FGF23 ELISA Kit for Human(Homo sapiens) | EIAab.comFGF23 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > FGF23(Gene name) > Human

FGF23 (Gene name),

Fibroblast growth factor 23 (Protein name ), FGF23_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (2)

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Gene name:

FGF23(UNQ3027/PRO9828;HYPF);

Protein name:

Fibroblast growth factor 23(FGF-23);

Alternative:

Tumor-derived hypophosphatemia-inducing factor;Phosphatonin;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL and heparan sulfate glycosaminoglycans that function as coreceptors.

Function:

Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization.

Subcellular Location:

Secreted Secretion is dependent on O-glycosylation.

Protein Attributes:

Sequence length:

251

Sequence:

50:

100:

150:

200:

250:

251:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q9GZV9

STRING:

9606.ENSP00000237837

SMR:

Q9GZV9

MIM:

193100

UniGene:

Hs.287370

KEGG:

hsa:8074

Pfam:

PF00167

Uniprot:

Q9GZV9

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ELISA Kit for Human FGF-23

Cat.:

E0746m

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96T

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ELISA Kit for Human FGF-23

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E0746h

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96T

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ELISA Kit for Human FGF-23

Cat.:

E0746r

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CLIA Kit for Human FGF-23

Cat.:

U0746h

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96T

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CLIA Kit for Human FGF-23

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U0746m

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96T

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CLIA Kit for Human FGF-23

Cat.:

U0746r

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96T

Polyclonal Antibody for Human FGF-23

Cat.:

P0746Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human FGF-23

Cat.:

P0746Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human FGF-23

Cat.:

P0746Rb-r

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40ug/0.2ml

Monoclonal Antibody for Human FGF-23

Protein for Human FGF-23

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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Citations

[1].

"Study Of Fibroblast Growth Factor 23 (Fgf23) And Anemia In Hemodialysis Patients And Ckd Patients Stages 3 & 4"

A ali Ibrahim, A talaat El-ganzoury.

From:Life Science Journal

[2].

"Impact of Fibroblast Growth Factor-23 on Peripheral Arterial Disease in Type 2 Diabetes Mellitus: A Comparative Cross-Sectional Pilot Study"

E Hatipoğlu, N Özgür, M Niyazoğlu, et al.

From:Turkish Journal of Endocrinology and Metabolism

References

1.

"Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain."
Yamashita T. , Yoshioka M. , Itoh N.
Biochem. Biophys. Res. Commun.277:494-498(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23."
White K.E. , Evans W.E. , O'Riordan J.L.H. , Speer M.C. , Econs M.J. , Lorenz-Depiereux B. , Grabowski M. , Meitinger T. , Strom T.M.
Nat. Genet.26:345-348(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;VARIANTS ADHR GLN-176; GLN-179 AND TRP-179;VARIANT MET-239
3.

"Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia."
Shimada T. , Mizutani S. , Muto T. , Yoneya T. , Hino R. , Takeda S. , Takeuchi Y. , Fujita T. , Fukumoto S. , Yamashita T.
Proc. Natl. Acad. Sci. U.S.A.98:6500-6505(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.

NIEHS SNPs program
Submitted (2004-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS SER-195 AND MET-239
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
7.

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z. , Henzel W.J.
Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 25-39
8.

"FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate."
Bowe A.E. , Finnegan R. , Jan de Beur S.M. , Cho J. , Levine M.A. , Kumar R. , Schiavi S.C.
Biochem. Biophys. Res. Commun.284:977-981(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CHARACTERIZATION OF VARIANT ADHR GLN-179
9.

"The autosomal dominant hypophosphatemic rickets (ADHR) gene is a secreted polypeptide overexpressed by tumors that cause phosphate wasting."
White K.E. , Jonsson K.B. , Carn G. , Hampson G. , Spector T.D. , Mannstadt M. , Lorenz-Depiereux B. , Miyauchi A. , Yang I.M. , Ljunggren O. , Meitinger T. , Strom T.M. , Jueppner H. , Econs M.J.
J. Clin. Endocrinol. Metab.86:497-500(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING
10.

