Epor ELISA Kit for Mouse(Mus musculus) | EIAab.comEpor ELISA Kit for Mouse(Mus musculus)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > Epor(Gene name) > Mouse

Epor (Gene name),

Erythropoietin receptor (Protein name ), EPOR_MOUSE from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

Epor;

Protein name:

Erythropoietin receptor(EPO-R);

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Forms homodimers on EPO stimulation. The tyrosine-phosphorylated form interacts with several SH2 domain-containing proteins including LYN, the adapter protein APS, PTPN6, PTPN11, JAK2, PI3 kinases, STAT5A/B, SOCS3 and CRKL. The N-terminal SH2 domain of PTPN6 binds Tyr-453 and inhibits signaling through dephosphorylation of JAK2. APS binding also inhibits the JAK-STAT signaling. Binding to PTPN11, preferentially through the N-terminal SH2 domain, promotes mitogenesis and phosphorylation of PTPN11. Binding of JAK2 (through its N-terminal) promotes cell-surface expression. Interaction with the ubiquitin ligase NOSIP mediates EPO-induced cell proliferation. Interacts with ATXN2L (By similarity). Forms heterooligomers with friend spleen focus-forming virus (FSFFV) gp55, probably via their respective transmembrane domains. Interacts with INPP5D/SHIP1.

Function:

Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.

Subcellular Location:

Isoform EPOR-S Secreted

Protein Attributes:

Sequence length:

507

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

507:

PGYVACS

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

KEGG:

mmu:13857

UniGene:

Mm.2653

SMR:

P14753

String:

P14753

Pfam:

PF09067

Uniprot:

P14753

FOR

ELISA Kit for Mouse EPO-R

Cat.:

E0027h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Mouse EPO-R

Cat.:

E0027r

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Mouse EPO-R

Cat.:

E0027p

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Mouse EPO-R

Cat.:

E0027m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Mouse EPO-R

Cat.:

E0027d

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse EPO-R

Cat.:

U0027r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse EPO-R

Cat.:

U0027m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse EPO-R

Cat.:

U0027d

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse EPO-R

Cat.:

U0027p

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Mouse EPO-R

Cat.:

U0027h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

Polyclonal Antibody for Mouse EPO-R

Cat.:

P0027Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse EPO-R

Cat.:

P0027Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse EPO-R

Cat.:

P0027Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse EPO-R

Protein for Mouse EPO-R

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Expression cloning of the murine erythropoietin receptor."
D'Andrea A.D. , Lodish H.F. , Wong G.G.
Cell57:277-285(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM EPOR-F)
tissue: Erythroleukemia.
2.

"Characterization of murine erythropoietin receptor genes."
Kuramochi S. , Ikawa Y. , Todokoro K.
J. Mol. Biol.216:567-575(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING (ISOFORMS EPOR-F AND EPOR-S)
strain: BALB/c.
tissue: Erythroleukemia.
tissue: Liver.
3.

"Unregulated expression of the erythropoietin receptor gene caused by insertion of spleen focus-forming virus long terminal repeat in a murine erythroleukemia cell line."
Hino M. , Tojo A. , Misawa Y. , Morii H. , Takaku F. , Shibuya M.
Mol. Cell. Biol.11:5527-5533(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM EPOR-F);ALTERNATIVE SPLICING DUE TO FRIEND SPLEEN FOCUS-FORMING VIRUS
tissue: Erythroleukemia.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM EPOR-F)
strain: C57BL/6J.
strain: FVB/N-3.
tissue: Mammary tumor.
5.

"Structure and transcription of the mouse erythropoietin receptor gene."
Youssoufian H. , Zon L.I. , Orkin S.H. , D'Andrea A.D. , Lodish H.F.
Mol. Cell. Biol.10:3675-3682(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27
6.

"Spleen focus-forming virus long terminal repeat insertional activation of the murine erythropoietin receptor gene in the T3Cl-2 friend leukemia cell line."
Lacombe C. , Chretien S. , Lemarchandel V. , Mayeux P. , Romeo P.-H. , Gisselbrecht S. , Cartron J.-P.
J. Biol. Chem.266:6952-6956(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-24
7.

"Inactivation of erythropoietin receptor function by point mutations in a region having homology with other cytokine receptors."
Miura O. , Cleveland J.L. , Ihle J.N.
Mol. Cell. Biol.13:1788-1795(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ERYTHROPOIETIN-INDUCED MITOGENESIS;MUTAGENESIS OF GLN-304; TRP-306; SER-317; GLU-324; LEU-330 AND GLU-331
8.

"Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo."
Miura O. , Nakamura N. , Quelle F.W. , Witthuhn B.A. , Ihle J.N. , Aoki N.
Blood84:1501-1507(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH JAK2;PHOSPHORYLATION;MUTAGENESIS OF TRP-306
9.

"Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals."
Klingmueller U. , Lorenz U. , Cantley L.C. , Neel B.G. , Lodish H.F.
Cell80:729-738(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTPN6;PHOSPHORYLATION AT TYR-453;MUTAGENESIS OF TYR-453; 453-TYR--TYR-455 AND TYR-455
10.

"Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis."
Tauchi T. , Damen J.E. , Toyama K. , Feng G.-S. , Broxmeyer H.E. , Krystal G.
Blood87:4495-4501(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTPN11;PHOSPHORYLATION AT TYR-425; TYR-455; TYR-484; TYR-488 AND TYR-503;MUTAGENESIS OF TYR-367; TYR-425; TYR-453; TYR-455; TYR-467; TYR-484; TYR-488 AND TYR-503
11.

"Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation."
Gobert S. , Chretien S. , Gouilleux F. , Muller O. , Pallard C. , Dusanter-Fourt I. , Groner B. , Lacombe C. , Gisselbrecht S. , Mayeux P.
EMBO J.15:2434-2441(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STAT5
12.

"Saturation mutagenesis of the WSXWS motif of the erythropoietin receptor."
Hilton D.J. , Watowich S.S. , Katz L. , Lodish H.F.
J. Biol. Chem.271:4699-4708(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF THE WSXWS MOTIF;MUTAGENESIS OF TRP-232; SER-233; ALA-234; TRP-235 AND SER-236
13.

"Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response."
Quelle F.W. , Wang D. , Nosaka T. , Thierfelder W.E. , Stravopodis D. , Weinstein Y. , Ihle J.N.
Mol. Cell. Biol.16:1622-1631(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STAT5;PHOSPHORYLATION AT TYR-367;MUTAGENESIS OF ARG-153; GLN-304; TRP-306; SER-317; GLU-324; LEU-330; GLU-331 AND TYR-367
14.

"Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway."
Chin H. , Arai A. , Wakao H. , Kamiyama R. , Miyasaka N. , Miura O.
Blood91:3734-3745(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WITH LYN
15.

"The SH2 inositol 5-phosphatase Ship1 is recruited in an SH2-dependent manner to the erythropoietin receptor."
Mason J.M. , Beattie B.K. , Liu Q. , Dumont D.J. , Barber D.L.
J. Biol. Chem.275:4398-4406(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INPP5D;PHOSPHORYLATION AT TYR-455
16.

"A common epitope is shared by activated signal transducer and activator of transcription-5 (STAT5) and the phosphorylated erythropoietin receptor: implications for the docking model of STAT activation."
Barber D.L. , Beattie B.K. , Mason J.M. , Nguyen M.H.-H. , Yoakim M. , Neel B.G. , D'Andrea A.D. , Frank D.A.
Blood97:2230-2237(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;STAT5 ACTIVATION
17.

"CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling."
Arai A. , Kanda E. , Nosaka Y. , Miyasaka N. , Miura O.
J. Biol. Chem.276:33282-33290(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CRKL AND LYN
18.

"The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit."
Wollberg P. , Lennartsson J. , Gottfridsson E. , Yoshimura A. , Ronnstrand L.
Biochem. J.370:1033-1038(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH APS
19.

"The WSAWS motif is C-hexosylated in a soluble form of the erythropoietin receptor."
Furmanek A. , Hess D. , Rogniaux H. , Hofsteenge J.
Biochemistry42:8452-8458(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF SER-233 AND ALA-234;GLYCOSYLATION AT TRP-232
20.

"The erythropoietin receptor transmembrane domain mediates complex formation with viral anemic and polycythemic gp55 proteins."
Constantinescu S.N. , Keren T. , Russ W.P. , Ubarretxena-Belandia I. , Malka Y. , Kubatzky K.F. , Engelman D.M. , Lodish H.F. , Henis Y.I.
J. Biol. Chem.278:43755-43763(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FRIEND SPLEEN FOCUS-FORMING VIRUS GP55
21.

"Ubiquitination regulates the internalization, endolysosomal sorting, and signaling of the erythropoietin receptor."
Bulut G.B. , Sulahian R. , Ma Y. , Chi N.W. , Huang L.J.
J. Biol. Chem.286:6449-6457(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION AT LYS-280 AND LYS-452

Product Feedback Wall

* Email:
*Comments: