Gene name:
Epha4 (Sek;Sek1) ;
Protein name:
Ephrin type-A receptor 4 ;
Alternative:
Tyrosine-protein kinase receptor SEK-1 ;Tyrosine-protein kinase receptor MPK-3 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Interacts (phosphorylated at position Tyr-602) with FYN. Interacts (via PDZ motif) with SIPA1L1 (via PDZ domain); controls neuronal morphology through regulation of the RAP1 (RAP1A or RAP1B) and RAP2 (RAP2A, RAP2B or RAP2C) GTPases. Interacts with CDK5, CDK5R1 and NGEF; upon activation by EFNA1 induces NGEF phosphorylation by the kinase CDK5. Interacts with CHN1; effector of EPHA4 in axon guidance linking EPHA4 activation to RAC1 regulation.
Function:
Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. Beside its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium.
Subcellular Location:
Cell membrane
Single-pass type I membrane protein
Cell projection
axon
Cell projection
dendrite
Cell junction
synapse
postsynaptic cell membrane
postsynaptic density
Early endosome
Clustered upon activation and targeted to early endosome.
Protein Attributes:
50:
MAGIFYFILF | SFLFGICDAV | TGSRVYPANE | VTLLDSRSVQ | GELGWIASPL |
100:
EGGWEEVSIM | DEKNTPIRTY | QVCNVMEASQ | NNWLRTDWIT | REGAQRVYIE |
150:
IKFTLRDCNS | LPGVMGTCKE | TFNLYYYESD | NDKERFIRES | QFGKIDTIAA |
200:
DESFTQVDIG | DRIMKLNTEI | RDVGPLSKKG | FYLAFQDVGA | CIALVSVRVF |
250:
YKKCPLTVRN | LAQFPDTITG | ADTSSLVEVR | GSCVNNSEEK | DVPKMYCGAD |
300:
GEWLVPIGNC | LCNAGHEEQN | GECQACKIGY | YKALSTDASC | AKCPPHSYSV |
350:
WEGATSCTCD | RGFFRADNDA | ASMPCTRPPS | APLNLISNVN | ETSVNLEWSS |
400:
PQNTGGRQDI | SYNVVCKKCG | AGDPSKCRPC | GSGVHYTPQQ | NGLKTTRVSI |
450:
TDLLAHTNYT | FEIWAVNGVS | KYNPSPDQSV | SVTVTTNQAA | PSSIALVQAK |
500:
EVTRYSVALA | WLEPDRPNGV | ILEYEVKYYE | KDQNERSYRI | VRTAARNTDI |
550:
KGLNPLTSYV | FHVRARTAAG | YGDFSEPLEV | TTNTVPSRII | GDGANSTVLL |
600:
VSVSGSVVLV | VILIAAFVIS | RRRSKYSKAK | QEADEEKHLN | QGVRTYVDPF |
650:
TYEDPNQAVR | EFAKEIDASC | IKIEKVIGVG | EFGEVCSGRL | KVPGKREICV |
700:
AIKTLKAGYT | DKQRRDFLSE | ASIMGQFDHP | NIIHLEGVVT | KCKPVMIITE |
750:
YMENGSLDAF | LRKNDGRFTV | IQLVGMLRGI | GSGMKYLSDM | SYVHRDLAAR |
800:
NILVNSNLVC | KVSDFGMSRV | LEDDPEAAYT | TRGGKIPIRW | TAPEAIAYRK |
850:
FTSASDVWSY | GIVMWEVMSY | GERPYWDMSN | QDVIKAIEEG | YRLPPPMDCP |
900:
IALHQLMLDC | WQKERSDRPK | FGQIVNMLDK | LIRNPNSLKR | TGSESSRPNT |
950:
ALLDPSSPEF | SAVVSVGDWL | QAIKMDRYKD | NFTAAGYTTL | EAVVHMSQDD |
986:
LARIGITAIT | HQNKILSSVQ | AMRTQMQQMH | GRMVPV
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Chicken
ELISA Kit for Mouse Ephrin type-A receptor 4
ELISA Kit for Mouse Ephrin type-A receptor 4
ELISA Kit for Mouse Ephrin type-A receptor 4
CLIA Kit for Mouse Ephrin type-A receptor 4
CLIA Kit for Mouse Ephrin type-A receptor 4
CLIA Kit for Mouse Ephrin type-A receptor 4
Polyclonal Antibody for Mouse Ephrin type-A receptor 4
Polyclonal Antibody for Mouse Ephrin type-A receptor 4
Polyclonal Antibody for Mouse Ephrin type-A receptor 4
Monoclonal Antibody for Mouse Ephrin type-A receptor 4
Monoclonal Antibody for Mouse Ephrin type-A receptor 4
Monoclonal Antibody for Mouse Ephrin type-A receptor 4
Protein for Mouse Ephrin type-A receptor 4
Protein for Mouse Ephrin type-A receptor 4
Protein for Mouse Ephrin type-A receptor 4
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
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C57BL/6 .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Europe PMC ]
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
strain :
C57BL/6J .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
tissue :
Limb .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Cell130:742-753(2007)
[
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[
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN RAC1 REGULATION;FUNCTION IN AXON GUIDANCE;INTERACTION WITH CHN1
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN NEURON MORPHOLOGY;INTERACTION WITH SIPA1L1
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Nat. Neurosci.10:67-76(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN DENDRITIC SPINE MORPHOGENESIS;TOPOLOGY;SUBCELLULAR LOCATION;INTERACTION WITH NGEF
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN AXON GUIDANCE;INTERACTION WITH CHN1;MUTAGENESIS OF VAL-635
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-602;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Brain .
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN MOTOR AND SENSORY AXONS SEGREGATION