Protein name:
Fibulin-1 (FIBL-1) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homomultimerizes and interacts with various extracellular matrix components such as FN1, LAMA1, LAMA2, NID, ACAN, CSPG2 and type IV collagen. Interacts also with APP, NOV, FGB and HPV type 16, HPV type 18, HPV type 31 and BPV type 1 E6 proteins. Interacts with FBLN7.
Function:
Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP.
Subcellular Location:
Secreted
extracellular space
extracellular matrix
Protein Attributes:
50:
MERAAPSRRV | PLPLLLLGGL | ALLAAGVDAD | VLLEACCADG | HRMATHQKDC |
100:
SLPYATESKE | CRMVQEQCCH | SQLEELHCAT | GISLANEQDR | CATPHGDNAS |
150:
LEATFVKRCC | HCCLLGRAAQ | AQGQSCEYSL | MVGYQCGQVF | QACCVKSQET |
200:
GDLDVGGLQE | TDKIIEVEEE | QEDPYLNDRC | RGGGPCKQQC | RDTGDEVVCS |
250:
CFVGYQLLSD | GVSCEDVNEC | ITGSHSCRLG | ESCINTVGSF | RCQRDSSCGT |
300:
GYELTEDNSC | KDIDECESGI | HNCLPDFICQ | NTLGSFRCRP | KLQCKSGFIQ |
350:
DALGNCIDIN | ECLSISAPCP | IGHTCINTEG | SYTCQKNVPN | CGRGYHLNEE |
400:
GTRCVDVDEC | APPAEPCGKG | HRCVNSPGSF | RCECKTGYYF | DGISRMCVDV |
450:
NECQRYPGRL | CGHKCENTLG | SYLCSCSVGF | RLSVDGRSCE | DINECSSSPC |
500:
SQECANVYGS | YQCYCRRGYQ | LSDVDGVTCE | DIDECALPTG | GHICSYRCIN |
550:
IPGSFQCSCP | SSGYRLAPNG | RNCQDIDECV | TGIHNCSINE | TCFNIQGGFR |
600:
CLAFECPENY | RRSAATLQQE | KTDTVRCIKS | CRPNDVTCVF | DPVHTISHTV |
650:
ISLPTFREFT | RPEEIIFLRA | ITPPHPASQA | NIIFDITEGN | LRDSFDIIKR |
700:
YMDGMTVGVV | RQVRPIVGPF | HAVLKLEMNY | VVGGVVSHRN | VVNVHIFVSE |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Chicken
ELISA Kit for Human FIBL-1
ELISA Kit for Human FIBL-1
ELISA Kit for Human FIBL-1
CLIA Kit for Human FIBL-1
CLIA Kit for Human FIBL-1
CLIA Kit for Human FIBL-1
Polyclonal Antibody for Human FIBL-1
Polyclonal Antibody for Human FIBL-1
Polyclonal Antibody for Human FIBL-1
Monoclonal Antibody for Human FIBL-1
Monoclonal Antibody for Human FIBL-1
Monoclonal Antibody for Human FIBL-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
K Bergmann, A Mańkowska-Cyl, Marek Kretowicz, et al.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND C);VARIANT ARG-141
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM D);TISSUE SPECIFICITY;VARIANT ARG-141;INTERACTION WITH FN1 AND FGB
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM D);VARIANTS ARG-141 AND ARG-695
4.
"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Wan D.
,
Gong Y.
,
Qin W.
,
Zhang P.
,
Li J.
,
Wei L.
,
Zhou X.
,
Li H.
,
Qiu X.
,
Zhong F.
,
He L.
,
Yu J.
,
Yao G.
,
Jiang H.
,
Qian L.
,
Yu Y.
,
Shu H.
,
Chen X.
,
Xu H.
,
Guo M.
,
Pan Z.
,
Chen Y.
,
Ge C.
,
Yang S.
,
Gu J.
more...
Proc. Natl. Acad. Sci. U.S.A.101:15724-15729(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C);VARIANT ARG-141
5.
"The DNA sequence of human chromosome 22."
Dunham I.
,
Hunt A.R.
,
Collins J.E.
,
Bruskiewich R.
,
Beare D.M.
,
Clamp M.
,
Smink L.J.
,
Ainscough R.
,
Almeida J.P.
,
Babbage A.K.
,
Bagguley C.
,
Bailey J.
,
Barlow K.F.
,
Bates K.N.
,
Beasley O.P.
,
Bird C.P.
,
Blakey S.E.
,
Bridgeman A.M.
,
Buck D.
,
Burgess J.
,
Burrill W.D.
,
Burton J.
,
Carder C.
,
Carter N.P.
,
Chen Y.
,
Clark G.
,
Clegg S.M.
,
Cobley V.E.
,
Cole C.G.
,
Collier R.E.
,
Connor R.
,
Conroy D.
,
Corby N.R.
,
Coville G.J.
,
Cox A.V.
,
Davis J.
,
Dawson E.
,
Dhami P.D.
,
Dockree C.
,
Dodsworth S.J.
,
Durbin R.M.
,
Ellington A.G.
,
Evans K.L.
,
Fey J.M.
,
Fleming K.
,
French L.
,
Garner A.A.
,
Gilbert J.G.R.
,
Goward M.E.
,
Grafham D.V.
,
Griffiths M.N.D.
,
Hall C.
,
Hall R.E.
,
Hall-Tamlyn G.
,
Heathcott R.W.
,
Ho S.
,
Holmes S.
