EPOR ELISA Kit for Human(Homo sapiens) | EIAab.comEPOR ELISA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > EPOR(Gene name) > Human

EPOR (Gene name),

Erythropoietin receptor (Protein name ), EPOR_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

EPOR;

Protein name:

Erythropoietin receptor(EPO-R);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Forms homodimers on EPO stimulation. The tyrosine-phosphorylated form interacts with several SH2 domain-containing proteins including LYN (By similarity), the adapter protein APS, PTPN6 (By similarity), PTPN11, JAK2, PI3 kinases, STAT5A/B, SOCS3, CRKL (By similarity). Interacts with INPP5D/SHIP1 (By similarity). The N-terminal SH2 domain of PTPN6 binds Tyr-454 and inhibits signaling through dephosphorylation of JAK2 (By similarity). APS binding also inhibits the JAK-STAT signaling. Binding to PTPN11, preferentially through the N-terminal SH2 domain, promotes mitogenesis and phosphorylation of PTPN11 (By similarity). Binding of JAK2 (through its N-terminal) promotes cell-surface expression (By similarity). Interaction with the ubiquitin ligase NOSIP mediates EPO-induced cell proliferation. Interacts with ATXN2L.

Function:

Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.

Subcellular Location:

Isoform EPOR-S Secreted Secreted and located to the cell surface.

Protein Attributes:

Sequence length:

508

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

508:

PPSYVACS

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

SMR:

P19235

STRING:

9606.ENSP00000222139

MIM:

133100

String:

P19235

KEGG:

hsa:2057

Pfam:

PF09067

UniGene:

Hs.631624

Uniprot:

P19235

FOR

ELISA Kit for Human EPO-R

Cat.:

E0027h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human EPO-R

Cat.:

E0027r

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human EPO-R

Cat.:

E0027p

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human EPO-R

Cat.:

E0027m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human EPO-R

Cat.:

E0027d

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human EPO-R

Cat.:

U0027r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human EPO-R

Cat.:

U0027m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human EPO-R

Cat.:

U0027d

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human EPO-R

Cat.:

U0027p

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human EPO-R

Cat.:

U0027h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

Polyclonal Antibody for Human EPO-R

Cat.:

P0027Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human EPO-R

Cat.:

P0027Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human EPO-R

Cat.:

P0027Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human EPO-R

Protein for Human EPO-R

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The gene for the human erythropoietin receptor: analysis of the coding sequence and assignment to chromosome 19p."
Winkelmann J.C. , Penny L.A. , Deaven L.L. , Forget B.G. , Jenkins R.B.
Blood76:24-30(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.

"Human erythropoietin receptor: cloning, expression, and biologic characterization."
Jones S.S. , D'Andrea A.D. , Haines L.L. , Wong G.G.
Blood76:31-35(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM EPOR-F)
tissue: Erythroleukemia.
tissue: Fetal liver.
3.

"Cloning of the human erythropoietin receptor gene."
Noguchi C.T. , Bae K.S. , Chin K. , Wada Y. , Schechter A.N. , Hankins W.D.
Blood78:2548-2556(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue: Placenta.
4.

"The erythropoietin receptor gene: cloning and identification of multiple transcripts in an erythroid cell line OCIM1."
Ehrenman K. , St John T.
Exp. Hematol.19:973-977(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM EPOR-F)
tissue: Erythroleukemia.
5.

"A truncated erythropoietin receptor that fails to prevent programmed cell death of erythroid cells."
Nakamura Y. , Komatsu N. , Nakauchi H.
Science257:1138-1141(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS EPOR-F; EPOR-S AND EPOR-T)
tissue: Bone marrow.
tissue: Megakaryoblast.
6.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM EPOR-F)
tissue: Caudate nucleus.
7.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM EPOR-F)
tissue: Brain.
9.

"Cloning of the gene encoding the human erythropoietin receptor."
Maouche L. , Tournamille C. , Hattab C. , Boffa G. , Cartron J.-P. , Chretien S.
Blood78:2557-2563(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-96
tissue: Placenta.
10.

"Genomic organization of the human erythropoietin receptor gene."
Penny L.A. , Forget B.G.
Genomics11:974-980(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-17
11.

"Isolation of a cDNA encoding a potential soluble receptor for human erythropoietin."
Todokoro K. , Kuramochi S. , Nagasawa T. , Abe T. , Ikawa Y.
Gene106:283-284(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (EPOR-S)
tissue: Erythroid cell.
12.

"Identification of the human erythropoietin receptor region required for Stat1 and Stat3 activation."
Kirito K. , Nakajima K. , Watanabe T. , Uchida M. , Tanaka M. , Ozawa K. , Komatsu N.
Blood99:102-110(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STAT1/STAT3 ACTIVATION;MUTAGENESIS OF TYR-456 AND TYR-468
13.

"Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways."
Tauchi T. , Feng G.-S. , Shen R. , Hoatlin M. , Bagby G.C. Jr. , Kabat D. , Lu L. , Broxmeyer H.E.
J. Biol. Chem.270:5631-5635(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTPN11
14.

