ELANE ELISA Kit for Human(Homo sapiens) | EIAab.comELANE ELISA Kit for Human(Homo sapiens)

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Index > Protein center > ELANE(Gene name) > Human

ELANE (Gene name),

Neutrophil elastase (Protein name ), ELNE_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

ELANE(ELA2);

Protein name:

Neutrophil elastase;

Alternative:

Elastase-2;Bone marrow serine protease;Medullasin;Human leukocyte elastase(HLE);PMN elastase;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with NOTCH2NL.

Function:

Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

267

Sequence:

50:

100:

150:

200:

250:

267:

DNPCPHPRDP | DPASRTH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P08246

Pfam:

PF00089

String:

P08246

MIM:

130130

KEGG:

hsa:1991

STRING:

9606.ENSP00000263621

UniGene:

Hs.99863

Uniprot:

P08246

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ELISA Kit for Human Neutrophil elastase

Cat.:

E0181h

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96T

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ELISA Kit for Human Neutrophil elastase

Cat.:

E0181m

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96T

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ELISA Kit for Human Neutrophil elastase

Cat.:

E0181r

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Packing:

96T

CLIA Kit for Human Neutrophil elastase

Cat.:

U0181m

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96T

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CLIA Kit for Human Neutrophil elastase

Cat.:

U0181h

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Looking for manual.

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96T

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CLIA Kit for Human Neutrophil elastase

Cat.:

U0181r

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96T

Polyclonal Antibody for Human Neutrophil elastase

Cat.:

P0181Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Neutrophil elastase

Cat.:

P0181Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Neutrophil elastase

Cat.:

P0181Rb-m

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40ug/0.2ml

Monoclonal Antibody for Human Neutrophil elastase

Protein for Human Neutrophil elastase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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Citations

[1].

"Evaluation of Serum Level of Neutrophil Elastase, Superoxide Dismutase and Nitric Oxide in COPD Patients and its Correlation with Lung Function Test"

Pawar R S, Abhang S A.

From:International Journal of Biochemistry Research & Review

References

1.

"Nucleotide sequence of human bone marrow serine protease (medullasin) gene."
Nakamura H. , Okano K. , Aoki Y. , Shimizu H. , Naruto M.
Nucleic Acids Res.15:9601-9601(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.

"Structure of the human neutrophil elastase gene."
Takahashi H. , Nukiwa T. , Yoshimura K. , Quick C.D. , States D.J. , Holmes M.D. , Whang-Peng J. , Knutsen T. , Crystal R.G.
J. Biol. Chem.263:14739-14747(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"The human neutrophil elastase gene. Analysis of the nucleotide sequence reveals three distinct classes of repetitive DNA."
Farley D. , Travis J. , Salvesen G.
Biol. Chem. Hoppe-Seyler370:737-744(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Functional expression of human leukocyte elastase (HLE)/medullasin in eukaryotic cells."
Okano K. , Aoki Y. , Shimizu H. , Naruto M.
Biochem. Biophys. Res. Commun.167:1326-1332(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
5.

NIEHS SNPs program
Submitted (2004-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ILE-219; LEU-257 AND LEU-262
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lung.
7.

"Molecular cloning of complementary DNA for human medullasin: an inflammatory serine protease in bone marrow cells."
Okano K. , Aoki Y. , Sakurai T. , Kajitani M. , Kanai S. , Shimazu T. , Shimizu H. , Naruto M.
J. Biochem.102:13-16(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-267
8.

"Primary structure of human neutrophil elastase."
Sinha S. , Watorek W. , Karr S. , Giles J. , Bode W. , Travis J.
Proc. Natl. Acad. Sci. U.S.A.84:2228-2232(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 30-247
9.

Travis J. , Giles P.J. , Porcelli L. , Reilly C.F. , Baugh R. , Powers J.

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PRELIMINARY PROTEIN SEQUENCE OF 30-103
10.

"Antibiotic proteins of human polymorphonuclear leukocytes."
Gabay J.E. , Scott R.W. , Campanelli D. , Griffith J. , Wilde C. , Marra M.N. , Seeger M. , Nathan C.F.
Proc. Natl. Acad. Sci. U.S.A.86:5610-5614(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 30-49
11.

"Use of proteinase 3 purified by reverse phase HPLC to detect autoantibodies in systemic vasculitis."
Gaskin G. , Kendal H. , Coulthart A. , Turner N. , Pusey C.D.
J. Immunol. Methods180:25-33(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 30-49
tissue: Neutrophil.
12.

