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Index > Protein center > EPHA4(Gene name) > Chicken
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  • EPHA4 (Gene name),
  • Ephrin type-A receptor 4 (Protein name ),  EPHA4_CHICK from NCBI database.
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  • Antigen Annotation
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  • Gene name:
    EPHA4(CEK8);
    Protein name:
    Ephrin type-A receptor 4;
    Alternative:
    EPH-like kinase 8(EK8;cEK8);
    Organism:
    Chicken (Gallus gallus). 
    General Annotation
    Sub Unit:
    Interacts with the src family kinase, p59-Fyn, through the major phosphorylation site at position Tyr-602 (By similarity). Interacts (via PDZ motif) with SIPA1L1 (via PDZ domain); controls neuronal morphology through regulation of the RAP1 (RAP1A or RAP1B) and RAP2 (RAP2A, RAP2B or RAP2C) GTPases.
    Function:
    Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein Early endosome Clustered upon activation and targeted to early endosome.
    Protein Attributes:
    Sequence length:
    986
    Sequence:
    50:
    MAGVPVGALL | PLLVGVCGAV | TGSRVYPANE | VTLLDSRSVQ | GELGWIASPL | 
    100:
    EGGWEEVSIM | DEKNTPIRTY | QVCNVMEPSQ | NNWLRTDWIP | REGAQRVYIE | 
    150:
    IKFTLRDCNS | LPGVMGTCKE | TFNLYYYESN | NDKERFIRES | QFAKIDTIAA | 
    200:
    DESFTQVDIG | DRIMKLNTEV | RDVGPLSKKG | FYLAFQDVGA | CIALVSVRVF | 
    250:
    YKKCPLTVRN | LAQFPDTITG | ADTSSLVEVR | GSCVNNSEEK | DVPKMYCGAD | 
    300:
    GEWLVPIGNC | LCNAGYEERN | GECQACKIGY | YKALSTDVAC | AKCPPHSYSI | 
    350:
    WEGSTSCTCD | RGFFRAENDA | ASMPCTRPPS | APQNLISNVN | ETSVNLEWSA | 
    400:
    PQNKGGRDDI | SYNVVCKRCG | AGEPSHCRSC | GSGVHFSPQQ | NGLKTTKVSI | 
    450:
    TDLLAHTNYT | FEVWAVNGVS | KHNPSQDQAV | SVTVTTNQAA | PSPIALIQAK | 
    500:
    EITRHSVALA | WLEPDRPNGV | ILEYEVKYYE | KDQNERSYRI | VKTASRNTDI | 
    550:
    KGLNPLTSYV | FHVRARTAAG | YGDFSGPFEF | TTNTVPSPII | GDGTNPTVLL | 
    600:
    VSVAGSVVLV | VILIAAFVIS | RRRSKYSKAK | QEADEEKHLN | QGVRTYVDPF | 
    650:
    TYEDPNQAVR | EFAKEIDASC | IKIEKVIGVG | EFGEVCSGRL | KVPGKREICV | 
    700:
    AIKTLKAGYT | DKQRRDFLSE | ASIMGQFDHP | NIIHLEGVVT | KCKPVMIITE | 
    750:
    YMENGSLDAF | LRKNDGRFTV | IQLVGMLRGI | GSGMKYLSDM | SYVHRDLAAR | 
    800:
    NILVNSNLVC | KVSDFGMSRV | LEDDPEAAYT | TRGGKIPIRW | TAPEAIAYRK | 
    850:
    FTSASDVWSY | GIVMWEVMSY | GERPYWDMSN | QDVIKAIEEG | YRLPPPMDCP | 
    900:
    IALHQLMLDC | WQKERSDRPK | FGQIVNMLDK | LIRNPNSLKR | TGSESSRPST | 
    950:
    ALLDPSSPEF | SAVVSVSDWL | QAIKMERYKD | NFTAAGYTTL | EAVVHMNQDD | 
    986:
    LARIGITAIT | HQNKILSSVQ | AMRSQMQQMH | GRMVPV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    Pfam:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Chicken Ephrin type-A receptor 4
    Cat.:
    E0303m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Chicken Ephrin type-A receptor 4
    Cat.:
    E0303h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Chicken Ephrin type-A receptor 4
    Cat.:
    E0303c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Chicken Ephrin type-A receptor 4
    Cat.:
    U0303c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Chicken Ephrin type-A receptor 4
    Cat.:
    U0303m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Chicken Ephrin type-A receptor 4
    Cat.:
    U0303h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Chicken Ephrin type-A receptor 4
    Cat.:
    P0303Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Chicken Ephrin type-A receptor 4
    Polyclonal Antibody for Chicken Ephrin type-A receptor 4
    Cat.:
    P0303Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Chicken Ephrin type-A receptor 4
    Monoclonal Antibody for Chicken Ephrin type-A receptor 4
    Monoclonal Antibody for Chicken Ephrin type-A receptor 4
    Protein for Chicken Ephrin type-A receptor 4
    Protein for Chicken Ephrin type-A receptor 4
    Protein for Chicken Ephrin type-A receptor 4

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    Precision
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    Linearity
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    References
    1. 1.
      "The receptor tyrosine kinase, Cek8, is transiently expressed on subtypes of motoneurons in the spinal cord during development."
      Ohta K. , Nakamura M. , Hirokawa K. , Tanaka S. , Iwama A. , Suda T. , Ando M. , Tanaka H.
      Mech. Dev.54:59-69(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Spinal cord.
    2. 2.
      "Five novel avian Eph-related tyrosine kinases are differentially expressed."
      Sajjadi F.G. , Pasquale E.B.
      Oncogene8:1807-1813(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 138-986
      tissue: Embryo.
    3. 3.
      "The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases."
      Richter M. , Murai K.K. , Bourgin C. , Pak D.T. , Pasquale E.B.
      J. Neurosci.27:14205-14215(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SIPA1L1
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