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Index > Protein center > PDGFRA(Gene name) > Human
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  • PDGFRA (Gene name),
  • Alpha-type platelet-derived growth factor receptor (Protein name ),  PGFRA_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PDGFRA(PDGFR2;RHEPDGFRA);
    Protein name:
    Alpha-type platelet-derived growth factor receptor(PDGF-R-alpha);
    Alternative:
    CD140a antigen;CD140 antigen-like family member A;CD140a antigen;CD140 antigen-like family member A;Platelet-derived growth factor receptor 2(PDGFR-2);Platelet-derived growth factor alpha receptor;
    CD:
    CD140a;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer, and heterodimer with PDGFRB. Interacts with the SH2 domain of SHB via phosphorylated Tyr-720 (By similarity). Interacts with the SH2 domain of SHF via phosphorylated Tyr-720.
    Function:
    Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1089
    Sequence:
    50:
    MGTSHPAFLV | LGCLLTGLSL | ILCQLSLPSI | LPNENEKVVQ | LNSSFSLRCF | 
    100:
    GESEVSWQYP | MSEEESSDVE | IRNEENNSGL | FVTVLEVSSA | SAAHTGLYTC | 
    150:
    YYNHTQTEEN | ELEGRHIYIY | VPDPDVAFVP | LGMTDYLVIV | EDDDSAIIPC | 
    200:
    RTTDPETPVT | LHNSEGVVPA | SYDSRQGFNG | TFTVGPYICE | ATVKGKKFQT | 
    250:
    IPFNVYALKA | TSELDLEMEA | LKTVYKSGET | IVVTCAVFNN | EVVDLQWTYP | 
    300:
    GEVKGKGITM | LEEIKVPSIK | LVYTLTVPEA | TVKDSGDYEC | AARQATREVK | 
    350:
    EMKKVTISVH | EKGFIEIKPT | FSQLEAVNLH | EVKHFVVEVR | AYPPPRISWL | 
    400:
    KNNLTLIENL | TEITTDVEKI | QEIRYRSKLK | LIRAKEEDSG | HYTIVAQNED | 
    450:
    AVKSYTFELL | TQVPSSILDL | VDDHHGSTGG | QTVRCTAEGT | PLPDIEWMIC | 
    500:
    KDIKKCNNET | SWTILANNVS | NIITEIHSRD | RSTVEGRVTF | AKVEETIAVR | 
    550:
    CLAKNLLGAE | NRELKLVAPT | LRSELTVAAA | VLVLLVIVII | SLIVLVVIWK | 
    600:
    QKPRYEIRWR | VIESISPDGH | EYIYVDPMQL | PYDSRWEFPR | DGLVLGRVLG | 
    650:
    SGAFGKVVEG | TAYGLSRSQP | VMKVAVKMLK | PTARSSEKQA | LMSELKIMTH | 
    700:
    LGPHLNIVNL | LGACTKSGPI | YIITEYCFYG | DLVNYLHKNR | DSFLSHHPEK | 
    750:
    PKKELDIFGL | NPADESTRSY | VILSFENNGD | YMDMKQADTT | QYVPMLERKE | 
    800:
    VSKYSDIQRS | LYDRPASYKK | KSMLDSEVKN | LLSDDNSEGL | TLLDLLSFTY | 
    850:
    QVARGMEFLA | SKNCVHRDLA | ARNVLLAQGK | IVKICDFGLA | RDIMHDSNYV | 
    900:
    SKGSTFLPVK | WMAPESIFDN | LYTTLSDVWS | YGILLWEIFS | LGGTPYPGMM | 
    950:
    VDSTFYNKIK | SGYRMAKPDH | ATSEVYEIMV | KCWNSEPEKR | PSFYHLSEIV | 
    1000:
    ENLLPGQYKK | SYEKIHLDFL | KSDHPAVARM | RVDSDNAYIG | VTYKNEEDKL | 
    1050:
    KDWEGGLDEQ | RLSADSGYII | PLPDIDPVPE | EEDLGKRNRH | SSQTSEESAI | 
    1089:
    ETGSSSSTFI | KREDETIEDI | DMMDDIGIDS | SDLVEDSFL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    Pfam:
    SMR:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human PDGF-R-alpha
    Cat.:
    E0111h
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    MSDS:
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    96T
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    ELISA Kit for Human PDGF-R-alpha
    Cat.:
    E0111r
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    96T
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    ELISA Kit for Human PDGF-R-alpha
    Cat.:
    E0111c
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    Packing:
    96T
    ELISA Kit for Human PDGF-R-alpha
    Cat.:
    E0111m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PDGF-R-alpha
    Cat.:
    U0111m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human PDGF-R-alpha
    Cat.:
    U0111h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human PDGF-R-alpha
    Cat.:
    U0111c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PDGF-R-alpha
    Cat.:
    U0111r
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human PDGF-R-alpha
    Cat.:
    P0111Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PDGF-R-alpha
    Cat.:
    P0111Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PDGF-R-alpha
    Cat.:
    P0111Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PDGF-R-alpha
    Monoclonal Antibody for Human PDGF-R-alpha
    Monoclonal Antibody for Human PDGF-R-alpha
    Monoclonal Antibody for Human PDGF-R-alpha
    Monoclonal Antibody for Human PDGF-R-alpha
    Protein for Human PDGF-R-alpha
    Protein for Human PDGF-R-alpha
    Protein for Human PDGF-R-alpha
    Protein for Human PDGF-R-alpha

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor."