"Myelomonocytic cell lineage expression of the neutrophil elastase gene."
Takahashi H. , Nukiwa T. , Basset P. , Cystal R.G.
J. Biol. Chem.263:2543-2547(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 75-267
13.

"Molecular cloning of human neutrophil elastase."
Farley D. , Salvesen G.S. , Travis J.
Biol. Chem. Hoppe-Seyler369:3-7(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 123-267
14.

"The primary structure and elastinolytic activity of medullasin (a serine protease of bone marrow)."
Aoki Y. , Hase T.
Biochem. Biophys. Res. Commun.178:501-506(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 262-267
15.

"Human leukocyte elastase and cathepsin G are specific inhibitors of C5a-dependent neutrophil enzyme release and chemotaxis."
Tralau T. , Meyer-Hoffert U. , Schroder J.M. , Wiedow O.
Exp. Dermatol.13:316-325(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
16.

"A novel notch protein, N2N, targeted by neutrophil elastase and implicated in hereditary neutropenia."
Duan Z. , Li F.-Q. , Wechsler J. , Meade-White K. , Williams K. , Benson K.F. , Horwitz M.
Mol. Cell. Biol.24:58-70(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NOTCH2NL;CHARACTERIZATION OF VARIANT CH GLN-220
17.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-88 AND ASN-173
tissue: Liver.
18.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.

"Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution."
Navia M.A. , McKeever B.M. , Springer J.P. , Lin T.-Y. , Williams H.R. , Fluder E.M. , Dorn C.P. , Hoogsteen K.
Proc. Natl. Acad. Sci. U.S.A.86:7-11(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.84 ANGSTROMS)
20.

"The refined 2.3-A crystal structure of human leukocyte elastase in a complex with a valine chloromethyl ketone inhibitor."
Wei A.-Z. , Mayr I. , Bode W.
FEBS Lett.234:367-373(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS)
21.

"X-ray crystal structure of the complex of human leukocyte elastase (PMN elastase) and the third domain of the turkey ovomucoid inhibitor."
Bode W. , Wei A.-Z. , Huber R. , Meyer E. , Travis J. , Neumann S.
EMBO J.5:2453-2458(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS)
22.

"Mutations in ELA2, encoding neutrophil elastase, define a 21-day biological clock in cyclic haematopoiesis."
Horwitz M. , Benson K.F. , Person R.E. , Aprikyan A.G. , Dale D.C.
Nat. Genet.23:433-436(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CH VAL-61; PHE-206 AND GLN-220
23.

"Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia."
Dale D.C. , Person R.E. , Bolyard A.A. , Aprikyan A.G. , Bos C. , Bonilla M.A. , Boxer L.A. , Kannourakis G. , Zeidler C. , Welte K. , Benson K.F. , Horwitz M.
Blood96:2317-2322(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SCN1 THR-57; THR-60; SER-71; MET-101; LEU-126; LEU-139; VAL-210 AND ARG-214;VARIANT CH LEU-139
24.

"Mutations in the ELA2 gene encoding neutrophil elastase are present in most patients with sporadic severe congenital neutropenia but only in some patients with the familial form of the disease."
Ancliff P.J. , Gale R.E. , Liesner R. , Hann I.M. , Linch D.C.
Blood98:2645-2650(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SCN1 TYR-55; GLU-85; PRO-GLN-LEU-123 INS; LEU-126; SER-151; 190-VAL--PHE-199 DEL AND ARG-205
25.

"Paternal mosaicism proves the pathogenic nature of mutations in neutrophil elastase in severe congenital neutropenia."
Ancliff P.J. , Gale R.E. , Watts M.J. , Liesner R. , Hann I.M. , Strobel S. , Linch D.C.
Blood100:707-709(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SCN1 ARG-71
26.

"Mutations in the ELA2 gene correlate with more severe expression of neutropenia: a study of 81 patients from the French Neutropenia Register."
Bellanne-Chantelot C. , Clauin S. , Leblanc T. , Cassinat B. , Rodrigues-Lima F. , Beaufils S. , Vaury C. , Barkaoui M. , Fenneteau O. , Maier-Redelsperger M. , Chomienne C. , Donadieu J.
Blood103:4119-4125(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SCN1 LEU-42; PRO-47; LEU-53; PRO-81; PRO-84; PRO-121; PRO-127; LEU-139; PRO-152 AND 190-VAL--199-PHE DEL;VARIANTS CH LEU-43; PHE-46; MET-82; LEU-126; LEU-139; 190-VAL--199-PHE DEL; ILE-219 AND GLN-220;VARIANT LEU-262
27.