"Mutant FGF-23 responsible for autosomal dominant hypophosphatemic rickets is resistant to proteolytic cleavage and causes hypophosphatemia in vivo."
Shimada T. , Muto T. , Urakawa I. , Yoneya T. , Yamazaki Y. , Okawa K. , Takeuchi Y. , Fujita T. , Fukumoto S. , Yamashita T.
Endocrinology143:3179-3182(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING
11.

"FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting."
Riminucci M. , Collins M.T. , Fedarko N.S. , Cherman N. , Corsi A. , White K.E. , Waguespack S. , Gupta A. , Hannon T. , Econs M.J. , Bianco P. , Gehron Robey P.
J. Clin. Invest.112:683-692(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
12.

"FGF23 is processed by proprotein convertases but not by PHEX."
Benet-Pages A. , Lorenz-Depiereux B. , Zischka H. , White K.E. , Econs M.J. , Strom T.M.
Bone35:455-462(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING BY PROPROTEIN CONVERTASES
13.

"FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis."
Shimada T. , Hasegawa H. , Yamazaki Y. , Muto T. , Hino R. , Takeuchi Y. , Fujita T. , Nakahara K. , Fukumoto S. , Yamashita T.
J. Bone Miner. Res.19:429-435(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
Zhang X. , Ibrahimi O.A. , Olsen S.K. , Umemori H. , Mohammadi M. , Ornitz D.M.
J. Biol. Chem.281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FGFR1; FGFR2; FGFR3 AND FGFR4;FUNCTION IN STIMULATION OF CELL PROLIFERATION
15.

"Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation."
Kato K. , Jeanneau C. , Tarp M.A. , Benet-Pages A. , Lorenz-Depiereux B. , Bennett E.P. , Mandel U. , Strom T.M. , Clausen H.
J. Biol. Chem.281:18370-18377(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;GLYCOSYLATION AT THR-178;CHARACTERIZATION OF VARIANTS ADHR GLN-176 AND GLN-179;IDENTIFICATION BY MASS SPECTROMETRY
16.

"Overexpression of fibroblast growth factor 23 suppresses osteoblast differentiation and matrix mineralization in vitro."
Wang H. , Yoshiko Y. , Yamamoto R. , Minamizaki T. , Kozai K. , Tanne K. , Aubin J.E. , Maeda N.
J. Bone Miner. Res.23:939-948(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
17.

"Fibroblast growth factor signalling: from development to cancer."
Turner N. , Grose R.
Nat. Rev. Cancer10:116-129(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
18.

"Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members."
Goetz R. , Beenken A. , Ibrahimi O.A. , Kalinina J. , Olsen S.K. , Eliseenkova A.V. , Xu C. , Neubert T.A. , Zhang F. , Linhardt R.J. , Yu X. , White K.E. , Inagaki T. , Kliewer S.A. , Yamamoto M. , Kurosu H. , Ogawa Y. , Kuro-o M. , more...
Mol. Cell. Biol.27:3417-3428(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 25-179
19.

"A novel homozygous missense mutation in FGF23 causes Familial Tumoral Calcinosis associated with disseminated visceral calcification."
Chefetz I. , Heller R. , Galli-Tsinopoulou A. , Richard G. , Wollnik B. , Indelman M. , Koerber F. , Topaz O. , Bergman R. , Sprecher E. , Schoenau E.
Hum. Genet.118:261-266(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HFTC THR-96
20.

"An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia."
Benet-Pages A. , Orlik P. , Strom T.M. , Lorenz-Depiereux B.
Hum. Mol. Genet.14:385-390(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HFTC GLY-71
21.

"A novel mutation in fibroblast growth factor 23 gene as a cause of tumoral calcinosis."
Araya K. , Fukumoto S. , Backenroth R. , Takeuchi Y. , Nakayama K. , Ito N. , Yoshii N. , Yamazaki Y. , Yamashita T. , Silver J. , Igarashi T. , Fujita T.
J. Clin. Endocrinol. Metab.90:5523-5527(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HFTC PHE-129;CHARACTERIZATION OF VARIANT HFTC PHE-129
22.

"A new missense mutation in FGF23 gene in a male with hyperostosis-hyperphosphatemia syndrome (HHS)."
Abbasi F. , Ghafouri-Fard S. , Javaheri M. , Dideban A. , Ebrahimi A. , Ebrahim-Habibi A.
Gene542:269-271(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HFTC LEU-157

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