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Index > Protein center > LTA(Gene name) > Human
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  • LTA (Gene name),
  • Lymphotoxin-alpha (Protein name ),  TNFB_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    LTA(TNFB;TNFSF1);
    Protein name:
    Lymphotoxin-alpha(LT-alpha);
    Alternative:
    Tumor necrosis factor ligand superfamily member 1;TNF-beta;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits.
    Function:
    Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
    Subcellular Location:
    Secreted Membrane The homotrimer is secreted. The heterotrimer is membrane-associated.
    Protein Attributes:
    Sequence length:
    205
    Sequence:
    50:
    MTPPERLFLP | RVCGTTLHLL | LLGLLLVLLP | GAQGLPGVGL | TPSAAQTARQ | 
    100:
    HPKMHLAHST | LKPAAHLIGD | PSKQNSLLWR | ANTDRAFLQD | GFSLSNNSLL | 
    150:
    VPTSGIYFVY | SQVVFSGKAY | SPKATSSPLY | LAHEVQLFSS | QYPFHVPLLS | 
    200:
    SQKMVYPGLQ | EPWLHSMYHG | AAFQLTQGDQ | LSTHTDGIPH | LVLSPSTVFF | 
    205:
    GAFAL
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    UniGene:
    String:
    SMR:
    MIM:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human LT-alpha
    Cat.:
    E0134h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human LT-alpha
    Cat.:
    E0134m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human LT-alpha
    Cat.:
    E0134p
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human LT-alpha
    Cat.:
    E0134b
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human LT-alpha
    Cat.:
    E0134r
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human LT-alpha
    Cat.:
    E0134d
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human LT-alpha
    MSDS:
    Please sign in first.
    CLIA Kit for Human LT-alpha
    MSDS:
    Please sign in first.
    CLIA Kit for Human LT-alpha
    Cat.:
    U0134d
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human LT-alpha
    Cat.:
    U0134r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human LT-alpha
    Cat.:
    U0134b
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human LT-alpha
    Cat.:
    U0134p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human LT-alpha
    Cat.:
    U0134m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human LT-alpha
    Cat.:
    U0134h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    Polyclonal Antibody for Human LT-alpha
    Cat.:
    P0134Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human LT-alpha
    Polyclonal Antibody for Human LT-alpha
    Polyclonal Antibody for Human LT-alpha
    Cat.:
    P0134Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human LT-alpha
    Polyclonal Antibody for Human LT-alpha
    Cat.:
    P0134Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human LT-alpha
    Monoclonal Antibody for Human LT-alpha
    Monoclonal Antibody for Human LT-alpha
    Monoclonal Antibody for Human LT-alpha
    Monoclonal Antibody for Human LT-alpha
    Monoclonal Antibody for Human LT-alpha
    Monoclonal Antibody for Human LT-alpha
    Monoclonal Antibody for Human LT-alpha
    Protein for Human LT-alpha
    Protein for Human LT-alpha
    Protein for Human LT-alpha
    Protein for Human LT-alpha
    Protein for Human LT-alpha
    Protein for Human LT-alpha
    Protein for Human LT-alpha

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    Precision
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "Structure and chromosomal localization of the human lymphotoxin gene."
      Nedwin G.E. , Jarrett-Nedwin J. , Smith D.H. , Naylor S.L. , Sakaguchi A.Y. , Goeddel D.V. , Gray P.W.
      J. Cell. Biochem.29:171-181(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Cloning and expression of human lymphotoxin mRNA derived from a human T cell hybridoma."
      Kobayashi Y. , Miyamoto D. , Asada M. , Obinata M. , Osawa T.
      J. Biochem.100:727-733(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      "Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity."
      Gray P.W. , Aggarwal B.B. , Benton C.V. , Bringman T.S. , Henzel W.J. , Jarrett J.A. , Leung D.W. , Moffat B. , Ng P. , Svedersky L.P. , Palladino M.A. , Nedwin G.E.
      Nature312:721-724(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    5. 5.
      "Nucleotide sequence of a cDNA encoding human tumor necrosis factor beta from B lymphoblastoid cell RPMI 1788."
      Matsuyama N. , Okawa N. , Tsukii Y. , Endo T. , Kaji A.
      FEBS Lett.302:141-144(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    6. 6.
      "Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment."
      Iris F.J.M. , Bougueleret L. , Prieur S. , Caterina D. , Primas G. , Perrot V. , Jurka J. , Rodriguez-Tome P. , Claverie J.-M. , Dausset J. , Cohen D.
      Nat. Genet.3:137-145(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    7. 7.
      "A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC."
      Neville M.J. , Campbell R.D.
      J. Immunol.162:4745-4754(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    8. 8.
      "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
      Xie T. , Rowen L. , Aguado B. , Ahearn M.E. , Madan A. , Qin S. , Campbell R.D. , Hood L.
      Genome Res.13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
      Shiina S. , Tamiya G. , Oka A. , Inoko H.
      Submitted (1999-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      SeattleSNPs variation discovery resource
      Submitted (2001-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ARG-13; PRO-51 AND ASN-60
    11. 11.
      NIEHS SNPs program
      Submitted (2003-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ARG-13; PRO-51 AND ASN-60
    12. 12.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ARG-13
      tissue: Lymph.
    13. 13.
      "Natural human tumor necrosis factor beta (lymphotoxin). Variable O-glycosylation at Thr7, proteolytic processing, and allelic variation."
      Voigt C.G. , Maurer-Fogy I. , Adolf G.R.
      FEBS Lett.314:85-88(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;GLYCOSYLATION AT THR-41 AND ASN-96;VARIANT ASN-60
    14. 14.
      "The structure of human lymphotoxin (tumor necrosis factor-beta) at 1.9-A resolution."
      Eck M.J. , Ultsch M. , Rinderknecht E. , de Vos A.M. , Sprang S.R.
      J. Biol. Chem.267:2119-2122(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS)
    15. 15.
      "Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation."
      Banner D.W. , D'Arcy A. , Janes W. , Gentz R. , Schoenfeld H.-J. , Broger C. , Loetscher H. , Lesslauer W.
      Cell73:431-445(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 61-205 OF COMPLEX WITH TNFR1
    16. 16.
      "Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production."
      Messer G. , Spengler U. , Jung M.C. , Honold G. , Bloemer K. , Pape G.R. , Riethmueller G. , Weiss E.H.
      J. Exp. Med.173:209-219(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASN-60
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PRO-125
    18. 18.
      "Cytokine gene polymorphisms: association with psoriatic arthritis susceptibility and severity."
      Balding J. , Kane D. , Livingstone W. , Mynett-Johnson L. , Bresnihan B. , Smith O. , FitzGerald O.
      Arthritis Rheum.48:1408-1413(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN PSORIATIC ARTHRITIS SUSCEPTIBILITY
    19. 19.
      "Stepwise replication identifies a low-producing lymphotoxin-alpha allele as a major risk factor for early-onset leprosy."
      Alcaies A. , Alter A. , Antoni G. , Orlova M. , Nguyen V.T. , Singh M. , Vanderborght P.R. , Katoch K. , Mira M.T. , Vu H.T. , Ngyuen T.H. , Nguyen N.B. , Moraes M. , Mehra N. , Schurr E. , Abel L.
      Nat. Genet.39:517-522(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN LPRS4
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