"Double de novo mutations of ELA2 in cyclic and severe congenital neutropenia."
Salipante S.J. , Benson K.F. , Luty J. , Hadavi V. , Kariminejad R. , Kariminejad M.H. , Rezaei N. , Horwitz M.S.
Hum. Mutat.28:874-881(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SCN1 LEU-98 AND LEU-101;CHARACTERIZATION OF VARIANTS SCN1 LEU-98 AND LEU-101
28.

"A novel mutation Ala57Val of the ELA2 gene in a Korean boy with severe congenital neutropenia."
Lee S.T. , Yoon H.S. , Kim H.J. , Lee J.H. , Park J.H. , Kim S.H. , Seo J.J. , Im H.J.
Ann. Hematol.88:593-595(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SCN1 VAL-57
29.

"Homozygous HAX1 mutations in severe congenital neutropenia patients with sporadic disease: a novel mutation in two unrelated British kindreds."
Smith B.N. , Ancliff P.J. , Pizzey A. , Khwaja A. , Linch D.C. , Gale R.E.
Br. J. Haematol.144:762-770(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SCN1 ARG-44; CYS-46; TYR-53; ARG-85; ARG-203 AND CYS-203
30.

"Ela2 mutations and clinical manifestations in familial congenital neutropenia."
Shiohara M. , Shigemura T. , Saito S. , Tanaka M. , Yanagisawa R. , Sakashita K. , Asada H. , Ishii E. , Koike K. , Chin M. , Kobayashi M. , Koike K.
J. Pediatr. Hematol. Oncol.31:319-324(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SCN1 LEU-42; PRO-81; MET-101 AND LEU-126
31.

"Digenic mutations in severe congenital neutropenia."
Germeshausen M. , Zeidler C. , Stuhrmann M. , Lanciotti M. , Ballmaier M. , Welte K.
Haematologica95:1207-1210(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SCN1 VAL-25 AND THR-166
32.

"Pegfilgrastim in children with severe congenital neutropenia."
Fioredda F. , Calvillo M. , Lanciotti M. , Lanza T. , Giunti L. , Castagnola E. , Lorenzi I. , Tonelli R. , Ghezzi P. , Dufour C.
Pediatr. Blood Cancer54:465-467(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SCN1 PRO-59 AND GLU-235
33.

"Severe congenital neutropenia in a multigenerational family with a novel neutrophil elastase (ELANE) mutation."
van de Vosse E. , Verhard E.M. , Tool A.J. , de Visser A.W. , Kuijpers T.W. , Hiemstra P.S. , van Dissel J.T.
Ann. Hematol.90:151-158(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SCN1 SER-57
34.

"Four novel ELANE mutations in patients with congenital neutropenia."
Kurnikova M. , Maschan M. , Dinova E. , Shagina I. , Finogenova N. , Mamedova E. , Polovtseva T. , Shagin D. , Shcherbina A.
Pediatr. Blood Cancer57:332-335(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SCN1 THR-131; PRO-152; GLY-235 AND 190-VAL--199-PHE DEL
35.

"The spectrum of ELANE mutations and their implications in severe congenital and cyclic neutropenia."
Germeshausen M. , Deerberg S. , Peter Y. , Reimer C. , Kratz C.P. , Ballmaier M.
Hum. Mutat.34:905-914(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SCN1 VAL-25; LEU-42; LEU-43; GLU-45; PHE-46; ARG-47; PRO-49; SER-55; ARG-56; SER-57; THR-57; VAL-57; PRO-59; 60-ILE-ALA-61 DELINS ARG; THR-60; VAL-61; VAL-65 DEL; 66-MET--HIS-70 DEL; TRP-67; ARG-71; PHE-71; TYR-71; GLY-72; GLY-80; PRO-81; MET-82; PRO-84; GLU-85; LEU-98; MET-98; LEU-101; MET-101; LEU-103; PRO-103; ASN-120; PHE-120; SER-120; PRO-121; HIS-123; ILE-124; LEU-126; ASP-127; THR-131; ASP-136; ARG-139; LEU-139; PHE-151; TRP-151; TYR-151; PRO-152; ASP-153; PRO-153; ARG-156; CYS-156; THR-166; ARG-203; ARG-205; SER-206; GLY-208; ARG-214; GLU-214; ILE-219; GLN-220; PRO-233; GLU-235 AND GLY-235;VARIANTS CH LEU-45; VAL-61; PRO-81; LEU-97; ASN-104; PHE-120; LEU-126; LEU-139; HIS-143; 190-VAL--199-PHE DEL; CYS-203; ILE-209; TRP-210; ILE-219 AND GLN-220;VARIANTS VAL-118; ARG-125; MET-135 AND LEU-257

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