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Index > Protein center > SLC8A1(Gene name) > Human
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  • SLC8A1 (Gene name),
  • Sodium/calcium exchanger 1 (Protein name ),  NAC1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    SLC8A1(CNC;NCX1);
    Protein name:
    Sodium/calcium exchanger 1;
    Alternative:
    Solute carrier family 8 member 1;Na(+)/Ca(2+)-exchange protein 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    973
    Sequence:
    50:
    MYNMRRLSLS | PTFSMGFHLL | VTVSLLFSHV | DHVIAETEME | GEGNETGECT | 
    100:
    GSYYCKKGVI | LPIWEPQDPS | FGDKIARATV | YFVAMVYMFL | GVSIIADRFM | 
    150:
    SSIEVITSQE | KEITIKKPNG | ETTKTTVRIW | NETVSNLTLM | ALGSSAPEIL | 
    200:
    LSVIEVCGHN | FTAGDLGPST | IVGSAAFNMF | IIIALCVYVV | PDGETRKIKH | 
    250:
    LRVFFVTAAW | SIFAYTWLYI | ILSVISPGVV | EVWEGLLTFF | FFPICVVFAW | 
    300:
    VADRRLLFYK | YVYKRYRAGK | QRGMIIEHEG | DRPSSKTEIE | MDGKVVNSHV | 
    350:
    ENFLDGALVL | EVDERDQDDE | EARREMARIL | KELKQKHPDK | EIEQLIELAN | 
    400:
    YQVLSQQQKS | RAFYRIQATR | LMTGAGNILK | RHAADQARKA | VSMHEVNTEV | 
    450:
    TENDPVSKIF | FEQGTYQCLE | NCGTVALTII | RRGGDLTNTV | FVDFRTEDGT | 
    500:
    ANAGSDYEFT | EGTVVFKPGD | TQKEIRVGII | DDDIFEEDEN | FLVHLSNVKV | 
    550:
    SSEASEDGIL | EANHVSTLAC | LGSPSTATVT | IFDDDHAGIF | TFEEPVTHVS | 
    600:
    ESIGIMEVKV | LRTSGARGNV | IVPYKTIEGT | ARGGGEDFED | TCGELEFQND | 
    650:
    EIVKTISVKV | IDDEEYEKNK | TFFLEIGEPR | LVEMSEKKAL | LLNELGGFTI | 
    700:
    TGKYLFGQPV | FRKVHAREHP | ILSTVITIAD | EYDDKQPLTS | KEEEERRIAE | 
    750:
    MGRPILGEHT | KLEVIIEESY | EFKSTVDKLI | KKTNLALVVG | TNSWREQFIE | 
    800:
    AITVSAGEDD | DDDECGEEKL | PSCFDYVMHF | LTVFWKVLFA | FVPPTEYWNG | 
    850:
    WACFIVSILM | IGLLTAFIGD | LASHFGCTIG | LKDSVTAVVF | VALGTSVPDT | 
    900:
    FASKVAATQD | QYADASIGNV | TGSNAVNVFL | GIGVAWSIAA | IYHAANGEQF | 
    950:
    KVSPGTLAFS | VTLFTIFAFI | NVGVLLYRRR | PEIGGELGGP | RTAKLLTSCL | 
    973:
    FVLLWLLYIF | FSSLEAYCHI | KGF
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    MIM:
    Pfam:
    UniGene:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Sodium/calcium exchanger 1
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    E0315h
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    ELISA Kit for Human Sodium/calcium exchanger 1
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    E0315m
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    ELISA Kit for Human Sodium/calcium exchanger 1
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    ELISA Kit for Human Sodium/calcium exchanger 1
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    E0315b
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    ELISA Kit for Human Sodium/calcium exchanger 1
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    E0315d
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    CLIA Kit for Human Sodium/calcium exchanger 1
    Cat.:
    U0315r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Sodium/calcium exchanger 1
    Cat.:
    U0315h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Sodium/calcium exchanger 1
    Cat.:
    U0315m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Sodium/calcium exchanger 1
    Cat.:
    U0315d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Sodium/calcium exchanger 1
    Cat.:
    U0315b
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Sodium/calcium exchanger 1
    Polyclonal Antibody for Human Sodium/calcium exchanger 1
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    P0315Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Sodium/calcium exchanger 1
    Polyclonal Antibody for Human Sodium/calcium exchanger 1
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    P0315Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Sodium/calcium exchanger 1
    Cat.:
    P0315Rb-m
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Sodium/calcium exchanger 1
    Monoclonal Antibody for Human Sodium/calcium exchanger 1
    Monoclonal Antibody for Human Sodium/calcium exchanger 1
    Monoclonal Antibody for Human Sodium/calcium exchanger 1
    Monoclonal Antibody for Human Sodium/calcium exchanger 1
    Protein for Human Sodium/calcium exchanger 1
    Protein for Human Sodium/calcium exchanger 1
    Protein for Human Sodium/calcium exchanger 1
    Protein for Human Sodium/calcium exchanger 1
    Protein for Human Sodium/calcium exchanger 1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning and characterization of the human cardiac Na+/Ca2+ exchanger cDNA."
      Komuro I. , Wenninger K.E. , Philipson K.D. , Izumo S.
      Proc. Natl. Acad. Sci. U.S.A.89:4769-4773(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Heart.
    2. 2.
      "NCX1 Na/Ca exchanger splice variants in pancreatic islet cells."
      Van Eylen F. , Bollen A. , Herchuelz A.
      J. Endocrinol.168:517-526(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 7)
    3. 3.
      "Na+/Ca2+ exchanger isoforms in cultured human retinal pigment epithelium."
      Mangini N.J. , Chen W. , Wang Q. , Kennedy B.G.
      Submitted (1999-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7)
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Placenta.
    5. 5.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "Na+/Ca2+ exchanger isoforms of rat odontoblasts and osteoblasts."
      Lundquist P. , Lundgren T. , Gritli-Linde A. , Linde A.
      Calcif. Tissue Int.67:60-67(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 459-681 (ISOFORM 10)
    8. 8.
      "Homo sapiens protein coding cDNA."
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
      Submitted (2005-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 558-973 (ISOFORM 5)
      tissue: Brain.
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 594-973 (ISOFORM 5)
    10. 10.
      "Functional expression of human renal Na+/Ca2+ exchanger in insect cells."
      Loo T.W. , Clarke D.M.
      Am. J. Physiol.267:F70-F74(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 600-684 (ISOFORM 3)
      tissue: Embryonic kidney.
    11. 11.
      "Expression of the Na-Ca exchanger in diverse tissues: a study using the cloned human cardiac Na-Ca exchanger."
      Kofuji P. , Hadley R.W. , Kieval R.S. , Lederer W.J. , Schulze D.H.
      Am. J. Physiol.263:C1241-C1249(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    12. 12.
      "The topology of the cardiac Na(+)/Ca(2)(+) exchanger, NCX1."
      Ren X. , Philipson K.D.
      J. Mol. Cell. Cardiol.57:68-71(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TOPOLOGY
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