      Claesson-Welsh L. , Eriksson A. , Westermark B. , Heldin C.H.
      Proc. Natl. Acad. Sci. U.S.A.86:4917-4921(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH PDGFA AND PDGFB
      tissue: Foreskin.
    2. 2.
      "Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes."
      Matsui T. , Heidaran M. , Miki T. , Popescu N. , la Rochelle W. , Kraus M. , Pierce J. , Aaronson S.
      Science243:800-804(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);AUTOPHOSPHORYLATION;TISSUE SPECIFICITY;INTERACTION WITH PDGFA AND PDGFB
      tissue: Brain.
    3. 3.
      "Structure, organization, and transcription units of the human alpha-platelet-derived growth factor receptor gene, PDGFRA."
      Kawagishi J. , Ku T.
      Genomics30:224-232(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Blood.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT PRO-478
      tissue: Lung.
      tissue: Trachea.
    5. 5.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3);VARIANT PRO-478
      tissue: Placenta.
    7. 7.
      "Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome."
      Griffin J.H. , Leung J. , Bruner R.J. , Caligiuri M.A. , Briesewitz R.
      Proc. Natl. Acad. Sci. U.S.A.100:7830-7835(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 579-1089;DISEASE;IDENTIFICATION BY MASS SPECTROMETRY OF FIP1L1-PDGFRA FUSION PROTEIN
      tissue: Eosinophil.
    8. 8.
      "Receptor tyrosine kinases expressed in metastatic colon cancer."
      Craven R.J. , Xu L.H. , Weiner T.M. , Fridell Y.-W. , Dent G.A. , Srivastava S. , Varnum B. , Liu E.T. , Cance W.G.
      Int. J. Cancer60:791-797(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 823-876;TISSUE SPECIFICITY
      tissue: Colon tumor.
    9. 9.
      "Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways."
      Matsui T. , Pierce J.H. , Fleming T.P. , Greenberger J.S. , LaRochelle W.J. , Ruggiero M. , Aaronson S.A.
      Proc. Natl. Acad. Sci. U.S.A.86:8314-8318(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS PDGFA AND PDGFB RECEPTOR IN CELL PROLIFERATION AND CHEMOTAXIS;SUBCELLULAR LOCATION
    10. 10.
      "Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors."
      Anderson D. , Koch C.A. , Grey L. , Ellis C. , Moran M.F. , Pawson T.
      Science250:979-982(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PLCG1 AND SRC
    11. 11.
      "Platelet-derived growth factor (PDGF) stimulates PDGF receptor subunit dimerization and intersubunit trans-phosphorylation."
      Kelly J.D. , Haldeman B.A. , Grant F.J. , Murray M.J. , Seifert R.A. , Bowen-Pope D.F. , Cooper J.A. , Kazlauskas A.
      J. Biol. Chem.266:8987-8992(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PDGFRA; PDGFA AND PDGFB;FUNCTION AS RECEPTOR FOR PDGFA AND PDGFB;AUTOPHOSPHORYLATION
    12. 12.
      "Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction."
      Yu J.C. , Heidaran M.A. , Pierce J.H. , Gutkind J.S. , Lombardi D. , Ruggiero M. , Aaronson S.A.
      Mol. Cell. Biol.11:3780-3785(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS PDGFB RECEPTOR IN CHEMOTAXIS; CELL PROLIFERATION; PHOSPHORYLATION OF PLCG1; ACTIVATION OF PHOSPHATIDYLINOSITOL 3-KINASE AND REGULATION OF PHOSPHATIDYLINOSITOL METABOLISM;INTERACTION WITH PIK3R;PHOSPHORYLATION AT TYR-731 AND TYR-742;MUTAGENESIS OF TYR-731 AND TYR-742
    13. 13.
      "Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta PDGF receptor."
      Fretto L.J. , Snape A.J. , Tomlinson J.E. , Seroogy J.J. , Wolf D.L. , LaRochelle W.J. , Giese N.A.
      J. Biol. Chem.268:3625-3631(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PDGFA AND PDGFB
    14. 14.
      "Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor."
      Vassbotn F.S. , Havnen O.K. , Heldin C.H. , Holmsen H.
