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Index > Protein center > EPHA4(Gene name) > Human
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  • EPHA4 (Gene name),
  • Ephrin type-A receptor 4 (Protein name ),  EPHA4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    EPHA4(HEK8;SEK;TYRO1);
    Protein name:
    Ephrin type-A receptor 4;
    Alternative:
    Tyrosine-protein kinase TYRO1;EPH-like kinase 8(EK8;hEK8);Tyrosine-protein kinase receptor SEK;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Interacts (phosphorylated at position Tyr-602) with FYN. Interacts with CDK5, CDK5R1 and NGEF; upon activation by EFNA1 induces NGEF phosphorylation by the kinase CDK5. Interacts with CHN1; effector of EPHA4 in axon guidance linking EPHA4 activation to RAC1 regulation (By similarity). Interacts (via PDZ motif) with SIPA1L1 (via PDZ domain); controls neuronal morphology through regulation of the RAP1 (RAP1A or RAP1B) and RAP2 (RAP2A, RAP2B or RAP2C) GTPases.
    Function:
    Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. Beside its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein Cell projection axon Cell projection dendrite Cell junction synapse postsynaptic cell membrane postsynaptic density Early endosome Clustered upon activation and targeted to early endosome.
    Protein Attributes:
    Sequence length:
    986
    Sequence:
    50:
    MAGIFYFALF | SCLFGICDAV | TGSRVYPANE | VTLLDSRSVQ | GELGWIASPL | 
    100:
    EGGWEEVSIM | DEKNTPIRTY | QVCNVMEPSQ | NNWLRTDWIT | REGAQRVYIE | 
    150:
    IKFTLRDCNS | LPGVMGTCKE | TFNLYYYESD | NDKERFIREN | QFVKIDTIAA | 
    200:
    DESFTQVDIG | DRIMKLNTEI | RDVGPLSKKG | FYLAFQDVGA | CIALVSVRVF | 
    250:
    YKKCPLTVRN | LAQFPDTITG | ADTSSLVEVR | GSCVNNSEEK | DVPKMYCGAD | 
    300:
    GEWLVPIGNC | LCNAGHEERS | GECQACKIGY | YKALSTDATC | AKCPPHSYSV | 
    350:
    WEGATSCTCD | RGFFRADNDA | ASMPCTRPPS | APLNLISNVN | ETSVNLEWSS | 
    400:
    PQNTGGRQDI | SYNVVCKKCG | AGDPSKCRPC | GSGVHYTPQQ | NGLKTTKVSI | 
    450:
    TDLLAHTNYT | FEIWAVNGVS | KYNPNPDQSV | SVTVTTNQAA | PSSIALVQAK | 
    500:
    EVTRYSVALA | WLEPDRPNGV | ILEYEVKYYE | KDQNERSYRI | VRTAARNTDI | 
    550:
    KGLNPLTSYV | FHVRARTAAG | YGDFSEPLEV | TTNTVPSRII | GDGANSTVLL | 
    600:
    VSVSGSVVLV | VILIAAFVIS | RRRSKYSKAK | QEADEEKHLN | QGVRTYVDPF | 
    650:
    TYEDPNQAVR | EFAKEIDASC | IKIEKVIGVG | EFGEVCSGRL | KVPGKREICV | 
    700:
    AIKTLKAGYT | DKQRRDFLSE | ASIMGQFDHP | NIIHLEGVVT | KCKPVMIITE | 
    750:
    YMENGSLDAF | LRKNDGRFTV | IQLVGMLRGI | GSGMKYLSDM | SYVHRDLAAR | 
    800:
    NILVNSNLVC | KVSDFGMSRV | LEDDPEAAYT | TRGGKIPIRW | TAPEAIAYRK | 
    850:
    FTSASDVWSY | GIVMWEVMSY | GERPYWDMSN | QDVIKAIEEG | YRLPPPMDCP | 
    900:
    IALHQLMLDC | WQKERSDRPK | FGQIVNMLDK | LIRNPNSLKR | TGTESSRPNT | 
    950:
    ALLDPSSPEF | SAVVSVGDWL | QAIKMDRYKD | NFTAAGYTTL | EAVVHVNQED | 
    986:
    LARIGITAIT | HQNKILSSVQ | AMRTQMQQMH | GRMVPV
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    SMR:
    Pfam:
    KEGG:
    UniGene:
    Pfam:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Ephrin type-A receptor 4
    Cat.:
    E0303m
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    ELISA Kit for Human Ephrin type-A receptor 4
    Cat.:
    E0303h
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    Packing:
    96T
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    ELISA Kit for Human Ephrin type-A receptor 4
    Cat.:
    E0303c
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Ephrin type-A receptor 4
    Cat.:
    U0303c
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Ephrin type-A receptor 4
    Cat.:
    U0303m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Ephrin type-A receptor 4
    Cat.:
    U0303h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Ephrin type-A receptor 4
    Cat.:
    P0303Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Ephrin type-A receptor 4
    Polyclonal Antibody for Human Ephrin type-A receptor 4
    Cat.:
    P0303Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Ephrin type-A receptor 4
    Monoclonal Antibody for Human Ephrin type-A receptor 4
    Monoclonal Antibody for Human Ephrin type-A receptor 4
    Protein for Human Ephrin type-A receptor 4
    Protein for Human Ephrin type-A receptor 4
    Protein for Human Ephrin type-A receptor 4

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    Linearity
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    References
    1. 1.
      "cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases."
      Fox G.M. , Holst P.L. , Chute H.T. , Lindberg R.A. , Janssen A.M. , Basu R. , Welcher A.A.
      Oncogene10:897-905(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Fetal brain.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Amygdala.
      tissue: Tongue.
    3. 3.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    5. 5.
      "Unified nomenclature for Eph family receptors and their ligands, the ephrins."
      Eph nomenclature committee
      Cell90:403-404(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NOMENCLATURE
    6. 6.
      "The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases."
      Richter M. , Murai K.K. , Bourgin C. , Pak D.T. , Pasquale E.B.
      J. Neurosci.27:14205-14215(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SIPA1L1
    7. 7.
      "Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism."
      Fu W.Y. , Chen Y. , Sahin M. , Zhao X.S. , Shi L. , Bikoff J.B. , Lai K.O. , Yung W.H. , Fu A.K. , Greenberg M.E. , Ip N.Y.
      Nat. Neurosci.10:67-76(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF CDK5;AUTOPHOSPHORYLATION
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    9. 9.
      "Crystal structure and NMR binding reveal that two small molecule antagonists target the high affinity ephrin-binding channel of the EphA4 receptor."
      Qin H. , Shi J. , Noberini R. , Pasquale E.B. , Song J.
      J. Biol. Chem.283:29473-29484(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 29-209
    10. 10.
      "Structural plasticity of EPH receptor A4 facilitates cross-class ephrin signaling."
      Bowden T.A. , Aricescu A.R. , Nettleship J.E. , Siebold C. , Rahman-Huq N. , Owens R.J. , Stuart D.I. , Jones E.Y.
      Structure17:1386-1397(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 30-202 IN COMPLEX WITH EFNA2 OR EFNB2;LIGAND-BINDING
    11. 11.
      "Structural characterization of the EphA4-Ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity."
      Qin H. , Noberini R. , Huan X. , Shi J. , Pasquale E.B. , Song J.
      J. Biol. Chem.285:644-654(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 29-203 IN COMPLEX WITH EFNB2;MUTAGENESIS OF GLN-40 AND GLU-42
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