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Index > Protein center > Txnip(Gene name) > Mouse
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  • Txnip (Gene name),
  • Thioredoxin-interacting protein (Protein name ),  TXNIP_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Txnip(Vdup1);
    Protein name:
    Thioredoxin-interacting protein;
    Alternative:
    Vitamin D3 up-regulated protein 1;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1. Interacts (via C-terminus) with ITCH (via WW domains).
    Function:
    May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    397
    Sequence:
    50:
    MVMFKKIKSF | EVVFNDPEKV | YGSGEKVAGR | VIVEVCEVTR | VKAVRILACG | 
    100:
    VAKVLWMQGS | QQCKQTLDYL | RYEDTLLLEE | QPTAGENEMV | IMRPGNKYEY | 
    150:
    KFGFELPQGP | LGTSFKGKYG | CVDYWVKAFL | DRPSQPTQEA | KKNFEVMDLV | 
    200:
    DVNTPDLMAP | VSAKKEKKVS | CMFIPDGRVS | VSARIDRKGF | CEGDDISIHA | 
    250:
    DFENTCSRIV | VPKAAIVARH | TYLANGQTKV | FTQKLSSVRG | NHIISGTCAS | 
    300:
    WRGKSLRVQK | IRPSILGCNI | LKVEYSLLIY | VSVPGSKKVI | LDLPLVIGSR | 
    350:
    SGLSSRTSSM | ASRTSSEMSW | IDLNIPDTPE | APPCYMDIIP | EDHRLESPTT | 
    397:
    PLLDDVDDSQ | DSPIFMYAPE | FQFMPPPTYT | EVDPCVLNNN | NNNNNVQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    SMR:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Thioredoxin-interacting protein
    Cat.:
    E1162h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Thioredoxin-interacting protein
    Cat.:
    E1162p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse Thioredoxin-interacting protein
    Cat.:
    E1162m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse Thioredoxin-interacting protein
    Cat.:
    E1162r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Thioredoxin-interacting protein
    Cat.:
    U1162p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Thioredoxin-interacting protein
    Cat.:
    U1162m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Thioredoxin-interacting protein
    Cat.:
    U1162r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Thioredoxin-interacting protein
    Cat.:
    U1162h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Mouse Thioredoxin-interacting protein
    Cat.:
    P1162Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Thioredoxin-interacting protein
    Polyclonal Antibody for Mouse Thioredoxin-interacting protein
    Cat.:
    P1162Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Thioredoxin-interacting protein
    Cat.:
    P1162Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Thioredoxin-interacting protein
    Monoclonal Antibody for Mouse Thioredoxin-interacting protein
    Monoclonal Antibody for Mouse Thioredoxin-interacting protein
    Monoclonal Antibody for Mouse Thioredoxin-interacting protein
    Protein for Mouse Thioredoxin-interacting protein
    Protein for Mouse Thioredoxin-interacting protein
    Protein for Mouse Thioredoxin-interacting protein
    Protein for Mouse Thioredoxin-interacting protein

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    Citations
    [1].
    Seok Kyo Seo, Hyo In Yang, Kyung Eun Lee, Hye Yeon Kim, SiHyun Cho, Young Sik Choi and Byung Seok Lee
    References
    1. 1.
      "Vitamin D3 up-regulated protein 1 mediates oxidative stress via suppressing the thioredoxin function."
      Junn E. , Han S.H. , Im J.Y. , Yang Y. , Cho E.W. , Um H.D. , Kim D.K. , Lee K.W. , Han P.L. , Rhee S.G. , Choi I.
      J. Immunol.164:6287-6295(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);INTERACTION WITH TXN;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    2. 2.
      "Cloning, genetic characterization, and chromosomal mapping of the mouse VDUP1 gene."
      Ludwig D.L. , Kotanides H. , Le T. , Chavkin D. , Bohlen P. , Witte L.
      Gene269:103-112(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2)
      strain: C57BL/6.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      strain: C57BL/6J.
      strain: NOD.
      tissue: Cerebellum.
      tissue: Lung.
      tissue: Thymus.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      strain: Czech II.
      tissue: Mammary tumor.
    5. 5.
      "Tumor suppressor VDUP1 increases p27(kip1) stability by inhibiting JAB1."
      Jeon J.H. , Lee K.N. , Hwang C.Y. , Kwon K.S. , You K.H. , Choi I.
      Cancer Res.65:4485-4489(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH COPS5
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
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