"Identification of a critical ligand binding determinant of the human erythropoietin receptor. Evidence for common ligand binding motifs in the cytokine receptor family."
Middleton S.A. , Johnson D.L. , Jin R. , McMahon F.J. , Collins A. , Tullai J. , Gruninger R.H. , Jolliffe L.K. , Mulcahy L.S.
J. Biol. Chem.271:14045-14054(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: LIGAND-BINDING SITE;MUTAGENESIS OF THR-114; SER-115; SER-116; PHE-117; VAL-118; LEU-120; GLU-121; ARG-165; MET-174; SER-176; HIS-177 AND ARG-179
15.

"Increased cell surface expression of C-terminal truncated erythropoietin receptors in polycythemia."
Motohashi T. , Nakamura Y. , Osawa M. , Hiroyama T. , Iwama A. , Shibuya A. , Nakauchi H.
Eur. J. Haematol.67:88-93(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION (ISOFORM EPOR-S)
16.

"A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor."
Hoertner M. , Nielsch U. , Mayr L.M. , Heinrich P.C. , Haan S.
Eur. J. Biochem.269:2516-2526(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SOCS3;MUTAGENESIS OF TYR-454 AND TYR-456
17.

"Erythropoietin receptors associate with a ubiquitin ligase, p33RUL, and require its activity for erythropoietin-induced proliferation."
Friedman A.D. , Nimbalkar D. , Quelle F.W.
J. Biol. Chem.278:26851-26861(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NOSIP
18.

"APS, an adaptor protein containing pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl."
Wakioka T. , Sasaki A. , Mitsui K. , Yokouchi M. , Inoue A. , Komiya S. , Yoshimura A.
Leukemia13:760-767(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;INTERACTION WITH APS
19.

"Cloning and characterization of a family of proteins associated with Mpl."
Meunier C.F. , Bordereaux D. , Porteu F. , Gisselbrecht S. , Chretien S. , Courtois G.
J. Biol. Chem.277:9139-9147(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATXN2L
20.

"Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A."
Livnah O. , Stura E.A. , Johnson D.L. , Middleton S.A. , Mulcahy L.S. , Wrighton N.C. , Dower W.J. , Jolliffe L.K. , Wilson I.A.
Science273:464-471(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 34-244
21.

"An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation."
Livnah O. , Johnson D.L. , Stura E.A. , Farrell F.X. , Barbone F.P. , You Y. , Liu K.D. , Goldsmith M.A. , He W. , Krause C.D. , Pestka S. , Jolliffe L.K. , Wilson I.A.
Nat. Struct. Biol.5:993-1004(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 34-244
22.

"Efficiency of signalling through cytokine receptors depends critically on receptor orientation."
Syed R.S. , Reid S.W. , Li C. , Cheetham J.C. , Aoki K.H. , Liu B. , Zhan H. , Osslund T.D. , Chirino A.J. , Zhang J. , Finer-Moore J. , Elliott S. , Sitney K. , Katz B.A. , Matthews D.J. , Wendoloski J.J. , Egrie J. , Stroud R.M.
Nature395:511-516(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 32-244 IN COMPLEX WITH EPO
23.

"Engineering a soluble extracellular erythropoietin receptor (EPObp) in Pichia pastoris to eliminate microheterogeneity, and its complex with erythropoietin."
Zhan H. , Liu B. , Reid S.W. , Aoki K.H. , Li C. , Syed R.S. , Karkaria C. , Koe G. , Sitney K. , Hayenga K. , Mistry F. , Savel L. , Dreyer M. , Katz B.A. , Schreurs J. , Matthews D.J. , Cheetham J.C. , Egrie J. , more...
Protein Eng.12:505-513(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 22-249 IN COMPLEX WITH EPO
24.

"Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation."
Livnah O. , Stura E.A. , Middleton S.A. , Johnson D.L. , Jolliffe L.K. , Wilson I.A.
Science283:987-990(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 34-246
25.

"Truncated erythropoietin receptor causes dominantly inherited benign human erythrocytosis."
de la Chapelle A. , Traskelin A.-L. , Juvonen E.
Proc. Natl. Acad. Sci. U.S.A.90:4495-4499(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN ECYT1
26.

"Mutation in the negative regulatory element of the erythropoietin receptor gene in a case of sporadic primary polycythemia."
Sokol L. , Prchal J.F. , D'Andrea A. , Rado T.A. , Prchal J.T.
Exp. Hematol.22:447-453(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ECYT1 SER-488
27.

"Missense mutation of the erythropoietin receptor is a rare event in human erythroid malignancies."
Le Couedic J.-P. , Mitjavila M.-T. , Villeval J.-L. , Feger F. , Gobert S. , Mayeux P. , Casadevall N. , Vainchenker W.
Blood87:1502-1511(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ECYT1 SER-487;VARIANT ERYTHROLEUKEMIA SER-487

Product Feedback Wall

* Email:
*Comments: