Homodimer. Heterodimer with ERBB3. Heterodimer with each of the other ERBB receptors (Potential). Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with PRKCABP and PLXNB1. Interacts (when phosphorylated on Tyr-1248) with MEMO1. Interacts with MUC1; the interaction is enhanced by heregulin (HRG). Interacts (when phosphorylated on Tyr-1139) with GRB7 (via SH2 domain). Interacts (when phosphorylated on Tyr-1248) with ERBB2IP. Interacts with KPNB1, RANBP2, EEA1, CRM1, CLTC, RPA94 and ACTB.
Function:
In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);VARIANT ALA-1170
3.
NIEHS SNPs program
Submitted (2002-12) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS CYS-452; VAL-655 AND ALA-1170
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-191 (ISOFORM 1)
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-867 (ISOFORM 6)
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Cited for: NUCLEOTIDE SEQUENCE OF 1081-1245;VARIANT ALA-1170
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Cited for: INTERACTION WITH ERBB4;FUNCTION IN ACTIVATION OF STAT5A
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Cited for: IDENTIFICATION IN A COMPLEX WITH PIK3C2A AND EGFR;IDENTIFICATION IN A COMPLEX WITH PIK3C2B AND EGFR;INTERACTION WITH PIK3C2B
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Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
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Cited for: SUBCELLULAR LOCATION;NUCLEAR LOCALIZATION SIGNAL;INTERACTION WITH KPNB1; RANBP2; CRM1; EEA1 AND CLTC
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1248;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION;ALTERNATIVE INITIATION (ISOFORMS 2 AND 3);SUBCELLULAR LOCATION;MUTAGENESIS OF MET-611; MET-687; MET-706 AND MET-712
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Cited for: INTERACTION WITH ERBB4;AUTOPHOSPHORYLATION IN TRANS
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1054;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1054;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1107;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION IN NUCLEUS;INTERACTION WITH ACTB AND RPA194;SUBCELLULAR LOCATION
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1054;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 654-662 IN COMPLEX WITH HLA AND BETA-2 MICROGLOBULIN
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Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS) OF 1247-1255 IN COMPLEX WITH ERBB2IP;INTERACTION WITH ERBB2IP
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Cited for: STRUCTURE BY NMR OF 1135-1144 IN COMPLEX WITH GRB7;INTERACTION WITH GRB7
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Cited for: X-RAY CRYSTALLOGRAPHY (2.52 ANGSTROMS) OF 23-629 IN COMPLEX WITH THE ANTIBODY HERCEPTIN
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Cited for: X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS) OF 23-646 IN COMPLEX WITH THE ANTIBODY PERTUZUMAB;INTERACTION WITH ERBB3;MUTAGENESIS OF 317-LEU-HIS-318;DISULFIDE BONDS;GLYCOSYLATION AT ASN-187; ASN-259 AND ASN-530
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Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 23-646 IN COMPLEX WITH THE ANTIBODY HERCEPTIN;DISULFIDE BONDS;GLYCOSYLATION AT ASN-259 AND ASN-530
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Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 23-646 IN COMPLEX WITH ENGINEERED ANTIBODY ZHER2;DISULFIDE BONDS;GLYCOSYLATION AT ASN-68; ASN-259 AND ASN-571
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Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 703-1029 IN COMPLEX WITH INHIBITOR SYR127063;CATALYTIC ACTIVITY;SUBUNIT;ENZYME REGULATION
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Cited for: VARIANTS PRO-755; SER-776; ALA-TYR-VAL-MET-774 INS AND VAL-GLY-SER-779 INS; SER-857 AND LYS-914;INVOLVEMENT IN CANCER
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Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-654; VAL-655; SER-768; SER-776; SER-857; ALA-1170 AND ASP-1216