts with RHBDF2.
    Function:
    EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1217
    Sequence:
    50:
    MPWGRRPTWL | LLAFLLVFLK | ISILSVTAWQ | TGNCQPGPLE | RSERSGTCAG | 
    100:
    PAPFLVFSQG | KSISRIDPDG | TNHQQLVVDA | GISADMDIHY | KKERLYWVDV | 
    150:
    ERQVLLRVFL | NGTGLEKVCN | VERKVSGLAI | DWIDDEVLWV | DQQNGVITVT | 
    200:
    DMTGKNSRVL | LSSLKHPSNI | AVDPIERLMF | WSSEVTGSLH | RAHLKGVDVK | 
    250:
    TLLETGGISV | LTLDVLDKRL | FWVQDSGEGS | HAYIHSCDYE | GGSVRLIRHQ | 
    300:
    ARHSLSSMAF | FGDRIFYSVL | KSKAIWIANK | HTGKDTVRIN | LHPSFVTPGK | 
    350:
    LMVVHPRAQP | RTEDAAKDPD | PELLKQRGRP | CRFGLCERDP | KSHSSACAEG | 
    400:
    YTLSRDRKYC | EDVNECATQN | HGCTLGCENT | PGSYHCTCPT | GFVLLPDGKQ | 
    450:
    CHELVSCPGN | VSKCSHGCVL | TSDGPRCICP | AGSVLGRDGK | TCTGCSSPDN | 
    500:
    GGCSQICLPL | RPGSWECDCF | PGYDLQSDRK | SCAASGPQPL | LLFANSQDIR | 
    550:
    HMHFDGTDYK | VLLSRQMGMV | FALDYDPVES | KIYFAQTALK | WIERANMDGS | 
    600:
    QRERLITEGV | DTLEGLALDW | IGRRIYWTDS | GKSVVGGSDL | SGKHHRIIIQ | 
    650:
    ERISRPRGIA | VHPRARRLFW | TDVGMSPRIE | SASLQGSDRV | LIASSNLLEP | 
    700:
    SGITIDYLTD | TLYWCDTKRS | VIEMANLDGS | KRRRLIQNDV | GHPFSLAVFE | 
    750:
    DHLWVSDWAI | PSVIRVNKRT | GQNRVRLQGS | MLKPSSLVVV | HPLAKPGADP | 
    800:
    CLYRNGGCEH | ICQESLGTAR | CLCREGFVKA | WDGKMCLPQD | YPILSGENAD | 
    850:
    LSKEVTSLSN | STQAEVPDDD | GTESSTLVAE | IMVSGMNYED | DCGPGGCGSH | 
    900:
    ARCVSDGETA | ECQCLKGFAR | DGNLCSDIDE | CVLARSDCPS | TSSRCINTEG | 
    950:
    GYVCRCSEGY | EGDGISCFDI | DECQRGAHNC | GENAACTNTE | GGYNCTCAGR | 
    1000:
    PSSPGLSCPD | STAPSLLGED | GHHLDRNSYP | GCPSSYDGYC | LNGGVCMHIE | 
    1050:
    SLDSYTCNCV | IGYSGDRCQT | RDLRWWELRH | AGYGQKHDIM | VVAVCMVALV | 
    1100:
    LLLVLGMWGT | YYYRTRKQLS | NPPKNPCDEP | SGSVSSSGPN | SSSGAAVASC | 
    1150:
    PQPWFVVLEK | HQDPKNGSLP | ADGTNGAVVD | AGLSPSLQLG | SVHLTSWRQK | 
    1200:
    PHIDGMGTGQ | SCWIPPSSDR | GPQEIEGNSH | LPSYRPVGPE | KLHSLQSANG | 
    1217:
    SCHERAPDLP | RQTEPVQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    KEGG:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse EGF
    Cat.:
    E0560h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse EGF
    Cat.:
    E0560d
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
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    ELISA Kit for Mouse EGF
    Cat.:
    E0560m
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    MSDS:
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    96T
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    ELISA Kit for Mouse EGF
    Cat.:
    E0560r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse EGF
    Cat.:
    E0560p
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse EGF
    Cat.:
    U0560p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse EGF
    Cat.:
    U0560r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse EGF
    Cat.:
    U0560m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse EGF
    Cat.:
    U0560d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse EGF
    Cat.:
    U0560h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Mouse EGF
    Polyclonal Antibody for Mouse EGF
    Cat.:
    P0560Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse EGF
    Polyclonal Antibody for Mouse EGF
    Cat.:
    P0560Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse EGF
    Cat.:
    P0560Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse EGF
    Monoclonal Antibody for Mouse EGF
    Monoclonal Antibody for Mouse EGF
    Monoclonal Antibody for Mouse EGF
    Monoclonal Antibody for Mouse EGF
    Protein for Mouse EGF
    Protein for Mouse EGF
    Protein for Mouse EGF
    Protein for Mouse EGF
    Protein for Mouse EGF

    R&D Technical Data
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    Precision

    Intra-Assay CV: ≤4.3

    Inter-Assay CV: ≤7.5

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    Recovery
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    Linearity
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    References
    1. 1.
      "Structure of a mouse submaxillary messenger RNA encoding epidermal growth factor and seven related proteins."
      Scott J. , Urdea M. , Quiroga M. , Sanchez-Pescador R. , Fong N.M. , Selby M. , Rutter W.J. , Bell G.I.
      Science221:236-240(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor."
      Gray A. , Dull T.J. , Ullrich A.
      Nature303:722-725(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Kidney.
      tissue: Salivary gland.
    5. 5.
      "The primary structure of epidermal growth factor."
      Savage C.R. Jr. , Inagami T. , Cohen S.
      J. Biol. Chem.247:7612-7621(1972) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 977-1029
    6. 6.
      "Epidermal growth factor. Location of disulfide bonds."
      Savage C.R. Jr. , Hash J.H. , Cohen S.
      J. Biol. Chem.248:7669-7672(1973) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
    7. 7.
      "Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling."
      Zettl M. , Adrain C. , Strisovsky K. , Lastun V. , Freeman M.
      Cell145:79-91(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RHBDF1 AND RHBDF2
    8. 8.
      "Solution structure of murine epidermal growth factor determined by NMR spectroscopy and refined by energy minimization with restraints."
      Montelione G.T. , Wuethrich K. , Burgess A.W. , Nice E.C. , Wagner G. , Gibson K.D. , Scheraga H.A.
      Biochemistry31:236-249(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 977-1029
    9. 9.
      "Three-dimensional nuclear magnetic resonance structures of mouse epidermal growth factor in acidic and physiological pH solutions."
      Kohda D. , Inagaki F.
      Biochemistry31:11928-11939(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 977-1029
    10. 10.
      "Role of the 6-20 disulfide bridge in the structure and activity of epidermal growth factor."
      Barnham K.J. , Torres A.M. , Alewood D. , Alewood P.F. , Domagala T. , Nice E.C. , Norton R.S.
      Protein Sci.7:1738-1749(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 980-1024
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