,
Hunt S.E.
,
Jones M.C.
,
Kershaw J.
,
Kimberley A.M.
,
King A.
,
Laird G.K.
,
Langford C.F.
,
Leversha M.A.
,
Lloyd C.
,
Lloyd D.M.
,
Martyn I.D.
,
Mashreghi-Mohammadi M.
,
Matthews L.H.
,
Mccann O.T.
,
Mcclay J.
,
Mclaren S.
,
McMurray A.A.
,
Milne S.A.
,
Mortimore B.J.
,
Odell C.N.
,
Pavitt R.
,
Pearce A.V.
,
Pearson D.
,
Phillimore B.J.C.T.
,
Phillips S.H.
,
Plumb R.W.
,
Ramsay H.
,
Ramsey Y.
,
Rogers L.
,
Ross M.T.
,
Scott C.E.
,
Sehra H.K.
,
Skuce C.D.
,
Smalley S.
,
Smith M.L.
,
Soderlund C.
,
Spragon L.
,
Steward C.A.
,
Sulston J.E.
,
Swann R.M.
,
Vaudin M.
,
Wall M.
,
Wallis J.M.
,
Whiteley M.N.
,
Willey D.L.
,
Williams L.
,
Williams S.A.
,
Williamson H.
,
Wilmer T.E.
,
Wilming L.
,
Wright C.L.
,
Hubbard T.
,
Bentley D.R.
,
Beck S.
,
Rogers J.
,
Shimizu N.
,
Minoshima S.
,
Kawasaki K.
,
Sasaki T.
,
Asakawa S.
,
Kudoh J.
,
Shintani A.
,
Shibuya K.
,
Yoshizaki Y.
,
Aoki N.
,
Mitsuyama S.
,
Roe B.A.
,
Chen F.
,
Chu L.
,
Crabtree J.
,
Deschamps S.
,
Do A.
,
Do T.
,
Dorman A.
,
Fang F.
,
Fu Y.
,
Hu P.
,
Hua A.
,
Kenton S.
,
Lai H.
,
Lao H.I.
,
Lewis J.
,
Lewis S.
,
Lin S.-P.
,
Loh P.
,
Malaj E.
,
Nguyen T.
,
Pan H.
,
Phan S.
,
Qi S.
,
Qian Y.
,
Ray L.
,
Ren Q.
,
Shaull S.
,
Sloan D.
,
Song L.
,
Wang Q.
,
Wang Y.
,
Wang Z.
,
White J.
,
Willingham D.
,
Wu H.
,
Yao Z.
,
Zhan M.
,
Zhang G.
,
Chissoe S.
,
Murray J.
,
Miller N.
,
Minx P.
,
Fulton R.
,
Johnson D.
,
Bemis G.
,
Bentley D.
,
Bradshaw H.
,
Bourne S.
,
Cordes M.
,
Du Z.
,
Fulton L.
,
Goela D.
,
Graves T.
,
Hawkins J.
,
Hinds K.
,
Kemp K.
,
Latreille P.
,
Layman D.
,
Ozersky P.
,
Rohlfing T.
,
Scheet P.
,
Walker C.
,
Wamsley A.
,
Wohldmann P.
,
Pepin K.
,
Nelson J.
,
Korf I.
,
Bedell J.A.
,
Hillier L.W.
,
Mardis E.
,
Waterston R.
,
Wilson R.
,
Emanuel B.S.
,
Shaikh T.
,
Kurahashi H.
,
Saitta S.
,
Budarf M.L.
,
McDermid H.E.
,
Johnson A.
,
Wong A.C.C.
,
Morrow B.E.
,
Edelmann L.
,
Kim U.J.
,
Shizuya H.
,
Simon M.I.
,
Dumanski J.P.
,
Peyrard M.
,
Kedra D.
,
Seroussi E.
,
Fransson I.
,
Tapia I.
,
Bruder C.E.
,
O'Brien K.P.
,
Wilkinson P.
,
Bodenteich A.
,
Hartman K.
,
Hu X.
,
Khan A.S.
,
Lane L.
,
Tilahun Y.
,
Wright H.
more...
Nature402:489-495(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C);VARIANT ARG-141
tissue :
Brain .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-26
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 30-44
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SELF-ASSOCIATION;INTERACTION WITH FN1
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : POSSIBLE FUNCTION
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FGB
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DEVELOPMENTAL STAGE
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CALCIUM-BINDING;SELF-ASSOCIATION;FN1-BINDING SITES
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ROLE IN TUMOR FORMATION AND INVASION
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ROLE IN TUMOR FORMATION AND INVASION
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH NOV
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ROLE IN CELL ADHESION AND MOTILITY
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH APP
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HIGH-RISK HUMAN PAPILLOMAVIRUSES E6 PROTEIN;INHIBITION OF E6-MEDIATED TRANSFORMATION
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHROMOSOMAL TRANSLOCATION
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ASSOCIATION WITH BREAST CANCER
25.
"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Jia W.
,
Lu Z.
,
Fu Y.
,
Wang H.P.
,
Wang L.H.
,
Chi H.
,
Yuan Z.F.
,
Zheng Z.B.
,
Song L.N.
,
Han H.H.
,
Liang Y.M.
,
Wang J.L.
,
Cai Y.
,
Zhang Y.K.
,
Deng Y.L.
,
Ying W.T.
,
He S.M.
,
Qian X.H.
Mol. Cell. Proteomics8:913-923(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION AT ASN-98