      J. Biol. Chem.269:13874-13879(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS PDGFA RECEPTOR IN REGULATION OF PLATELET ACTIVATION;SUBCELLULAR LOCATION;AUTOPHOSPHORYLATION;TISSUE SPECIFICITY
    15. 15.
      "Demonstration of functionally different interactions between phospholipase C-gamma and the two types of platelet-derived growth factor receptors."
      Eriksson A. , Naanberg E. , Roennstrand L. , Engstroem U. , Hellman U. , Rupp E. , Carpenter G. , Heldin C.H. , Claesson-Welsh L.
      J. Biol. Chem.270:7773-7781(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-988 AND TYR-1018;INTERACTION WITH PLCG1
    16. 16.
      "Maximal PDGF-induced lung fibroblast chemotaxis requires PDGF receptor-alpha."
      Osornio-Vargas A.R. , Lindroos P.M. , Coin P.G. , Badgett A. , Hernandez-Rodriguez N.A. , Bonner J.C.
      Am. J. Physiol.271:L93-L99(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PROMOTING CHEMOTAXIS
    17. 17.
      "Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors."
      Yokote K. , Margolis B. , Heldin C.H. , Claesson-Welsh L.
      J. Biol. Chem.271:30942-30949(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB7 AND PIK3R1
    18. 18.
      "Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation."
      Bazenet C.E. , Gelderloos J.A. , Kazlauskas A.
      Mol. Cell. Biol.16:6926-6936(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF PTPN11; ACTIVATION OF HRAS AND REGULATION OF CELL PROLIFERATION;PHOSPHORYLATION AT TYR-720;INTERACTION WITH GRB2; PTPN11; PLCG1 AND PIK3R1;AUTOPHOSPHORYLATION;MUTAGENESIS OF TYR-720
    19. 19.
      "Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation."
      Matsumoto T. , Yokote K. , Take A. , Takemoto M. , Asaumi S. , Hashimoto Y. , Matsuda M. , Saito Y. , Mori S.
      Biochem. Biophys. Res. Commun.270:28-33(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CRK;PHOSPHORYLATION AT TYR-762;MUTAGENESIS OF TYR-762
    20. 20.
      "Shf, a Shb-like adapter protein, is involved in PDGF-alpha-receptor regulation of apoptosis."
      Lindholm C.K. , Frantz J.D. , Shoelson S.E. , Welsh M.
      Biochem. Biophys. Res. Commun.278:537-543(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SHF;PHOSPHORYLATION AT TYR-720
    21. 21.
      "Platelet-derived-growth-factor-induced signalling in human platelets: phosphoinositide-3-kinase-dependent inhibition of platelet activation."
      Selheim F. , Fukami M.H. , Holmsen H. , Vassbotn F.S.
      Biochem. J.350:469-475(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PLATELET ACTIVATION
    22. 22.
      "Src family kinases negatively regulate platelet-derived growth factor alpha receptor-dependent signaling and disease progression."
      Rosenkranz S. , Ikuno Y. , Leong F.L. , Klinghoffer R.A. , Miyake S. , Band H. , Kazlauskas A.
      J. Biol. Chem.275:9620-9627(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACTIVATION OF MAPK1/ERK2 AND/OR MAPK3/ERK1;DEGRADATION;PHOSPHORYLATION AT TYR-572 AND TYR-574;MUTAGENESIS OF TYR-572 AND TYR-574
    23. 23.
      "Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor."
      Gilbertson D.G. , Duff M.E. , West J.W. , Kelly J.D. , Sheppard P.O. , Hofstrand P.D. , Gao Z. , Shoemaker K. , Bukowski T.R. , Moore M. , Feldhaus A.L. , Humes J.M. , Palmer T.E. , Hart C.E.
      J. Biol. Chem.276:27406-27414(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A RECEPTOR FOR PDGFC;INTERACTION WITH PDGFC
    24. 24.
      "The role of c-Src in platelet-derived growth factor alpha receptor internalization."
      Avrov K. , Kazlauskas A.
      Exp. Cell Res.291:426-434(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH SRC;MUTAGENESIS OF TYR-572 AND TYR-574
    25. 25.
      "A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome."
      Cools J. , DeAngelo D.J. , Gotlib J. , Stover E.H. , Legare R.D. , Cortes J. , Kutok J. , Clark J. , Galinsky I. , Griffin J.D. , Cross N.C. , Tefferi A. , Malone J. , Alam R. , Schrier S.L. , Schmid J. , Rose M. , Vandenberghe P. , more...
      N. Engl. J. Med.348:1201-1214(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN HES
    26. 26.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF AKT1; MAP KINASES; STAT1 AND STAT3;INVOLVEMENT IN GIST;VARIANTS ASP-561; VAL-842; 842-ASP--HIS-845 DEL AND 845-HIS--PRO-448 DEL;CHARACTERIZATION OF VARIANTS ASP-561; VAL-842; 842-ASP--HIS-845 DEL AND 845-HIS--PRO-448 DEL
    27. 27.
      "PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib."
      Corless C.L. , Schroeder A. , Griffith D. , Town A. , McGreevey L. , Harrell P. , Shiraga S. , Bainbridge T. , Morich J. , Heinrich M.C.
      J. Clin. Oncol.23:5357-5364(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN GIST;VARIANTS ASP-561; LYS-659; TYR-842; VAL-842; 842-ASP--HIS-845 DEL 845-HIS--PRO-448 DEL AND CYS-849;CHARACTERIZATION OF VARIANTS ASP-561; LYS-659; TYR-842; VAL-842; 842-ASP--HIS-845 DEL 845-HIS--PRO-448 DEL AND CYS-849;ENZYME REGULATION
    28. 28.
      "PI3-kinase/Akt-dependent antiapoptotic signaling by the PDGF alpha receptor is negatively regulated by Src family kinases."
      Vantler M. , Huntgeburth M. , Caglayan E. , Ten Freyhaus H. , Schnabel P. , Rosenkranz S.
      FEBS Lett.580:6769-6776(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL SURVIVAL
    29. 29.
      "The glycoprotein B disintegrin-like domain binds beta 1 integrin to mediate cytomegalovirus entry."
      Feire A.L. , Roy R.M. , Manley K. , Compton T.
      J. Virol.84:10026-10037(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HHV-5 GB
    30. 30.
      "Novel imatinib-sensitive PDGFRA-activating point mutations in hypereosinophilic syndrome induce growth factor independence and leukemia-like disease."
      Elling C. , Erben P. , Walz C. , Frickenhaus M. , Schemionek M. , Stehling M. , Serve H. , Cross N.C. , Hochhaus A. , Hofmann W.K. , Berdel W.E. , Muller-Tidow C. , Reiter A. , Koschmieder S.
      Blood117:2935-2943(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF STAT 5A AND/OR STAT5B;ROLE IN HYPEREOSINOPHILIC SYNDROME;VARIANTS GLY-481; PRO-507; MET-562; ARG-570; GLN-650; SER-659; PRO-705; GLY-748 AND SER-849;CHARACTERIZATION OF VARIANTS GLY-481; PRO-507; MET-562; ARG-570; GLN-650; SER-659; PRO-705; GLY-748 AND SER-849;ENZYME REGULATION
    31. 31.
      "The Casitas B lineage lymphoma (Cbl) mutant G306E enhances osteogenic differentiation in human mesenchymal stromal cells in part by decreased Cbl-mediated platelet-derived growth factor receptor alpha and fibroblast growth factor receptor 2 ubiquitination."
      Severe N. , Miraoui H. , Marie P.J.
      J. Biol. Chem.286:24443-24450(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL DIFFERENTIATION;UBIQUITINATION
    32. 32.
      "The low frequency of clinical resistance to PDGFR inhibitors in myeloid neoplasms with abnormalities of PDGFRA might be related to the limited repertoire of possible PDGFRA kinase domain mutations in vitro."
      von Bubnoff N. , Gorantla S.P. , Engh R.A. , Oliveira T.M. , Thone S. , Aberg E. , Peschel C. , Duyster J.
      Oncogene30:933-943(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ROLE IN DISEASE;CHARACTERIZATION OF VARIANT VAL-842;ENZYME REGULATION
    33. 33.
      "Signal transduction via platelet-derived growth factor receptors."
      Heldin C.H. , Ostman A. , Ronnstrand L.
      Biochim. Biophys. Acta1378:F79-113(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON SIGNALING AND AUTOPHOSPHORYLATION
    34. 34.
      "PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma."
      Ostman A.
      Cytokine Growth Factor Rev.15:275-286(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ROLE IN DISEASE AND ENZYME REGULATION
    35. 35.
      "PDGF receptors as targets in tumor treatment."
      Ostman A. , Heldin C.H.
      Adv. Cancer Res.97:247-274(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ROLE IN DISEASE AND ENZYME REGULATION
    36. 36.
      "Role of platelet-derived growth factors in physiology and medicine."
      Andrae J. , Gallini R. , Betsholtz C.
      Genes Dev.22:1276-1312(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION IN DEVELOPMENT AND DISEASE; LIGANDS AND SIGNALING PATHWAYS
    37. 37.
      "Structural determinants of the Na+/H+ exchanger regulatory factor interaction with the beta 2 adrenergic and platelet-derived growth factor receptors."
      Karthikeyan S. , Leung T. , Ladias J.A.A.
      J. Biol. Chem.277:18973-18978(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 1185-1189 IN COMPLEX WITH SLC9A3R1 AND PDGFRB
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